INPP5A

INPP5A
Identifiers
Aliases	INPP5A , 5PTASE, inositol polyphosphate-5-phosphatase A
External IDs	OMIM: 600106 MGI: 2686961 HomoloGene: 4045 GeneCards: INPP5A
Gene location (Human)
Chr.	Chromosome 10 (human)
End	132,783,480 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	139,159,568 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; middle temporal gyrus; ; popliteal artery; ; sperm; ; external globus pallidus; ; right ventricle; ; gastric mucosa; ; putamen; ; right coronary artery; ; Brodmann area 23;
	Top expressed in
	right ventricle; ; cerebellar vermis; ; interventricular septum; ; plantaris muscle; ; ascending aorta; ; extensor digitorum longus muscle; ; soleus muscle; ; extraocular muscle; ; thoracic diaphragm; ; medial dorsal nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	PH domain binding ; inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity ; protein binding ; hydrolase activity ; inositol-1,4,5-trisphosphate 5-phosphatase activity ; inositol-polyphosphate 5-phosphatase activity ;
Cellular component	plasma membrane ; membrane ; intracellular anatomical structure ;
Biological process	inositol phosphate metabolic process ; phosphatidylinositol dephosphorylation ; inositol phosphate-mediated signaling ; inositol phosphate dephosphorylation ; dephosphorylation ;
	Sources:Amigo / QuickGO
Orthologs
	3632
	212111
	ENSG00000068383
	ENSMUSG00000025477
	Q14642 ; Q5T1B3
	Q7TNC9
	NM_005539 ; NM_001321042
	NM_001127363 ; NM_183144 ; NM_001355162
	NP_001307971 ; NP_005530
	NP_001120835 ; NP_001342091 ; NP_898967
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 18, 2022

Type I inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5A gene.^[5]^[6]

The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation.^[6]

Related Research Articles

Inositol polyphosphate 5-phosphatase OCRL-1, also known as Lowe oculocerebrorenal syndrome protein, is an enzyme encoded by the OCRL gene located on the X chromosome in humans.

Inositol-trisphosphate 3-kinase B is an enzyme that in humans is encoded by the ITPKB gene.

Src homology 2 (SH2) domain containing inositol polyphosphate 5-phosphatase 1(SHIP1) is an enzyme with phosphatase activity. SHIP1 is structured by multiple domain and is encoded by the INPP5D gene in humans. SHIP1 is expressed predominantly by hematopoietic cells but also, for example, by osteoblasts and endothelial cells. This phosphatase is important for the regulation of cellular activation. Not only catalytic but also adaptor activities of this protein are involved in this process. Its movement from the cytosol to the cytoplasmic membrane, where predominantly performs its function, is mediated by tyrosine phosphorylation of the intracellular chains of cell surface receptors that SHIP1 binds. Insufficient regulation of SHIP1 leads to different pathologies.

Type I inositol-3,4-bisphosphate 4-phosphatase is an enzyme that in humans is encoded by the INPP4A gene.

Inositol hexakisphosphate kinase 2 is an enzyme that in humans is encoded by the IP6K2 gene.

Putative adenosylhomocysteinase 2 is an enzyme that in humans is encoded by the AHCYL1 gene.

Type II inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5B gene.

Diphosphoinositol polyphosphate phosphohydrolase 3-beta is an enzyme that in humans is encoded by the NUDT11 gene.

Multiple inositol polyphosphate phosphatase 1 is an enzyme that in humans is encoded by the MINPP1 gene.

Inositol-tetrakisphosphate 1-kinase is an enzyme that in humans is encoded by the ITPK1 gene.

Inositol polyphosphate 1-phosphatase is an enzyme that, in humans, is encoded by the INPP1 gene. INPP1 encodes the enzyme inositol polyphosphate-1-phosphatase, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate.

Inositol hexakisphosphate kinase 1 is an enzyme that in humans is encoded by the IP6K1 gene.

Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A is an enzyme that in humans is encoded by the INPP5J gene.

Membrane-spanning 4-domains subfamily A member 3 is a protein that in humans is encoded by the MS4A3 gene.

Inositol 1,4,5-trisphosphate receptor, type 2, also known as ITPR2, is a protein which in humans is encoded by the ITPR2 gene. The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel.

72 kDa inositol polyphosphate 5-phosphatase, also known as phosphatidylinositol-4,5-bisphosphate 5-phosphatase or Pharbin, is an enzyme that in humans is encoded by the INPP5E gene.

Inositol polyphosphate-4-phosphatase, type II, 105kDa is a protein that in humans is encoded by the INPP4B gene.

The enzyme Inositol-polyphosphate 5-phosphatase (EC 3.1.3.56, systematic name 1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase; other names type I inositol-polyphosphate phosphatase, inositol trisphosphate phosphomonoesterase, InsP₃/Ins(1,3,4,5)P₄ 5-phosphatase, inosine triphosphatase, D-myo-inositol 1,4,5-triphosphate 5-phosphatase, D-myo-inositol 1,4,5-trisphosphate 5-phosphatase, L-myo-inositol 1,4,5-trisphosphate-monoesterase, inositol phosphate 5-phosphomonoesterase, inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase, Ins(1,4,5)P₃ 5-phosphataseD-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase, inositol 1,4,5-trisphosphate phosphatase, inositol polyphosphate-5-phosphatase, myo-inositol-1,4,5-trisphosphate 5-phosphatase, inositol-1,4,5-trisphosphate 5-phosphatase) catalyses the following reaction

Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase is an enzyme with systematic name 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase, that has two isoforms: SHIP1 and SHIP2 (INPPL1).

Inositol polyphosphate-5-phosphatase F is a protein that in humans is encoded by the INPP5F gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000068383 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025477 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ De Smedt F, Verjans B, Mailleux P, Erneux C (Jul 1994). "Cloning and expression of human brain type I inositol 1,4,5-trisphosphate 5-phosphatase. High levels of mRNA in cerebellar Purkinje cells". FEBS Lett. 347 (1): 69–72. doi: 10.1016/0014-5793(94)00509-5 . PMID 8013665. S2CID 4936881.
1 2 "Entrez Gene: INPP5A inositol polyphosphate-5-phosphatase, 40kDa".

Laxminarayan KM, Chan BK, Tetaz T, et al. (1994). "Characterization of a cDNA encoding the 43-kDa membrane-associated inositol-polyphosphate 5-phosphatase". J. Biol. Chem. 269 (25): 17305–10. doi: 10.1016/S0021-9258(17)32555-3 . PMID 8006039.
Mitchell CA, Speed CJ, Nicholl J, Sutherland GR (1996). "Chromosomal mapping of the gene (INPP5A) encoding the 43-kDa membrane-associated inositol polyphosphate 5-phosphatase to 10q26.3 by fluorescence in situ hybridization". Genomics. 31 (1): 139–40. doi:10.1006/geno.1996.0023. PMID 8808294.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Auethavekiat V, Abrams CS, Majerus PW (1997). "Phosphorylation of platelet pleckstrin activates inositol polyphosphate 5-phosphatase I." J. Biol. Chem. 272 (3): 1786–90. doi: 10.1074/jbc.272.3.1786 . PMID 8999861.
Campbell JK, Gurung R, Romero S, et al. (1998). "Activation of the 43 kDa inositol polyphosphate 5-phosphatase by 14-3-3zeta". Biochemistry. 36 (49): 15363–70. doi:10.1021/bi9708085. PMID 9398266.
Lee SH, Davison JA, Vidal SM, Belouchi A (2001). "Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors". Mamm. Genome. 12 (2): 157–62. doi:10.1007/s003350010247. PMID 11210186. S2CID 22368753.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Hartmann TB, Thiel D, Dummer R, et al. (2004). "SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma". Br. J. Dermatol. 150 (2): 252–8. doi:10.1111/j.1365-2133.2004.05651.x. PMID 14996095. S2CID 42495130.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi: 10.1038/nature02462 . PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000068383 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025477 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8013665-5] De Smedt F, Verjans B, Mailleux P, Erneux C (Jul 1994). "Cloning and expression of human brain type I inositol 1,4,5-trisphosphate 5-phosphatase. High levels of mRNA in cerebellar Purkinje cells". FEBS Lett. 347 (1): 69–72. doi: 10.1016/0014-5793(94)00509-5 . PMID 8013665. S2CID 4936881.

[entrez-6] 1 2 "Entrez Gene: INPP5A inositol polyphosphate-5-phosphatase, 40kDa".

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INPP5A

Related Research Articles

References

Further reading