INTS1

INTS1
Identifiers
Aliases	INTS1 , INT1, NET28, integrator complex subunit 1, NDCAGF
External IDs	OMIM: 611345 MGI: 1915760 HomoloGene: 53111 GeneCards: INTS1
Gene location (Human)
Chr.	Chromosome 7 (human)
End	1,504,389 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	139,761,429 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; right uterine tube; ; right lobe of liver; ; gastrocnemius muscle; ; sural nerve; ; cingulate gyrus; ; body of pancreas; ; canal of the cervix;
	Top expressed in
	spermatocyte; ; superior frontal gyrus; ; yolk sac; ; spermatid; ; thymus; ; lip; ; cerebellar cortex; ; interventricular septum; ; facial motor nucleus; ; secondary oocyte;
	More reference expression data
	n/a
Orthologs
	26173
	68510
	ENSG00000164880
	ENSMUSG00000029547
	Q8N201
	Q6P4S8
	NM_001080453
	NM_026748
	NP_001073922
	NP_081024
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Integrator complex subunit 1 is a protein that in humans is encoded by the INTS1 gene. ^[5]

Function

INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).

Related Research Articles

Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform is an enzyme that in humans is encoded by the PHKA1 gene. It is the muscle isoform of Phosphorylase kinase (PhK).

Integrator complex subunit 9 is a protein that in Humans is encoded by the INTS9 gene.

THO complex subunit 2 is a protein that in humans is encoded by the THOC2 gene.

Integrator complex subunit 3 is a protein that in humans is encoded by the INTS3 gene.

Integrator complex subunit 7 is a protein that in humans is encoded by the INTS7 gene.

Integrator complex subunit 8 is a protein that in humans is encoded by the INTS8 gene.

Integrator complex subunit 12 (Int12) also known as PHD finger protein 22 (PHF22) is a protein that in humans is encoded by the INTS12 gene.

Ribonuclease H2 subunit C is a protein that in humans is encoded by the RNASEH2C gene. RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits, and degrades the RNA of RNA:DNA hybrids.

Mitochondrial ribosomal protein L13 is a protein that in humans is encoded by the MRPL13 gene.

WD repeat domain 18 is a protein that in humans is encoded by the WDR18 gene.

Integrator complex subunit 5 is a protein that in humans is encoded by the INTS5 gene.

Mediator complex subunit 9 (Med9) is a protein that in humans is encoded by the MED9 gene.

Mediator complex subunit 10 (Med10) is a protein that in humans is encoded by the MED10 gene.

Mediator complex subunit 11 (Med11) is a protein that in humans is encoded by the MED11 gene.

Mediator complex subunit 18 (Med18) is a protein that in humans is encoded by the MED18 gene.

Mitochondrial ribosomal protein S2 (MRPS2), otherwise known as uS2m, is a protein that in humans is encoded by the MRPS2 gene.

Mitochondrial ribosomal protein S9 (MRPS9), otherwise known as uS9m, is a protein that in humans is encoded by the MRPS9 gene.

Poly(A) binding protein interacting protein 2B is a protein that in humans is encoded by the PAIP2B gene.

CCR4-NOT transcription complex subunit 10 is a protein that in humans is encoded by the CNOT10 gene. It is a subunit of the CCR4-Not deadenylase complex.

CCR4-NOT transcription complex subunit 11 is a protein that in humans is encoded by the CNOT11 gene. It is a subunit of the CCR4-Not deadenylase complex.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000164880 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029547 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Integrator complex subunit 1" . Retrieved 2016-06-11.

INTS1

Contents

Function

Related Research Articles

References

Further reading