IPO7

IPO7
Identifiers
Aliases	IPO7 , Imp7, RANBP7, importin 7
External IDs	OMIM: 605586 MGI: 2152414 HomoloGene: 4659 GeneCards: IPO7
Gene location (Human)
Chr.	Chromosome 11 (human)
End	9,448,127 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	109,655,816 bp
RNA expression pattern
	Top expressed in
	biceps brachii; ; lower lobe of lung; ; triceps brachii muscle; ; deltoid muscle; ; caput epididymis; ; tibialis anterior muscle; ; body of tongue; ; corpus epididymis; ; thoracic diaphragm; ; pericardium;
	Top expressed in
	parotid gland; ; temporal muscle; ; digastric muscle; ; abdominal wall; ; triceps brachii muscle; ; lacrimal gland; ; sternocleidomastoid muscle; ; primitive streak; ; medial ganglionic eminence; ; right ventricle;
	More reference expression data
	n/a
Gene ontology
Molecular function	histone binding ; protein binding ; GTPase regulator activity ; transporter activity ; SMAD binding ;
Cellular component	nuclear pore ; membrane ; nucleus ; nucleoplasm ; cytoplasm ; cytosol ; nuclear envelope ;
Biological process	protein transport ; innate immune response ; viral process ; intracellular protein transport ; signal transduction ; regulation of catalytic activity ; protein import into nucleus ; transport ; negative regulation of cyclin-dependent protein serine/threonine kinase activity ;
	Sources:Amigo / QuickGO
Orthologs
	10527
	233726
	ENSG00000205339
	ENSMUSG00000066232
	O95373
	Q9EPL8
	NM_006391
	NM_181517 ; NM_001362172
	NP_006382
	NP_852658 ; NP_001349101
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 06, 2024

Importin-7 is a protein that in humans is encoded by the IPO7 gene.^[5]^[6]

The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins.^[6]

Related Research Articles

A nuclear localization signalorsequence (NLS) is an amino acid sequence that 'tags' a protein for import into the cell nucleus by nuclear transport. Typically, this signal consists of one or more short sequences of positively charged lysines or arginines exposed on the protein surface. Different nuclear localized proteins may share the same NLS. An NLS has the opposite function of a nuclear export signal (NES), which targets proteins out of the nucleus.

Importin subunit beta-1 is a protein that in humans is encoded by the KPNB1 gene.

Importin subunit alpha-7 is a protein that in humans is encoded by the KPNA6 gene.

C-jun-amino-terminal kinase-interacting protein 1 is an enzyme that in humans is encoded by the MAPK8IP1 gene.

Histone H3.1 is a protein that in humans is encoded by the H3C2 gene.

G-protein coupled receptor 4 is a protein that in humans is encoded by the GPR4 gene.

Transportin-1 is a protein that in humans is encoded by the TNPO1 gene.

40S ribosomal protein S27a is a protein that in humans is encoded by the RPS27A gene.

Glucosidase 2 subunit beta is an enzyme that in humans is encoded by the PRKCSH gene.

LIM/homeobox protein Lhx3 is a protein that in humans is encoded by the LHX3 gene.

Homeobox protein DLX-4 is a protein that in humans is encoded by the DLX4 gene.

Vesicle-associated membrane protein 8 is a protein that in humans is encoded by the VAMP8 gene.

Nucleoporin 50 (Nup50) is a protein that in humans is encoded by the NUP50 gene.

cAMP-dependent protein kinase catalytic subunit gamma is an enzyme that in humans is encoded by the PRKACG gene.

Elastin microfibril interfacer 1 (EMILIN-1) is a protein that in humans is encoded by the EMILIN1 gene. It is the best characterized member of the EMILIN family of extracellular matrix glycoproteins.

Transportin-3 is a protein that in humans is encoded by the TNPO3 gene.

40S ribosomal protein S7 is a protein that in humans is encoded by the RPS7 gene.

Transcriptional activator protein Pur-beta is a protein that in humans is encoded by the PURB gene.

Importin-13 is a protein encoded by the IPO13 gene in humans. Importin-13 is a member of the importin-β family of nuclear transport receptors (NTRs) and was first identified as a transport receptor in 2000. According to PSI-blast based secondary structure PREDiction (PSIPRED), importin-13 contains 38 α-helices. Importin-13 accommodates a range of cargoes due to its flexible superhelical structure and a cargo binding and release system that is distinct from other importin-like transport receptors. IPO13 is broadly expressed in a variety of tissues in the human body, including the heart, cornea, fetal lung, brain, endometrial carcinoma, and testes.

Importin 8 is a protein that in humans is encoded by the IPO8 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000205339 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000066232 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Gorlich D, Dabrowski M, Bischoff FR, Kutay U, Bork P, Hartmann E, Prehn S, Izaurralde E (Aug 1997). "A novel class of RanGTP binding proteins". J Cell Biol. 138 (1): 65–80. doi:10.1083/jcb.138.1.65. PMC 2139951 . PMID 9214382.
1 2 "Entrez Gene: IPO7 importin 7".

Jäkel S, Görlich D (1998). "Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells". EMBO J. 17 (15): 4491–4502. doi:10.1093/emboj/17.15.4491. PMC 1170780 . PMID 9687515.
Paraskeva E, Izaurralde E, Bischoff FR, et al. (1999). "CRM1-mediated recycling of snurportin 1 to the cytoplasm". J. Cell Biol. 145 (2): 255–264. doi:10.1083/jcb.145.2.255. PMC 2133107 . PMID 10209022.{{cite journal}}: CS1 maint: overridden setting (link)
Jäkel S, Albig W, Kutay U, et al. (1999). "The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1". EMBO J. 18 (9): 2411–2423. doi:10.1093/emboj/18.9.2411. PMC 1171324 . PMID 10228156.{{cite journal}}: CS1 maint: overridden setting (link)
Dean KA, von Ahsen O, Görlich D, Fried HM (2001). "Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin". J. Cell Sci. 114 (Pt 19): 3479–85. doi:10.1242/jcs.114.19.3479. hdl: 11858/00-001M-0000-0015-3D81-6 . PMID 11682607.
Bäuerle M, Doenecke D, Albig W (2002). "The requirement of H1 histones for a heterodimeric nuclear import receptor". J. Biol. Chem. 277 (36): 32480–32489. doi: 10.1074/jbc.M202765200 . PMID 12080050.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.{{cite journal}}: CS1 maint: overridden setting (link)
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–569. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.{{cite journal}}: CS1 maint: overridden setting (link)
Fassati A, Görlich D, Harrison I, et al. (2003). "Nuclear import of HIV-1 intracellular reverse transcription complexes is mediated by importin 7". EMBO J. 22 (14): 3675–3685. doi:10.1093/emboj/cdg357. PMC 165627 . PMID 12853482.{{cite journal}}: CS1 maint: overridden setting (link)
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.{{cite journal}}: CS1 maint: overridden setting (link)
King FW, Shtivelman E (2004). "Inhibition of nuclear import by the proapoptotic protein CC3". Mol. Cell. Biol. 24 (16): 7091–7101. doi:10.1128/MCB.24.16.7091-7101.2004. PMC 479715 . PMID 15282309.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.{{cite journal}}: CS1 maint: overridden setting (link)
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.{{cite journal}}: CS1 maint: overridden setting (link)
Kahle J, Baake M, Doenecke D, Albig W (2005). "Subunits of the heterotrimeric transcription factor NF-Y are imported into the nucleus by distinct pathways involving importin beta and importin 13". Mol. Cell. Biol. 25 (13): 5339–5354. doi:10.1128/MCB.25.13.5339-5354.2005. PMC 1157003 . PMID 15964792.
Arnold M, Nath A, Hauber J, Kehlenbach RH (2006). "Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1". J. Biol. Chem. 281 (30): 20883–20890. doi: 10.1074/jbc.M602189200 . PMID 16704975.
Zaitseva L, Myers R, Fassati A (2007). "tRNAs promote nuclear import of HIV-1 intracellular reverse transcription complexes". PLOS Biol. 4 (10): e332. doi: 10.1371/journal.pbio.0040332 . PMC 1584419 . PMID 17020411.
Saijou E, Itoh T, Kim KW, et al. (2007). "Nucleocytoplasmic shuttling of the zinc finger protein EZI Is mediated by importin-7-dependent nuclear import and CRM1-independent export mechanisms". J. Biol. Chem. 282 (44): 32327–32337. doi: 10.1074/jbc.M706793200 . PMID 17848547.{{cite journal}}: CS1 maint: overridden setting (link)

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000205339 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000066232 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9214382-5] Gorlich D, Dabrowski M, Bischoff FR, Kutay U, Bork P, Hartmann E, Prehn S, Izaurralde E (Aug 1997). "A novel class of RanGTP binding proteins". J Cell Biol. 138 (1): 65–80. doi:10.1083/jcb.138.1.65. PMC 2139951 . PMID 9214382.

[entrez-6] 1 2 "Entrez Gene: IPO7 importin 7".

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IPO7

Related Research Articles

References

Further reading