ITGB3BP

ITGB3BP
Identifiers
Aliases	ITGB3BP , CENP-R, CENPR, HSU37139, NRIF3, TAP20, integrin subunit beta 3 binding protein
External IDs	OMIM: 605494; MGI: 1914983; HomoloGene: 8617; GeneCards: ITGB3BP; OMA:ITGB3BP - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p31.3 Start 63,440,770 bp [1] End 63,593,721 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 C6 Start 99,653,639 bp [2] End 99,787,010 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte Achilles tendon secondary oocyte testicle right uterine tube ventricular zone sperm ganglionic eminence gonad right testis Top expressed in testicle spermatocyte ventricular zone spermatid quadriceps femoris muscle epiblast embryo proximal tubule right kidney neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity protein C-terminus binding protein binding Cellular component cytoplasm cytosol membrane nucleoplasm chromosome chromosome, centromeric region nucleus kinetochore Biological process regulation of transcription, DNA-templated CENP-A containing chromatin assembly transcription, DNA-templated cell division cell adhesion positive regulation of apoptotic process cell cycle signal transduction apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23421 67733 Ensembl ENSG00000142856 ENSMUSG00000028549 UniProt Q13352 Q9CQ82 RefSeq (mRNA) NM_001206739 NM_014288 NM_001347145 NM_001347147 NM_001347148 NM_026348 NM_001362974 NM_001362975 NM_001362976 RefSeq (protein) NP_001193668 NP_001334074 NP_001334076 NP_001334077 NP_055103 NP_080624 NP_001349903 NP_001349904 NP_001349905 Location (UCSC) Chr 1: 63.44 – 63.59 Mb Chr 4: 99.65 – 99.79 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Centromere protein R is a protein that in humans is encoded by the ITGB3BP gene. ^{[5] [6] [7]}

Interactions

ITGB3BP has been shown to interact with:

• CD61, ^{[5] [8]}
• Cyclin A2, ^[9]
• NFKB1, ^[10]
• RXRA, ^[6]
• RXRG, ^[11] and
• THRA. ^{[6] [11]}

References

1. GRCh38: Ensembl release 89: ENSG00000142856 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028549 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shattil SJ, O'Toole T, Eigenthaler M, Thon V, Williams M, Babior BM, Ginsberg MH (December 1995). "Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit". J Cell Biol. 131 (3): 807–16. doi:10.1083/jcb.131.3.807. PMC   2120613 . PMID   7593198.
6. Li D, Desai-Yajnik V, Lo E, Schapira M, Abagyan R, Samuels HH (February 2000). "NRIF3 is a novel coactivator mediating functional specificity of nuclear hormone receptors". Mol Cell Biol. 19 (10): 7191–202. doi:10.1128/mcb.19.10.7191. PMC   84712 . PMID   10490654.
7. "Entrez Gene: ITGB3BP integrin beta 3 binding protein (beta3-endonexin)".
8. Fujimoto TT, Katsutani S, Shimomura T, Fujimura K (January 2002). "Novel alternatively spliced form of beta(3)-endonexin". Thromb. Res. 105 (1): 63–70. doi:10.1016/s0049-3848(01)00405-4. PMID   11864709.
9. Ohtoshi A, Maeda T, Higashi H, Ashizawa S, Yamada M, Hatakeyama M (January 2000). "beta3-endonexin as a novel inhibitor of cyclin A-associated kinase". Biochem. Biophys. Res. Commun. 267 (3): 947–52. doi:10.1006/bbrc.1999.2007. PMID   10673397.
10. Besta F, Massberg S, Brand K, Müller E, Page S, Grüner S, Lorenz M, Sadoul K, Kolanus W, Lengyel E, Gawaz M (October 2002). "Role of beta(3)-endonexin in the regulation of NF-kappaB-dependent expression of urokinase-type plasminogen activator receptor". J. Cell Sci. 115 (Pt 20): 3879–88. doi: 10.1242/jcs.00081 . PMID   12244126.
11. Li D, Wang F, Samuels HH (December 2001). "Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation". Mol. Cell. Biol. 21 (24): 8371–84. doi:10.1128/MCB.21.24.8371-8384.2001. PMC   100002 . PMID   11713274.

Further reading

• Kashiwagi H, Schwartz MA, Eigenthaler M, Davis KA, Ginsberg MH, Shattil SJ (1997). "Affinity modulation of platelet integrin alphaIIbbeta3 by beta3-endonexin, a selective binding partner of the beta3 integrin cytoplasmic tail". J. Cell Biol. 137 (6): 1433–43. doi:10.1083/jcb.137.6.1433. PMC   2132534 . PMID   9182673.
• Tang S, Gao Y, Ware JA (1999). "Enhancement of endothelial cell migration and in vitro tube formation by TAP20, a novel beta 5 integrin-modulating, PKC theta-dependent protein". J. Cell Biol. 147 (5): 1073–84. doi:10.1083/jcb.147.5.1073. PMC   2169340 . PMID   10579726.
• Ohtoshi A, Maeda T, Higashi H, Ashizawa S, Yamada M, Hatakeyama M (2000). "beta3-endonexin as a novel inhibitor of cyclin A-associated kinase". Biochem. Biophys. Res. Commun. 267 (3): 947–52. doi:10.1006/bbrc.1999.2007. PMID   10673397.
• Li D, Wang F, Samuels HH (2001). "Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation". Mol. Cell. Biol. 21 (24): 8371–84. doi:10.1128/MCB.21.24.8371-8384.2001. PMC   100002 . PMID   11713274.
• Fujimoto TT, Katsutani S, Shimomura T, Fujimura K (2002). "Novel alternatively spliced form of beta(3)-endonexin". Thromb. Res. 105 (1): 63–70. doi:10.1016/S0049-3848(01)00405-4. PMID   11864709.
• Besta F, Massberg S, Brand K, Müller E, Page S, Grüner S, Lorenz M, Sadoul K, Kolanus W, Lengyel E, Gawaz M (2003). "Role of beta(3)-endonexin in the regulation of NF-kappaB-dependent expression of urokinase-type plasminogen activator receptor". J. Cell Sci. 115 (Pt 20): 3879–88. doi: 10.1242/jcs.00081 . PMID   12244126.
• Li D, Das S, Yamada T, Samuels HH (2004). "The NRIF3 family of transcriptional coregulators induces rapid and profound apoptosis in breast cancer cells". Mol. Cell. Biol. 24 (9): 3838–48. doi:10.1128/MCB.24.9.3838-3848.2004. PMC   387764 . PMID   15082778.
• Talukder AH, Gururaj A, Mishra SK, Vadlamudi RK, Kumar R (2004). "Metastasis-associated protein 1 interacts with NRIF3, an estrogen-inducible nuclear receptor coregulator". Mol. Cell. Biol. 24 (15): 6581–91. doi:10.1128/MCB.24.15.6581-6591.2004. PMC   444867 . PMID   15254226.
• Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW (2006). "The human CENP-A centromeric nucleosome-associated complex". Nat. Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID   16622419. S2CID   205286556.
• Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T (2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nat. Cell Biol. 8 (5): 446–57. doi:10.1038/ncb1396. PMID   16622420. S2CID   26974412.