| ST7 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | ST7 , ETS7q, FAM4A, FAM4A1, HELG, RAY1, SEN4, TSG7, suppression of tumorigenicity 7 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 600833 MGI: 1927450 HomoloGene: 10185 GeneCards: ST7 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Suppressor of tumorigenicity protein 7 is a protein that in humans is encoded by the ST7 gene. [5] [6] [7] ST7 orthologs [8] have been identified in all mammals for which complete genome data are available.
The gene for this product maps to a region on human chromosome 7 identified as an autism-susceptibility locus. Mutation screening of the entire coding region in autistic individuals failed to identify phenotype-specific variants, suggesting that coding mutations for this gene are unlikely to be involved in the etiology of autism. The function of this gene product has not been determined. Transcript variants encoding different isoforms of this protein have been described. [7]
ST7 has been shown to interact with ITGB1BP3 [9] and GNB2L1. [9]
Phosphatase and tensin homolog (PTEN) is a phosphatase in humans and is encoded by the PTEN gene. Mutations of this gene are a step in the development of many cancers, specifically glioblastoma, lung cancer, breast cancer, and prostate cancer. Genes corresponding to PTEN (orthologs) have been identified in most mammals for which complete genome data are available.
p16, is a protein that slows cell division by slowing the progression of the cell cycle from the G1 phase to the S phase, thereby acting as a tumor suppressor. It is encoded by the CDKN2A gene. A deletion in this gene can result in insufficient or non-functional p16, accelerating the cell cycle and resulting in many types of cancer.
Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog , also known as CDC73 and parafibromin, is a protein which in humans is encoded by the CDC73 gene.
Band 4.1-like protein 3 is a protein that in humans is encoded by the EPB41L3 gene.
Inhibitor of growth protein 1 is a protein that in humans is encoded by the ING1 gene.
Cell adhesion molecule 1 is a protein that, in humans, is encoded by the CADM1 gene.
The CYLD lysine 63 deubiquitinase gene, also termed the CYLD gene, CYLD is an evolutionary ancient gene found to be present as far back on the evolutionary scale as in sponges. In humans, this gene is located in band 12.1 on the long arm of chromosome 16 and is known to code multiple proteins through the process of alternative splicing.
CDKN2A, also known as cyclin-dependent kinase inhibitor 2A, is a gene which in humans is located at chromosome 9, band p21.3. It is ubiquitously expressed in many tissues and cell types. The gene codes for two proteins, including the INK4 family member p16 and p14arf. Both act as tumor suppressors by regulating the cell cycle. p16 inhibits cyclin dependent kinases 4 and 6 and thereby activates the retinoblastoma (Rb) family of proteins, which block traversal from G1 to S-phase. p14ARF activates the p53 tumor suppressor. Somatic mutations of CDKN2A are common in the majority of human cancers, with estimates that CDKN2A is the second most commonly inactivated gene in cancer after p53. Germline mutations of CDKN2A are associated with familial melanoma, glioblastoma and pancreatic cancer. The CDKN2A gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.
Ubiquitin-associated protein 1 is a protein that in humans is encoded by the UBAP1 gene.
Protein polybromo-1 (PB1) also known as BRG1-associated factor 180 (BAF180) is a protein that in humans is encoded by the PBRM1 gene.
Apoptosis facilitator Bcl-2-like protein 14 is a protein that in humans is encoded by the BCL2L14 gene.
BRCA1 associated protein-1 is a deubiquitinating enzyme that in humans is encoded by the BAP1 gene. BAP1 encodes an 80.4 kDa nuclear-localizing protein with a ubiquitin carboxy-terminal hydrolase (UCH) domain that gives BAP1 its deubiquitinase activity. Recent studies have shown that BAP1 and its fruit fly homolog, Calypso, are members of the polycomb-group proteins (PcG) of highly conserved transcriptional repressors required for long-term silencing of genes that regulate cell fate determination, stem cell pluripotency, and other developmental processes.
Caveolin-2 is a protein that in humans is encoded by the CAV2 gene.
Transmembrane protein 158 is a protein that in humans is encoded by the TMEM158 gene.
Deleted in esophageal cancer 1 is a protein that in humans is encoded by the DEC1 gene.
Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 is a protein that in humans is encoded by the ASZ1 gene.
In molecular biology, ST7 antisense RNA 2, also known as ST7-AS2 is a long non-coding RNA. In humans, it is found on chromosome 7 in a locus spanning a translocation breakpoint associated with autism. It is antisense to the ST7 gene.
In molecular biology, ST7 overlapping transcript 3, also known as ST7-OT3 is a long non-coding RNA. In humans, it is found on chromosome 7 in a locus spanning a translocation breakpoint associated with autism. It overlaps the ST7 gene, spanning intron 10 to exon 14 of ST7. Some isoforms of ST7 may use exons from ST7-OT3.
In molecular biology, ST7 overlapping transcript 4, also known as ST7-OT4 is a long non-coding RNA. In humans, it is found on chromosome 7 in a locus spanning a translocation breakpoint associated with autism. It contains at least 7 exons and overlaps the ST7 gene.
Patched 2 is a protein that in humans is encoded by the PTCH2 gene.
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