INTS12

INTS12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WEV
Identifiers
Aliases	INTS12 , INT12, PHF22, SBBI22, integrator complex subunit 12
External IDs	OMIM: 611355; MGI: 1919043; HomoloGene: 32474; GeneCards: INTS12; OMA:INTS12 - orthologs
Gene location (Mouse) Chr. Chromosome 3 (mouse) [1] Band 3|3 G3 Start 132,797,601 bp [1] End 132,816,749 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte right ventricle islet of Langerhans gastrocnemius muscle jejunal mucosa triceps brachii muscle ganglionic eminence biceps brachii Achilles tendon Top expressed in secondary oocyte genital tubercle zygote primary oocyte tail of embryo granulocyte otic placode medial ganglionic eminence epiblast maxillary prominence More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding metal ion binding Cellular component integrator complex nucleoplasm nucleus Biological process snRNA processing snRNA transcription by RNA polymerase II snRNA 3'-end processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57117 71793 Ensembl n/a ENSMUSG00000028016 UniProt Q96CB8 Q9D168 RefSeq (mRNA) NM_001142471 NM_020395 NM_027927 RefSeq (protein) NP_001135943 NP_065128 NP_001135943.1 NP_065128.2 NP_082203 Location (UCSC) n/a Chr 3: 132.8 – 132.82 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Integrator complex subunit 12 (Int12) also known as PHD finger protein 22 (PHF22) is a protein that in humans is encoded by the INTS12 gene. ^[4]

INTS12 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1) and U2 (RNU2) ^{[4] [5]}

References

1. GRCm38: Ensembl release 89: ENSMUSG00000028016 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: integrator complex subunit 12" . Retrieved 2011-08-30.
5. Baillat D, Hakimi MA, et al. (2005). "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II". Cell. 123 (2): 265–76. doi: 10.1016/j.cell.2005.08.019 . PMID   16239144. S2CID   18069461.

Further reading

• Kalsi G, Kuo PH, Aliev F, et al. (2010). "A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts". Hum. Mol. Genet. 19 (12): 2497–506. doi:10.1093/hmg/ddq112. PMC   2876884 . PMID   20332099.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.