IFIT1

IFIT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4HOU
Identifiers
Aliases	IFIT1 , C56, G10P1, IFI-56, IFI-56K, IFI56, IFIT-1, IFNAI1, ISG56, P56, RNM561, interferon induced protein with tetratricopeptide repeats 1
External IDs	OMIM: 147690 MGI: 2148249 HomoloGene: 78213 GeneCards: IFIT1
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	34,618,143 bp
RNA expression pattern
	Top expressed in
	pons; ; trigeminal ganglion; ; biceps brachii; ; glomerulus; ; metanephric glomerulus; ; palpebral conjunctiva; ; subthalamic nucleus; ; germinal epithelium; ; amniotic fluid; ; parietal pleura;
	Top expressed in
	jejunum; ; secondary oocyte; ; ileum; ; interventricular septum; ; duodenum; ; colon; ; Paneth cell; ; sexually immature organism; ; left colon; ; blood;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; RNA binding ;
Cellular component	cytoplasm ; host cell ; cytosol ;
Biological process	negative regulation of helicase activity ; response to virus ; positive regulation of viral genome replication ; negative regulation of viral genome replication ; negative regulation of defense response to virus by host ; cellular response to type I interferon ; viral process ; intracellular transport of viral protein in host cell ; negative regulation of protein binding ; type I interferon signaling pathway ; innate immune response ; regulation of defense response to virus ; cellular response to exogenous dsRNA ; immune system process ; defense response to virus ; response to bacterium ; cellular response to interferon-beta ;
	Sources:Amigo / QuickGO
Orthologs
	3434
	112419
	n/a
	ENSMUSG00000067297
	P09914
	Q3U687
	NM_001548 ; NM_001270927 ; NM_001270928 ; NM_001270929 ; NM_001270930
	NM_053217 ; NM_001362130
	NP_001257856 ; NP_001257857 ; NP_001257858 ; NP_001257859 ; NP_001539
	NP_444447 ; NP_001349059
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Interferon-induced protein with tetratricopeptide repeats 1 is a protein that in humans is encoded by the IFIT1 gene.^[4]^[5]^[6]

Related Research Articles

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Protein kinase, interferon-inducible double stranded RNA dependent activator, also known as interferon-inducible double stranded RNA-dependent protein kinase activator A or Protein ACTivator of the interferon-induced protein kinase (PACT) is a protein that in humans is encoded by the PRKRA gene. PACT heterodimerizes with and activates protein kinase R. PRKRA mutations have been linked to a rare form of dystonia parkinsonism.

Interferon alpha-inducible protein 27 is a protein that in humans is encoded by the IFI27 gene.

Interferon-induced protein with tetratricopeptide repeats 2 or IFIT2 is a protein found in humans which is encoded by the IFIT2 gene.

Interferon-induced transmembrane protein 1 is a protein that in humans is encoded by the IFITM1 gene. IFITM1 has also recently been designated CD225. This protein has several additional names: fragilis, IFI17 [interferon-induced protein 17], 9-27 [Interferon-inducible protein 9-27] and Leu13.

Interferon alpha-17 is a protein that in humans is encoded by the IFNA17 gene.

Interferon alpha-inducible protein 6 is a protein that in humans is encoded by the IFI6 gene.

Interferon alpha-14 is a protein that in humans is encoded by the IFNA14 gene.

Interferon-induced GTP-binding protein Mx2 is a protein that in humans is encoded by the MX2 gene.

Interferon-induced transmembrane protein 3 (IFITM3) is a protein that in humans is encoded by the IFITM3 gene. It plays a critical role in the immune system's defense against Swine Flu, where heightened levels of IFITM3 keep viral levels low, and the removal of IFITM3 allows the virus to multiply unchecked. This observation has been further advanced by a recent study from Paul Kellam's lab that shows that a single nucleotide polymorphism in the human IFITM3 gene purported to increase influenza susceptibility is overrepresented in people hospitalised with pandemic H1N1. The prevalence of this mutation is thought to be approximately 1/400 in European populations.

Interferon alpha-8 is a protein that in humans is encoded by the IFNA8 gene.

59 kDa 2'-5'-oligoadenylate synthetase-like protein is an enzyme that in humans is encoded by the OASL gene.

Interferon-induced protein with tetratricopeptide repeats 3 is a protein that in humans is encoded by the IFIT3 gene.

Interferon alpha-6 is a protein that in humans is encoded by the IFNA6 gene.

Interferon alpha-1/13, also known as IFN-alpha-1/13, is a protein that in humans is encoded by the IFNA1 and IFNA13 genes.

IFIT proteins are produced in the human body and are supposed to confer immunity against viral infection. These proteins are generally produced during viral infection; Interferon (IFN) treatment; and during pathogen recognition by the immune system during infections.

References

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000067297 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lafage M, Clauss I, Couez D, Simonetti J, Wathelet MG, Huez G (Jul 1992). "The interferon- and virus-inducible IFI-56K and IFI-54K genes are located on human chromosome 10 at bands q23-q24". Genomics. 13 (2): 458–60. doi:10.1016/0888-7543(92)90272-T. PMID 1377167.
↑ Wathelet MG, Clauss IM, Content J, Huez GA (Jun 1988). "The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family". FEBS Lett. 231 (1): 164–71. doi: 10.1016/0014-5793(88)80724-5 . PMID 3360121. S2CID 22937671.
↑ "Entrez Gene: IFIT1 interferon-induced protein with tetratricopeptide repeats 1".

Wathelet MG, Clauss IM, Nols CB, et al. (1988). "New inducers revealed by the promoter sequence analysis of two interferon-activated human genes". Eur. J. Biochem. 169 (2): 313–21. doi: 10.1111/j.1432-1033.1987.tb13614.x . PMID 3121313.
Wathelet MG, Szpirer J, Nols CB, et al. (1988). "Cloning and chromosomal location of human genes inducible by type I interferon". Somat. Cell Mol. Genet. 14 (5): 415–26. doi:10.1007/BF01534709. PMID 3175763. S2CID 42406993.
Kusari J, Szabo P, Grzeschik KH, Sen GC (1987). "Chromosomal localization of the interferon-inducible human gene encoding mRNA 561". J. Interferon Res. 7 (1): 53–9. doi:10.1089/jir.1987.7.53. PMID 3585080.
Wathelet M, Moutschen S, Defilippi P, et al. (1986). "Molecular cloning, full-length sequence and preliminary characterization of a 56-kDa protein induced by human interferons". Eur. J. Biochem. 155 (1): 11–7. doi: 10.1111/j.1432-1033.1986.tb09452.x . PMID 3753936.
Chebath J, Merlin G, Metz R, et al. (1983). "Interferon-induced 56,000 Mr protein and its mRNA in human cells: molecular cloning and partial sequence of the cDNA". Nucleic Acids Res. 11 (5): 1213–26. doi:10.1093/nar/11.5.1213. PMC 325791 . PMID 6186990.
Rebouillat D, Marié I, Hovanessian AG (1998). "Molecular cloning and characterization of two related and interferon-induced 56-kDa and 30-kDa proteins highly similar to 2'-5' oligoadenylate synthetase". Eur. J. Biochem. 257 (2): 319–30. doi: 10.1046/j.1432-1327.1998.2570319.x . PMID 9826176.
Guo J, Sen GC (2000). "Characterization of the Interaction between the Interferon-Induced Protein P56 and the Int6 Protein Encoded by a Locus of Insertion of the Mouse Mammary Tumor Virus". J. Virol. 74 (4): 1892–9. doi:10.1128/JVI.74.4.1892-1899.2000. PMC 111667 . PMID 10644362.
Guo J, Peters KL, Sen GC (2000). "Induction of the human protein P56 by interferon, double-stranded RNA, or virus infection". Virology. 267 (2): 209–19. doi: 10.1006/viro.1999.0135 . PMID 10662616.
Guo J, Hui DJ, Merrick WC, Sen GC (2001). "A new pathway of translational regulation mediated by eukaryotic initiation factor 3". EMBO J. 19 (24): 6891–9. doi:10.1093/emboj/19.24.6891. PMC 305884 . PMID 11118224.
Patzwahl R, Meier V, Ramadori G, Mihm S (2001). "Enhanced Expression of Interferon-Regulated Genes in the Liver of Patients with Chronic Hepatitis C Virus Infection: Detection by Suppression-Subtractive Hybridization". J. Virol. 75 (3): 1332–8. doi:10.1128/JVI.75.3.1332-1338.2001. PMC 114039 . PMID 11152506.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gavrilov BG, Monastyrskaia GS, Velikodvorskaia TV, et al. (2003). "[Late activation of interferon-induced genes IFI-54k and IFI-56k in human RH cells infected with tick-borne encephalitis virus]". Bioorg. Khim. 29 (2): 175–80. doi:10.1023/a:1023260415910. PMID 12708317. S2CID 34300356.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Terenzi F, Hui DJ, Merrick WC, Sen GC (2006). "Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56". J. Biol. Chem. 281 (45): 34064–71. doi: 10.1074/jbc.M605771200 . PMID 16973618.

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[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000067297 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1377167-4] Lafage M, Clauss I, Couez D, Simonetti J, Wathelet MG, Huez G (Jul 1992). "The interferon- and virus-inducible IFI-56K and IFI-54K genes are located on human chromosome 10 at bands q23-q24". Genomics. 13 (2): 458–60. doi:10.1016/0888-7543(92)90272-T. PMID 1377167.

[pmid3360121-5] Wathelet MG, Clauss IM, Content J, Huez GA (Jun 1988). "The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family". FEBS Lett. 231 (1): 164–71. doi: 10.1016/0014-5793(88)80724-5 . PMID 3360121. S2CID 22937671.

[entrez-6] "Entrez Gene: IFIT1 interferon-induced protein with tetratricopeptide repeats 1".

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IFIT1

Related Research Articles

References

Further reading