IPO4

IPO4
Identifiers
Aliases	IPO4 , Imp4, importin 4
External IDs	MGI: 1923001 HomoloGene: 5835 GeneCards: IPO4
Gene location (Mouse) Chr. Chromosome 14 (mouse) [1] Band 14 C3|14 28.19 cM Start 55,862,857 bp [1] End 55,873,414 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas gastrocnemius muscle right uterine tube Right adrenal gland sural nerve anterior pituitary Left adrenal gland kidney skeletal muscle tissue bone marrow cells Top expressed in internal carotid artery external carotid artery seminiferous tubule fossa condyle vas deferens morula arcuate nucleus paraventricular nucleus of hypothalamus substantia nigra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nuclear localization sequence binding Cellular component cytoplasm nuclear membrane nuclear pore membrane nuclear periphery nucleus protein-containing complex Biological process protein transport DNA replication-dependent chromatin assembly intracellular protein transport ribosomal protein import into nucleus NLS-bearing protein import into nucleus transport protein import into nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79711 75751 Ensembl n/a ENSMUSG00000002319 UniProt Q8TEX9 Q8VI75 RefSeq (mRNA) NM_024658 NM_024267 NM_001360078 RefSeq (protein) NP_078934 NP_077229 NP_001347007 Location (UCSC) n/a Chr 14: 55.86 – 55.87 Mb PubMed search [2] [3]
Wikidata
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Importin-4 is a protein that in humans is encoded by the IPO4 gene. ^{[4] [5]}

References

1. GRCm38: Ensembl release 89: ENSMUSG00000002319 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Jakel S, Mingot JM, Schwarzmaier P, Hartmann E, Gorlich D (Feb 2002). "Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains". EMBO J. 21 (3): 377–86. doi:10.1093/emboj/21.3.377. PMC   125346 . PMID   11823430.
5. "Entrez Gene: IPO4 importin 4".

Further reading

• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Miyauchi Y, Michigami T, Sakaguchi N, et al. (2006). "Importin 4 is responsible for ligand-independent nuclear translocation of vitamin D receptor". J. Biol. Chem. 280 (49): 40901–8. doi: 10.1074/jbc.M509347200 . PMID   16207705.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Lischka P, Sorg G, Kann M, et al. (2003). "A Nonconventional Nuclear Localization Signal within the UL84 Protein of Human Cytomegalovirus Mediates Nuclear Import via the Importin α/β Pathway". J. Virol. 77 (6): 3734–48. doi:10.1128/JVI.77.6.3734-3748.2003. PMC   149505 . PMID   12610148.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.