Dichlorochromopyrrolate synthase

Dichlorochromopyrrolate synthase
Identifiers
EC no.	1.21.3.9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Dichlorochromopyrrolate synthase (EC 1.21.3.9, RebD, dichlorochromopyrrolic acid synthase) is an enzyme with systematic name 2-imino-3-(7-chloroindol-3-yl)propanoate ammonia-lyase (dichlorochromopyrrolate-forming). ^{[1] [2]} This enzyme catalyses the following chemical reaction

4 2-imino-3-(7-chloroindol-3-yl)propanoate + O₂${\displaystyle \rightleftharpoons }$ 2 dichlorochromopyrrolate + 2 NH₃ + 2 H₂O

This enzyme catalyses a step in the biosynthesis of rebeccamycin.

References

1. Nishizawa T, Grüschow S, Jayamaha DH, Nishizawa-Harada C, Sherman DH (January 2006). "Enzymatic assembly of the bis-indole core of rebeccamycin". Journal of the American Chemical Society. 128 (3): 724–5. Bibcode:2006JAChS.128..724N. doi:10.1021/ja056749x. PMID   16417354.
2. Howard-Jones AR, Walsh CT (December 2005). "Enzymatic generation of the chromopyrrolic acid scaffold of rebeccamycin by the tandem action of RebO and RebD". Biochemistry. 44 (48): 15652–63. CiteSeerX   10.1.1.537.5773 . doi:10.1021/bi051706e. PMID   16313168.

External links

• Chromopyrrolate+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)