INTS1

Last updated
INTS1
Identifiers
Aliases INTS1 , INT1, NET28, integrator complex subunit 1, NDCAGF
External IDs OMIM: 611345; MGI: 1915760; HomoloGene: 53111; GeneCards: INTS1; OMA:INTS1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

26173

68510

Ensembl

ENSG00000164880

ENSMUSG00000029547

UniProt

Q8N201

Q6P4S8

RefSeq (mRNA)

NM_001080453

NM_026748

RefSeq (protein)

NP_001073922

NP_081024

Location (UCSC) Chr 7: 1.47 – 1.5 Mb Chr 5: 139.74 – 139.76 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Integrator complex subunit 1 is a protein that in humans is encoded by the INTS1 gene. [5]

Contents

Function

INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000164880 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029547 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ "Entrez Gene: Integrator complex subunit 1" . Retrieved 2016-06-11.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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