INPP5A

INPP5A
Identifiers
Aliases	INPP5A , 5PTASE, inositol polyphosphate-5-phosphatase A
External IDs	OMIM: 600106; MGI: 2686961; HomoloGene: 4045; GeneCards: INPP5A; OMA:INPP5A - orthologs
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q26.3 Start 132,537,787 bp [1] End 132,783,480 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 F4 Start 138,969,025 bp [2] End 139,159,568 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus saphenous vein myocardium of left ventricle middle temporal gyrus popliteal artery tibial arteries sperm external globus pallidus right ventricle gastric mucosa Top expressed in Ileal epithelium cardiac muscle tissue of left ventricle lobe of cerebellum right ventricle cerebellar vermis interventricular septum plantaris muscle ascending aorta extensor digitorum longus muscle soleus muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function PH domain binding inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity protein binding hydrolase activity inositol-1,4,5-trisphosphate 5-phosphatase activity inositol-polyphosphate 5-phosphatase activity Cellular component plasma membrane membrane intracellular anatomical structure Biological process inositol phosphate metabolic process phosphatidylinositol dephosphorylation inositol phosphate-mediated signaling inositol phosphate dephosphorylation dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3632 212111 Ensembl ENSG00000068383 ENSMUSG00000025477 UniProt Q14642 Q5T1B3 Q7TNC9 RefSeq (mRNA) NM_005539 NM_001321042 NM_001127363 NM_183144 NM_001355162 RefSeq (protein) NP_001307971 NP_005530 NP_001120835 NP_001342091 NP_898967 Location (UCSC) Chr 10: 132.54 – 132.78 Mb Chr 7: 138.97 – 139.16 Mb PubMed search [3] [4]
Wikidata
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Type I inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5A gene. ^{[5] [6]}

The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins (1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000068383 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025477 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. De Smedt F, Verjans B, Mailleux P, Erneux C (Jul 1994). "Cloning and expression of human brain type I inositol 1,4,5-trisphosphate 5-phosphatase. High levels of mRNA in cerebellar Purkinje cells". FEBS Lett. 347 (1): 69–72. doi:10.1016/0014-5793(94)00509-5. PMID   8013665. S2CID   4936881.
6. "Entrez Gene: INPP5A inositol polyphosphate-5-phosphatase, 40kDa".

Further reading

• Laxminarayan KM, Chan BK, Tetaz T, et al. (1994). "Characterization of a cDNA encoding the 43-kDa membrane-associated inositol-polyphosphate 5-phosphatase". J. Biol. Chem. 269 (25): 17305–10. doi: 10.1016/S0021-9258(17)32555-3 . PMID   8006039.
• Mitchell CA, Speed CJ, Nicholl J, Sutherland GR (1996). "Chromosomal mapping of the gene (INPP5A) encoding the 43-kDa membrane-associated inositol polyphosphate 5-phosphatase to 10q26.3 by fluorescence in situ hybridization". Genomics. 31 (1): 139–40. doi:10.1006/geno.1996.0023. PMID   8808294.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Auethavekiat V, Abrams CS, Majerus PW (1997). "Phosphorylation of platelet pleckstrin activates inositol polyphosphate 5-phosphatase I." J. Biol. Chem. 272 (3): 1786–90. doi: 10.1074/jbc.272.3.1786 . PMID   8999861.
• Campbell JK, Gurung R, Romero S, et al. (1998). "Activation of the 43 kDa inositol polyphosphate 5-phosphatase by 14-3-3zeta". Biochemistry. 36 (49): 15363–70. doi:10.1021/bi9708085. PMID   9398266.
• Lee SH, Davison JA, Vidal SM, Belouchi A (2001). "Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors". Mamm. Genome. 12 (2): 157–62. doi:10.1007/s003350010247. PMID   11210186. S2CID   22368753.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Hartmann TB, Thiel D, Dummer R, et al. (2004). "SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma". Br. J. Dermatol. 150 (2): 252–8. doi:10.1111/j.1365-2133.2004.05651.x. PMID   14996095. S2CID   42495130.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi: 10.1038/nature02462 . PMID   15164054.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.