IK (gene)

IK
Identifiers
Aliases	IK , CSA2, RED, IK cytokine, down-regulator of HLA II, RER, IK cytokine
External IDs	OMIM: 600549; MGI: 1345142; HomoloGene: 36193; GeneCards: IK; OMA:IK - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q31.3 Start 140,647,058 bp [1] End 140,662,480 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 B2 Start 36,877,709 bp [2] End 36,890,692 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii bronchial epithelial cell right uterine tube sural nerve Achilles tendon olfactory zone of nasal mucosa epithelium of nasopharynx left testis right testis ganglionic eminence Top expressed in genital tubercle tail of embryo retinal pigment epithelium Paneth cell ciliary body fossa condyle iris supraoptic nucleus Epithelium of choroid plexus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding identical protein binding Cellular component nuclear speck nuclear chromosome mitotic spindle pole spindle pole nucleoplasm spliceosomal complex chromosome cytoplasm cytoskeleton nucleus U2-type precatalytic spliceosome Biological process mitotic cell cycle mitotic spindle assembly checkpoint signaling protein localization to kinetochore mRNA processing RNA splicing viral process mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3550 24010 Ensembl ENSG00000113141 ENSMUSG00000024474 UniProt Q13123 Q95HA6 Q9Z1M8 RefSeq (mRNA) NM_006083 NM_011879 RefSeq (protein) NP_006074 NP_006074.2 NP_036009 Location (UCSC) Chr 5: 140.65 – 140.66 Mb Chr 18: 36.88 – 36.89 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein Red is a protein that in humans is encoded by the IK gene. ^{[5] [6]}

The protein encoded by this gene was identified by its RED repeat, a stretch of repeated arginine, glutamic acid and aspartic acid residues. The protein localizes to discrete dots within the nucleus, excluding the nucleolus. Its function is unknown. This gene maps to chromosome 5; however, a pseudogene may exist on chromosome 2. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000113141 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024474 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Krief P, Augery-Bourget Y, Plaisance S, Merck MF, Assier E, Tanchou V, Billard M, Boucheix C, Jasmin C, Azzarone B (Dec 1994). "A new cytokine (IK) down-regulating HLA class II: monoclonal antibodies, cloning and chromosome localization". Oncogene. 9 (12): 3449–56. PMID   7970704.
6. "Entrez Gene: IK IK cytokine, down-regulator of HLA II".

Further reading

• Cao LX, Le Bousse-Kerdiles MC, Clay D, et al. (1997). "Implication of a new molecule IK in CD34+ hematopoietic progenitor cell proliferation and differentiation". Blood. 89 (10): 3615–23. doi: 10.1182/blood.V89.10.3615 . PMID   9160666.
• Assier E, Bouzinba-Segard H, Stolzenberg MC, et al. (1999). "Isolation, sequencing and expression of RED, a novel human gene encoding an acidic-basic dipeptide repeat". Gene. 230 (2): 145–54. doi:10.1016/S0378-1119(99)00066-9. PMID   10216252.
• Willers J, Häffner A, Zepter K, et al. (2001). "The interferon inhibiting cytokine IK is overexpressed in cutaneous T cell lymphoma derived tumor cells that fail to upregulate major histocompatibility complex class II upon interferon-gamma stimulation". J. Invest. Dermatol. 116 (6): 874–9. doi: 10.1046/j.1523-1747.2001.01339.x . PMID   11407974.