INTS12

Last updated
INTS12
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases INTS12 , INT12, PHF22, SBBI22, integrator complex subunit 12
External IDs OMIM: 611355; MGI: 1919043; HomoloGene: 32474; GeneCards: INTS12; OMA:INTS12 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001142471
NM_020395

NM_027927

RefSeq (protein)

NP_001135943
NP_065128
NP_001135943.1
NP_065128.2

NP_082203

Location (UCSC)n/a Chr 3: 132.8 – 132.82 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Integrator complex subunit 12 (Int12) also known as PHD finger protein 22 (PHF22) is a protein that in humans is encoded by the INTS12 gene. [4]

INTS12 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1) and U2 (RNU2) [4] [5]

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References

  1. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028016 Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. 1 2 "Entrez Gene: integrator complex subunit 12" . Retrieved 2011-08-30.
  5. Baillat D, Hakimi MA, et al. (2005). "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II". Cell. 123 (2): 265–76. doi: 10.1016/j.cell.2005.08.019 . PMID   16239144. S2CID   18069461.

Further reading