HS2ST1

HS2ST1
Identifiers
Aliases	HS2ST1 , dJ604K5.2, heparan sulfate 2-O-sulfotransferase 1, NFSRA
External IDs	OMIM: 604844 MGI: 1346049 HomoloGene: 8025 GeneCards: HS2ST1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	87,109,982 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	144,275,942 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; endothelial cell; ; left adrenal gland; ; stromal cell of endometrium; ; retinal pigment epithelium; ; parietal pleura; ; islet of Langerhans; ; Brodmann area 23; ; embryo; ; Achilles tendon;
	Top expressed in
	right lung; ; left lung; ; right lung lobe; ; left lung lobe; ; medial ganglionic eminence; ; ciliary body; ; secondary oocyte; ; iris; ; condyle; ; pineal gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity ; sulfotransferase activity ; heparan sulfate 2-O-sulfotransferase activity ;
Cellular component	integral component of membrane ; Golgi membrane ; Golgi apparatus ; membrane ;
Biological process	glycosaminoglycan biosynthetic process ; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process ; heparan sulfate proteoglycan biosynthetic process, enzymatic modification ;
	Sources:Amigo / QuickGO
Orthologs
	9653
	23908
	ENSG00000153936
	ENSMUSG00000040151
	Q7LGA3
	Q8R3H7
	NM_012262 ; NM_001134492
	NM_011828 ; NM_001355234
	NP_001127964 ; NP_036394
	NP_035958 ; NP_001342163
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 21, 2023

Heparan sulfate 2-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS2ST1 gene.^[5]^[6]

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes heparan sulfate 2-O-sulfotransferase, a member of the heparan sulfate biosynthetic enzyme family. This family member transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate.

The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation.^[6]

Related Research Articles

Heparan sulfate (HS) is a linear polysaccharide found in all animal tissues. It occurs as a proteoglycan in which two or three HS chains are attached in close proximity to cell surface or extracellular matrix proteins. In this form, HS binds to a variety of protein ligands, including Wnt, and regulates a wide range of biological activities, including developmental processes, angiogenesis, blood coagulation, abolishing detachment activity by GrB, and tumour metastasis. HS has also been shown to serve as cellular receptor for a number of viruses, including the respiratory syncytial virus. One study suggests that cellular heparan sulfate has a role in SARS-CoV-2 Infection, particularly when the virus attaches with ACE2.

Estrogen sulfotransferase is an enzyme that in humans is encoded by the SULT1E1 gene.

Carbohydrate sulfotransferase 6 is an enzyme that in humans is encoded by the CHST6 gene.

Carbohydrate sulfotransferase 2 is an enzyme that in humans is encoded by the CHST2 gene.

Carbohydrate sulfotransferase 4 is an enzyme that in humans is encoded by the CHST4 gene.

Galactosylceramide sulfotransferase is an enzyme that in humans is encoded by the GAL3ST1 gene.

Carbohydrate sulfotransferase 1 is an enzyme that in humans is encoded by the CHST1 gene.

Sulfotransferase family cytosolic 1B member 1 is an enzyme that in humans is encoded by the SULT1B1 gene.

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 is an enzyme. In humans, it is encoded by the NDST1 gene.

Carbohydrate sulfotransferase 15 is an enzyme that in humans is encoded by the CHST15 gene. It belongs to the N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase enzyme class.

Galactose-3-O-sulfotransferase 2 is an enzyme that in humans is encoded by the GAL3ST2 gene.

Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 is an enzyme that in humans is encoded by the HS3ST3A1 gene.

Heparan sulfate glucosamine 3-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS3ST1 gene.

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 is an enzyme that in humans is encoded by the NDST2 gene.

Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 is an enzyme that in humans is encoded by the HS3ST3B1 gene. Heparan sulfate biosynthetic enzymes are key components in generating myriad distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity ( HS3ST3A1). The Sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1 and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta.

D-glucuronyl C5-epimerase is an enzyme that in humans is encoded by the GLCE gene.

Carbohydrate sulfotransferase 7 is an enzyme that in humans is encoded by the CHST7 gene.

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 is an enzyme that in humans is encoded by the NDST3 gene. It catalyses the reaction:

3'-phosphoadenylyl sulfate + α-D-glucosaminyl-[heparan sulfate]_(n) = adenosine 3',5'-bisphosphate + 2 H⁺ + N-sulfo-α-D-glucosaminyl-[heparan sulfate]_(n)

Heparan sulfate glucosamine 3-O-sulfotransferase 2 is an enzyme that in humans is encoded by the HS3ST2 gene.

Bile salt sulfotransferase also known as hydroxysteroid sulfotransferase (HST) or sulfotransferase 2A1 (ST2A1) is an enzyme that in humans is encoded by the SULT2A1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000153936 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040151 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (Feb 1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi: 10.1093/dnares/4.5.345 . PMID 9455484.
1 2 "Entrez Gene: HS2ST1 heparan sulfate 2-O-sulfotransferase 1".

Muramatsu T (2000). "Essential roles of carbohydrate signals in development, immune response and tissue functions, as revealed by gene targeting". J. Biochem. 127 (2): 171–6. doi: 10.1093/oxfordjournals.jbchem.a022590 . PMID 10731680.
Rong J, Habuchi H, Kimata K, et al. (2000). "Expression of heparan sulphate L-iduronyl 2-O-sulphotransferase in human kidney 293 cells results in increased D-glucuronyl 2-O-sulphation". Biochem. J. 346 (2): 463–8. doi:10.1042/0264-6021:3460463. PMC 1220874 . PMID 10677367.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Aquino RS, Landeira-Fernandez AM, Valente AP, et al. (2005). "Occurrence of sulfated galactans in marine angiosperms: evolutionary implications". Glycobiology. 15 (1): 11–20. doi: 10.1093/glycob/cwh138 . PMID 15317737.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID 16710414.
Xu D, Song D, Pedersen LC, Liu J (2007). "Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase". J. Biol. Chem. 282 (11): 8356–67. doi: 10.1074/jbc.M608062200 . PMID 17227754.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000153936 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040151 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9455484-5] Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (Feb 1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi: 10.1093/dnares/4.5.345 . PMID 9455484.

[entrez-6] 1 2 "Entrez Gene: HS2ST1 heparan sulfate 2-O-sulfotransferase 1".

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HS2ST1

Related Research Articles

References

Further reading