IK (gene)

IK
Identifiers
Aliases	IK , CSA2, RED, IK cytokine, down-regulator of HLA II, RER, IK cytokine
External IDs	OMIM: 600549 MGI: 1345142 HomoloGene: 36193 GeneCards: IK
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q31.3 Start 140,647,058 bp [1] End 140,662,480 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 B2 Start 36,744,656 bp [2] End 36,757,639 bp [2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • identical protein binding Cellular component • nuclear speck • nuclear chromosome • mitotic spindle pole • spindle pole • nucleoplasm • spliceosomal complex • chromosome • cytoplasm • cytoskeleton • cell nucleus • U2-type precatalytic spliceosome Biological process • GO:0007067 mitotic cell cycle • mitotic spindle assembly checkpoint • protein localization to kinetochore • mRNA processing • RNA splicing • GO:0022415 viral process • mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3550	24010
Ensembl	ENSG00000113141	ENSMUSG00000024474
UniProt	Q13123 Q95HA6	Q9Z1M8
RefSeq (mRNA)	NM_006083	NM_011879
RefSeq (protein)	NP_006074 NP_006074.2	NP_036009
Location (UCSC)	Chr 5: 140.65 – 140.66 Mb	Chr 18: 36.74 – 36.76 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Protein Red is a protein that in humans is encoded by the IK gene. ^{[5] [6]}

The protein encoded by this gene was identified by its RED repeat, a stretch of repeated arginine, glutamic acid and aspartic acid residues. The protein localizes to discrete dots within the nucleus, excluding the nucleolus. Its function is unknown. This gene maps to chromosome 5; however, a pseudogene may exist on chromosome 2. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000113141 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024474 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Krief P, Augery-Bourget Y, Plaisance S, Merck MF, Assier E, Tanchou V, Billard M, Boucheix C, Jasmin C, Azzarone B (Dec 1994). "A new cytokine (IK) down-regulating HLA class II: monoclonal antibodies, cloning and chromosome localization". Oncogene. 9 (12): 3449–56. PMID   7970704.
6. "Entrez Gene: IK IK cytokine, down-regulator of HLA II".

Further reading

• Cao LX, Le Bousse-Kerdiles MC, Clay D, et al. (1997). "Implication of a new molecule IK in CD34+ hematopoietic progenitor cell proliferation and differentiation". Blood. 89 (10): 3615–23. doi:10.1182/blood.V89.10.3615. PMID   9160666.
• Assier E, Bouzinba-Segard H, Stolzenberg MC, et al. (1999). "Isolation, sequencing and expression of RED, a novel human gene encoding an acidic-basic dipeptide repeat". Gene. 230 (2): 145–54. doi:10.1016/S0378-1119(99)00066-9. PMID   10216252.
• Willers J, Häffner A, Zepter K, et al. (2001). "The interferon inhibiting cytokine IK is overexpressed in cutaneous T cell lymphoma derived tumor cells that fail to upregulate major histocompatibility complex class II upon interferon-gamma stimulation". J. Invest. Dermatol. 116 (6): 874–9. doi:10.1046/j.1523-1747.2001.01339.x. PMID   11407974.