ITGB1BP3

Last updated
NMRK2
Identifiers
Aliases NMRK2 , ITGB1BP3, MIBP, NRK2, nicotinamide riboside kinase 2
External IDs OMIM: 608705 MGI: 1916814 HomoloGene: 113783 GeneCards: NMRK2
EC number 2.7.1.173
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_027120

RefSeq (protein)

NP_001276046
NP_733778
NP_001362396
NP_001362397
NP_001362398

Contents

NP_081396

Location (UCSC) Chr 19: 3.93 – 3.94 Mb Chr 10: 81.2 – 81.2 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Nicotinamide riboside kinase 2 is an enzyme that in humans is encoded by the ITGB1BP3 gene. [5] [6] [7]


Interactions

ITGB1BP3 has been shown to interact with ST7. [8]

Related Research Articles

Low-density lipoprotein receptor-related protein 8

Low-density lipoprotein receptor-related protein 8 (LRP8), also known as apolipoprotein E receptor 2 (ApoER2), is a protein that in humans is encoded by the LRP8 gene. ApoER2 is a cell surface receptor that is part of the low-density lipoprotein receptor family. These receptors function in signal transduction and endocytosis of specific ligands. Through interactions with one of its ligands, reelin, ApoER2 plays an important role in embryonic neuronal migration and postnatal long-term potentiation. Another LDL family receptor, VLDLR, also interacts with reelin, and together these two receptors influence brain development and function. Decreased expression of ApoER2 is associated with certain neurological diseases.

Integrin beta 2

In molecular biology, CD18 is an integrin beta chain protein that is encoded by the ITGB2 gene in humans. Upon binding with one of a number of alpha chains, CD18 is capable of forming multiple heterodimers, which play significant roles in cellular adhesion and cell surface signaling, as well as important roles in immune responses. CD18 also exists in soluble, ligand binding forms. Deficiencies in CD18 expression can lead to adhesion defects in circulating white blood cells in humans, reducing the immune system's ability to fight off foreign invaders.

Integrin beta 1

Integrin beta-1 (ITGB1), also known as CD29, is a cell surface receptor that in humans is encoded by the ITGB1 gene. This integrin associates with integrin alpha 1 and integrin alpha 2 to form integrin complexes which function as collagen receptors. It also forms dimers with integrin alpha 3 to form integrin receptors for netrin 1 and reelin. These and other integrin beta 1 complexes have been historically known as very late activation (VLA) antigens.

Integrin beta 3

Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ITGB3 gene. CD61 is a cluster of differentiation found on thrombocytes.

LRP1

Low density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER) or cluster of differentiation 91 (CD91), is a protein forming a receptor found in the plasma membrane of cells involved in receptor-mediated endocytosis. In humans, the LRP1 protein is encoded by the LRP1 gene. LRP1 is also a key signalling protein and, thus, involved in various biological processes, such as lipoprotein metabolism and cell motility, and diseases, such as neurodegenerative diseases, atherosclerosis, and cancer.

Integrin beta 4

Integrin, beta 4 (ITGB4) also known as CD104, is a human gene.

Integrin beta 5

Integrin beta-5 is a protein that in humans is encoded by the ITGB5 gene.

Integrin beta 7

Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene. It can pair with ITGA4 (CD49d) to form the heterodimeric integrin receptor α4β7, or with ITGAE (CD103) to form αEβ7.

CIB1

Calcium and integrin-binding protein 1 is a protein that in humans is encoded by the CIB1 gene.

LRP6

Low-density lipoprotein receptor-related protein 6 is a protein that in humans is encoded by the LRP6 gene. LRP6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway.

EIF6

Eukaryotic translation initiation factor 6 (EIF6), also known as Integrin beta 4 binding protein (ITGB4BP), is a human gene.

ST7

Suppressor of tumorigenicity protein 7 is a protein that in humans is encoded by the ST7 gene. ST7 orthologs have been identified in all mammals for which complete genome data are available.

ITGB1BP1

Integrin beta-1-binding protein 1 is a protein that in humans is encoded by the ITGB1BP1 gene.

ITGB3BP

Centromere protein R is a protein that in humans is encoded by the ITGB3BP gene.

MAPK8IP2

C-jun-amino-terminal kinase-interacting protein 2 is a protein or the name of the gene that encodes it. The gene is also known as Islet-Brain-2 (IB2).

Integrin beta 8

Integrin beta-8 is a protein that in humans is encoded by the ITGB8 gene.

APBB2

Amyloid beta A4 precursor protein-binding family B member 2 is a protein that in humans is encoded by the APBB2 gene.

TENC1

Tensin-like C1 domain-containing phosphatase is an enzyme that in humans is encoded by the TENC1 gene.

SYNJ2BP

Synaptojanin-2-binding protein is a protein that in humans is encoded by the SYNJ2BP gene.

LRP3

Low density lipoprotein receptor-related protein 3 (LRP-3) is a protein that in humans is encoded by the LRP3 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000077009 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004939 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Li J, Mayne R, Wu C (Feb 2000). "A novel muscle-specific beta 1 integrin binding protein (MIBP) that modulates myogenic differentiation". J Cell Biol. 147 (7): 1391–8. doi:10.1083/jcb.147.7.1391. PMC   2174245 . PMID   10613898.
  6. Bieganowski P, Brenner C (May 2004). "Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans". Cell. 117 (4): 495–502. doi: 10.1016/S0092-8674(04)00416-7 . PMID   15137942. S2CID   4642295.
  7. "Entrez Gene: ITGB1BP3 integrin beta 1 binding protein 3".
  8. Battle, Michele A; Maher Veronica M; McCormick J Justin (Jun 2003). "ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways". Biochemistry. United States. 42 (24): 7270–82. doi:10.1021/bi034081y. ISSN   0006-2960. PMID   12809483.

Further reading