ICRF 193

ICRF 193
Names
	IUPAC name 4-[2-(3,5-Dioxo-1-piperazinyl)-1-methylpropyl]piperazine-2,6-dione
Identifiers
CAS Number	21416-68-2 ;
3D model (JSmol)	Interactive image ;
ChEMBL	ChEMBL275665 ;
ChemSpider	103034 ;
MeSH	ICRF+193
PubChem CID	115150 ;
CompTox Dashboard (EPA)	DTXSID201259810 DTXSID10943979, DTXSID201259810 ;
	InChI InChI=1S/C12H18N4O4/c1-7(15-3-9(17)13-10(18)4-15)8(2)16-5-11(19)14-12(20)6-16/h7-8H,3-6H2,1-2H3,(H,13,17,18)(H,14,19,20) Key: OBYGAPWKTPDTAS-UHFFFAOYSA-N ; InChI=1/C12H18N4O4/c1-7(15-3-9(17)13-10(18)4-15)8(2)16-5-11(19)14-12(20)6-16/h7-8H,3-6H2,1-2H3,(H,13,17,18)(H,14,19,20) Key: OBYGAPWKTPDTAS-UHFFFAOYAB;
	SMILES O=C2NC(=O)CN(C(C(N1CC(=O)NC(=O)C1)C)C)C2;
Properties
Chemical formula	C12H18N4O4
Molar mass	282.30 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Last updated June 08, 2025

ICRF 193 is a topoisomerase inhibitor.^[1]

References

↑ Robinson HM, Bratlie-Thoresen S, Brown R, Gillespie DA (May 2007). "Chk1 is required for G2/M checkpoint response induced by the catalytic topoisomerase II inhibitor ICRF-193". Cell Cycle. 6 (10): 1265–7. doi: 10.4161/cc.6.10.4225 . PMID 17495539.

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[pmid17495539-1] Robinson HM, Bratlie-Thoresen S, Brown R, Gillespie DA (May 2007). "Chk1 is required for G2/M checkpoint response induced by the catalytic topoisomerase II inhibitor ICRF-193". Cell Cycle. 6 (10): 1265–7. doi: 10.4161/cc.6.10.4225 . PMID 17495539.

[1]

Names

IUPAC name 4-[2-(3,5-Dioxo-1-piperazinyl)-1-methylpropyl]piperazine-2,6-dione
Identifiers
CAS Number	21416-68-2 ^Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL275665 ^Y
ChemSpider	103034 ^Y
MeSH	ICRF+193
PubChem CID	115150
CompTox Dashboard (EPA)	DTXSID201259810 DTXSID10943979, DTXSID201259810
InChI InChI=1S/C12H18N4O4/c1-7(15-3-9(17)13-10(18)4-15)8(2)16-5-11(19)14-12(20)6-16/h7-8H,3-6H2,1-2H3,(H,13,17,18)(H,14,19,20)^Y Key: OBYGAPWKTPDTAS-UHFFFAOYSA-N^Y InChI=1/C12H18N4O4/c1-7(15-3-9(17)13-10(18)4-15)8(2)16-5-11(19)14-12(20)6-16/h7-8H,3-6H2,1-2H3,(H,13,17,18)(H,14,19,20) Key: OBYGAPWKTPDTAS-UHFFFAOYAB
SMILES O=C2NC(=O)CN(C(C(N1CC(=O)NC(=O)C1)C)C)C2
Properties
Chemical formula	C₁₂H₁₈N₄O₄
Molar mass	282.30 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Y verify (what is ^YN ?) Infobox references