RRM1

Last updated • 1 min readFrom Wikipedia, The Free Encyclopedia
RRM1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RRM1 , R1, RIR1, RR1, ribonucleotide reductase catalytic subunit M1
External IDs OMIM: 180410 MGI: 98180 HomoloGene: 806 GeneCards: RRM1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001033
NM_001318064
NM_001318065
NM_001330193

NM_009103

RefSeq (protein)

NP_001024
NP_001304993
NP_001304994
NP_001317122

NP_033129

Location (UCSC) Chr 11: 4.09 – 4.14 Mb Chr 7: 102.09 – 102.12 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ribonucleoside-diphosphate reductase large subunit is an enzyme that in humans is encoded by the RRM1 gene. [5] [6]

Contents

This gene encodes one of two non-identical subunits which constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. This gene is oriented in a head-to-tail configuration with the stromal interaction molecule 1 gene (STIM1), with the 3' end of STIM1 situated 1.6 kb from the 5' end of this gene. [6]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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FluoropyrimidineActivity WP1601.png go to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to WikiPathwaysgo to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to article
|alt=Fluorouracil (5-FU) Activity edit]]
Fluorouracil (5-FU) Activity edit
  1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

See also

Related Research Articles

<span class="mw-page-title-main">Ribonucleotide reductase</span> Class of enzymes

Ribonucleotide reductase (RNR), also known as ribonucleoside diphosphate reductase (rNDP), is an enzyme that catalyzes the formation of deoxyribonucleotides from ribonucleotides. It catalyzes this formation by removing the 2'-hydroxyl group of the ribose ring of nucleoside diphosphates. This reduction produces deoxyribonucleotides. Deoxyribonucleotides in turn are used in the synthesis of DNA. The reaction catalyzed by RNR is strictly conserved in all living organisms. Furthermore, RNR plays a critical role in regulating the total rate of DNA synthesis so that DNA to cell mass is maintained at a constant ratio during cell division and DNA repair. A somewhat unusual feature of the RNR enzyme is that it catalyzes a reaction that proceeds via a free radical mechanism of action. The substrates for RNR are ADP, GDP, CDP and UDP. dTDP is synthesized by another enzyme from dTMP.

<span class="mw-page-title-main">PTP4A2</span> Protein-coding gene in the species Homo sapiens

Protein tyrosine phosphatase type IVA 2 is an enzyme that in humans is encoded by the PTP4A2 gene.

<span class="mw-page-title-main">RRM2B</span> Protein-coding gene in the species Homo sapiens

Ribonucleotide-diphosphate reductase subunit M2 B is an enzyme that in humans is encoded by the RRM2B gene. The gene encoding the RRM2B protein is located on chromosome 8, at position 8q23.1. The gene and its products are also known by designations MTDPS8A, MTDPS8B, and p53R2.

<span class="mw-page-title-main">POLD2</span> Protein-coding gene in the species Homo sapiens

DNA polymerase delta subunit 2 is an enzyme that in humans is encoded by the POLD2 gene. It is a component of the DNA polymerase delta complex.

<span class="mw-page-title-main">UQCRC1</span> Protein-coding gene in the species Homo sapiens

Cytochrome b-c1 complex subunit 1, mitochondrial is a protein that in humans is encoded by the UQCRC1 gene.

<span class="mw-page-title-main">60S ribosomal protein L21</span> Protein-coding gene in the species Homo sapiens

60S ribosomal protein L21 is a protein that in humans is encoded by the RPL21 gene.

<span class="mw-page-title-main">60S ribosomal protein L35a</span> Protein-coding gene in the species Homo sapiens

60S ribosomal protein L35a is a protein that in humans is encoded by the RPL35A gene.

<span class="mw-page-title-main">60S ribosomal protein L35</span> Protein-coding gene in the species Homo sapiens

60S ribosomal protein L35 is a protein that in humans is encoded by the RPL35 gene.

<span class="mw-page-title-main">PPP1R11</span> Protein-coding gene in the species Homo sapiens

Protein phosphatase 1 regulatory subunit 11 is an enzyme that in humans is encoded by the PPP1R11 gene.

<span class="mw-page-title-main">PRIM2</span> Protein-coding gene in the species Homo sapiens

DNA primase large subunit is an enzyme that in humans is encoded by the PRIM2 gene.

<span class="mw-page-title-main">40S ribosomal protein S8</span> Protein-coding gene in the species Homo sapiens

40S ribosomal protein S8 is a protein that in humans is encoded by the RPS8 gene.

<span class="mw-page-title-main">DNAH9</span> Protein-coding gene in the species Homo sapiens

Dynein heavy chain 9, axonemal is a protein that in humans is encoded by the DNAH9 gene.

<span class="mw-page-title-main">MRPS7</span> Protein-coding gene in the species Homo sapiens

28S ribosomal protein S7, mitochondrial is a protein that in humans is encoded by the MRPS7 gene.

<span class="mw-page-title-main">Mitochondrial ribosomal protein L20</span> Protein-coding gene in the species Homo sapiens

39S ribosomal protein L20, mitochondrial is a protein that in humans is encoded by the MRPL20 gene.

<span class="mw-page-title-main">MRPS24</span> Protein-coding gene in the species Homo sapiens

28S ribosomal protein S24, mitochondrial is a protein that in humans is encoded by the MRPS24 gene.

<span class="mw-page-title-main">Mitochondrial ribosomal protein L32</span> Protein-coding gene in the species Homo sapiens

39S ribosomal protein L32, mitochondrial is a protein that in humans is encoded by the MRPL32 gene.

<span class="mw-page-title-main">UQCRH</span> Protein-coding gene in the species Homo sapiens

Cytochrome b-c1 complex subunit 6, mitochondrial is a protein that in humans is encoded by the UQCRH gene.

<span class="mw-page-title-main">CCNF</span> Protein-coding gene in humans

G2/mitotic-specific cyclin-F is a protein that in humans is encoded by the CCNF gene.

<span class="mw-page-title-main">RRM2</span> Protein-coding gene in the species Homo sapiens

Ribonucleoside-diphosphate reductase subunit M2, also known as ribonucleotide reductase small subunit, is an enzyme that in humans is encoded by the RRM2 gene.

<span class="mw-page-title-main">RNASEH2C</span> Protein-coding gene in the species Homo sapiens

Ribonuclease H2 subunit C is a protein that in humans is encoded by the RNASEH2C gene. RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits, and degrades the RNA of RNA:DNA hybrids.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000167325 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030978 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Parker NJ, Begley CG, Fox RM (Nov 1995). "Human gene for the large subunit of ribonucleotide reductase (RRM1): functional analysis of the promoter". Genomics. 27 (2): 280–5. doi:10.1006/geno.1995.1043. PMID   7557993.
  6. 1 2 "Entrez Gene: RRM1 ribonucleotide reductase M1 polypeptide".

Further reading