GLRX3

GLRX3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DIY, 2WZ9, 2YAN, 3ZYW
Identifiers
Aliases	GLRX3 , GLRX4, GRX3, GRX4, PICOT, TXNL2, TXNL3, glutaredoxin 3
External IDs	OMIM: 612754 MGI: 1353653 HomoloGene: 4769 GeneCards: GLRX3
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q26.3 Start 130,136,391 bp [1] End 130,184,521 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 F4 Start 137,039,343 bp [2] End 137,070,323 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans right adrenal gland left adrenal gland body of pancreas left ventricle rectum right ventricle ganglionic eminence smooth muscle tissue skin of abdomen Top expressed in spermatid spermatocyte yolk sac ankle joint corneal stroma plantaris muscle entorhinal cortex extensor digitorum longus muscle morula superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-disulfide reductase activity electron transfer activity iron-sulfur cluster binding protein binding metal ion binding protein kinase C binding RNA binding identical protein binding glutathione disulfide oxidoreductase activity Cellular component cytoplasm dendrite cell cortex Z disc extracellular exosome nucleus cytosol Biological process cell redox homeostasis negative regulation of cardiac muscle hypertrophy regulation of the force of heart contraction [2Fe-2S cluster assembly] protein maturation by iron-sulfur cluster transfer electron transport chain cellular iron ion homeostasis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10539 30926 Ensembl ENSG00000108010 ENSMUSG00000031068 UniProt O76003 Q9CQM9 RefSeq (mRNA) NM_001199868 NM_006541 NM_001321980 NM_023140 NM_001348093 RefSeq (protein) NP_001186797 NP_001308909 NP_006532 NP_075629 NP_001335022 Location (UCSC) Chr 10: 130.14 – 130.18 Mb Chr 7: 137.04 – 137.07 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Glutaredoxin-3 is a protein that in humans is encoded by the GLRX3 gene. ^{[5] [6] [7]}

Interactions

GLRX3 has been shown to interact with PRKCQ. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000108010 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031068 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Witte S, Villalba M, Bi K, Liu Y, Isakov N, Altman A (Feb 2000). "Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain". J Biol Chem. 275 (3): 1902–9. doi: 10.1074/jbc.275.3.1902 . PMID   10636891.
6. Stanchi F, Bertocco E, Toppo S, Dioguardi R, Simionati B, Cannata N, Zimbello R, Lanfranchi G, Valle G (Jan 2001). "Characterization of 16 novel human genes showing high similarity to yeast sequences". Yeast. 18 (1): 69–80. doi: 10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H . PMID   11124703. S2CID   21397515.
7. "Entrez Gene: TXNL2 thioredoxin-like 2".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.

External links

• Overview of all the structural information available in the PDB for UniProt : O76003 (Human Glutaredoxin-3 (GLRX3)) at the PDBe-KB .