James (Jim) Woodgett | |
---|---|
Born | 9 February 1960 Leicestershire, England |
Occupation(s) | Research Institute Director (2005-21) and Principal Investigator |
Known for | co-discoveries of the molecules PKB/Akt and SAPK/JNKs, and the functions of the GSK-3 genes. |
Spouse | Caroline |
Awards | Fellow of the Royal Society of Canada |
Academic background | |
Education | BSc University of York, PhD University of Dundee |
Doctoral advisor | Sir Philip Cohen |
Other advisors | Tony Hunter, Salk Institute |
Influences | Louis Siminovitch |
Academic work | |
Discipline | Molecular Biology |
Sub-discipline | Molecular Biology |
Institutions | Lunenfeld-Tanenbaum Research Institute,Mount Sinai Hospital,Toronto |
Notable ideas | Characterization of the biological role of protein kinases including GSK-3,protein kinase B/Akt and stress-activated protein kinases |
Website | https://www.lunenfeld.ca/ |
James (Jim) Woodgett is a British-born biologist and the Principal Investigator of an active research laboratory at the Lunenfeld-Tanenbaum Research Institute,Sinai Health System (formerly Mount Sinai Hospital),in Toronto,Ontario,Canada. [1] [2] He was the Koffler Director of Research at the Lunenfeld-Tanenbaum Research Institute from November 2005 to January 2021. [3]
Woodgett's research spans the fields of Signal Transduction,Cancer Stem Cells,Diabetes,and Neurological Disorders. [4] He is known for his co-discoveries of the molecules PKB/Akt and SAPK/JNKs,which have central roles in the evolution of cancer. [5] Woodgett is also an authority on the functions of the GSK-3 genes,which play significant roles in insulin/diabetes and brain development/Alzheimer's disease,as well as bipolar disorder. [5]
Woodgett is a long-time advocate for increasing public support for science and medical research. [6] [1] [7] [8] He is known for his science communication [9] and public science outreach, [2] [10] [11] as well as his support for Women in STEM [12] and early career researchers. [1]
Woodgett is frequently interviewed by journalists to provide commentary on questions of research relating to health matters,and also medical and science research funding and policy. [1] [13] [14] [15] [16]
Jim Woodgett was born in Leicestershire in the United Kingdom,He grew up in the village of Quorn. [1] Encouraged by his mother,he entered the BBC's Inventor of the Year competition and won a runner-up prize. [1]
Woodgett studied biochemistry as an undergraduate at the University of York,before undertaking doctoral research at the University of Dundee,Scotland. [1] [17] He did post-doctoral research in Tony Hunter's group at the Salk Institute for Biological Studies in California. [1] This was followed by five years (1987-1992) at the Ludwig Institute for Cancer Research in Middlesex,England,where he headed his own research laboratory. [1]
In 1992,Woodgett and his family emigrated to Canada from the United Kingdom. He worked at the Ontario Cancer Institute,based at Princess Margaret Hospital. His fellow researchers at the time included Tak Mak and Josef Penninger. [5] [1] [18] Woodgett went on to be appointed head of the division of experimental therapeutics,and director of the Microarray Centre at University Health Network. [1]
In 2005,Woodgett became Director of the Lunenfeld-Tanenbaum Research Institute. He is also a professor of medical biophysics at the University of Toronto. [19]
Jim Woodgett has (co-)authored over 300 peer-reviewed scientific research articles. [4] In 2007,he was interviewed for the Question and Answer section of the journal Current Biology ,about his research and thoughts on being a scientist. [17]
Woodgett is a Member of the Medical Advisory Board of the Gairdner Foundation. [5]
When the CIHR proposed to change the way that it awarded research grants,including replacing the existing face-to-face peer reviews of grant applications with a virtual,anonymous review system,Woodgett wrote an open letter to Federal Health Minister Jane Philpott criticizing the changes. [20] Within days more than 1,300 scientists and researchers had signed on to his letter. Woodgett subsequently met with Minister Philpott on July 13,2016. [21] While some plans were re-evaluated,Woodgett later told University Affairs magazine that with the next round of research applications looming,the CIHR grant system "is still a mess." [7]
Together with Professor Imogen Coe,the founding Dean of Science at Ryerson University,Woodgett co-organized a one-day conference,held at the end of May 2017 in Toronto,at which researchers came together to discuss,and to support [22] the findings of the Naylor Report:Investing in Canada's Future –Strengthening the Foundations of Canadian Research. [23] [24] [25] [26]
In June 2016,Dr. Kirsty Duncan,then Minister of Science in the Liberal government of Prime Minister Justin Trudeau,commissioned a nine-member advisory panel,chaired by former president of the University of Toronto,Dr. David Naylor,to consult with Canada's research community and to report on the state of basic science and scholarly inquiry in Canada. [23]
2000 –Elected Fellow of the Royal Society of Canada in the field of Molecular Biology and Genetics [27]
2018 –Awarded the Arthur Wynne Gold Medal by the Canadian Society for Molecular Biosciences [28]
Mount Sinai Hospital (MSH) is a hospital in Toronto,Ontario,Canada. Mount Sinai is part of Sinai Health. Sinai Health was formed through the voluntary amalgamation of Mount Sinai Hospital and Hennick Bridgepoint Hospital on January 22,2015.
Louis Siminovitch was a Canadian molecular biologist. He was a pioneer in human genetics,researcher into the genetic basis of muscular dystrophy and cystic fibrosis,and helped establish Ontario programs exploring genetic roots of cancer.
The Gairdner Foundation is a non-profit organization devoted to the recognition of outstanding achievements in biomedical research worldwide. It was created in 1957 by James Arthur Gairdner to recognize and reward the achievements of medical researchers whose work contributes significantly to improving the quality of human life. Since the first awards were made in 1959,the Gairdner Awards have become Canada's most prestigious medical awards,recognizing and celebrating the research of the world’s best and brightest biomedical researchers. Since 1959,more than 390 Canada Gairdner Awards have been given to scientists from 35 countries;of these recipients,98 have subsequently gone on to win a Nobel Prize.
Christopher David Naylor,is a Canadian physician,medical researcher and former president of the University of Toronto. He is ICES scientist emeritus and founding CEO. In 2016,he was inducted into the Canadian Medical Hall of Fame.
The Canadian Institutes of Health Research is a federal agency responsible for funding health and medical research in Canada. Comprising 13 institutes,it is the successor to the Medical Research Council of Canada.
Lawrence M. Tanenbaum is a Canadian businessman and chairman of Maple Leaf Sports &Entertainment (MLSE). He owns a 25% stake in MLSE through his holding company Kilmer Sports Inc.
The Lunenfeld-Tanenbaum Research Institute is a medical research institute in Toronto,Ontario and part of the Sinai Health System. It was originally established in 1985 as the Samuel Lunenfeld Research Institute,the research arm of Mount Sinai Hospital,by an endowment from the Lunenfeld and Kunin families. It was renamed to the current name on June 24,2013,after a $35 million donation from Larry and Judy Tanenbaum.
The Stem Cell Network (SCN) is a Canadian non-profit that supports stem cell and regenerative medicine research,teaches the next generation of highly qualified personal,and delivers outreach activities across Canada. The Network has been supported by the Government of Canada,since inception in 2001. SCN has catalyzed 25 clinical trials,21 start-up companies,incubated several international and Canadian research networks and organizations,and established the Till &McCulloch Meetings,Canada's foremost stem cell research event.
Alan Bernstein is Professor Emeritus at the University of Toronto and President Emeritus of CIFAR,where he served as President and CEO from 2012 to 2022. A Distinguished Fellow at the Munk School of Global Affairs and Public Policy,he is also a Fellow and Member of the Standing Committee for Science Planning at the International Science Council (2022-2025). Bernstein is recognized as a leader in health research,science policy,mentorship and organizational leadership.
Michael R. Hayden,is a Killam Professor of Medical Genetics at the University of British Columbia,the highest honour UBC can confer on any faculty member. Only four such awards have ever been conferred in the Faculty of Medicine. Dr. Hayden is also Canada Research Chair in Human Genetics and Molecular Medicine. Hayden is best known for his research in Huntington disease (HD).
Graham Leon Collingridge is a British neuroscientist and professor at the University of Toronto and at the University of Bristol. He is also a senior investigator at the Lunenfeld-Tanenbaum Research Institute,Mount Sinai Hospital in Toronto.
Andras Nagy is a research scientist at the Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital in Toronto,Ontario. He heads a team of 50 researchers on Project Grandiose,who study the process of creating stem cells. Nagy holds a Canadian Research Chair in stem cells and regeneration.
Daniel Joshua Drucker is a Canadian endocrinologist. A Fellow of the Royal Society,he is a professor of medicine at the Lunenfeld-Tanenbaum Research Institute,Mount Sinai Hospital,Toronto. He is known for his research into intestinal hormones and their use in the treatment of diabetes,obesity,and other metabolic diseases,as well as intestinal failure.
The Sinai Health System is a hospital system which serves Toronto,Ontario,Canada. It comprises two hospitals,Mount Sinai Hospital and Hennick Bridgepoint Hospital,both affiliated with the University of Toronto Faculty of Medicine.
The Global Alliance for Genomics and Health (GA4GH) is an international consortium that is developing standards for responsibly collecting,storing,analyzing,and sharing genomic data in order to enable an "internet of genomics". GA4GH was founded in 2013.
Anne-Claude Gingras is a senior investigator at Lunenfeld-Tanenbaum Research Institute,and a professor in the department of molecular genetics at the University of Toronto. She is an expert in mass spectrometry based proteomics technology that allows identification and quantification of protein from various biological samples.
Allison Joan McGeer is a Canadian infectious disease specialist in the Sinai Health System,and a professor in the Department of Laboratory Medicine and Pathobiology at the University of Toronto. She also appointed at the Dalla Lana School of Public Health and a Senior Clinician Scientist at the Lunenfeld-Tanenbaum Research Institute,and is a partner of the National Collaborating Centre for Infectious Diseases. McGeer has led investigations into the severe acute respiratory syndrome outbreak in Toronto and worked alongside Donald Low. During the COVID-19 pandemic,McGeer has studied how SARS-CoV-2 survives in the air and has served on several provincial committees advising aspects of the Government of Ontario's pandemic response.
Cindy-Lee E. Dennis is a Canadian professor in the Lawrence Bloomberg Faculty of Nursing and the Faculty of Medicine,Department of Psychiatry at the University of Toronto. She is also a senior scientist at the Lunenfeld-Tannenbaum Research Institute at Mt Sinai Hospital in Toronto. She previously held the Women's Health Research Chair at Li Ka Shing Knowledge Institute,St. Michael's Hospital,the Canada Research Chair in Perinatal Community Health at the University of Toronto,and the Shirley Brown Chair in Women's Mental Health at Women's College Hospital.
Jeffrey L. Wrana is a Canadian cancer researcher. He is the CIBC Breast Cancer Research Scientist and Mary Janigan Research Chair in Molecular Cancer Therapeutic at Mount Sinai Hospital and University of Toronto. As a Tier 1 Canada Research Chair in Medical Genetics and Microbiology at U of T,Wrana was elected a Fellow of the Royal Society of Canada.
Ken Croitoru is a Canadian gastroenterologist who works at Mount Sinai Hospital in Toronto,a scientist at the Lunenfeld-Tanenbaum Research Institute,and a professor in the Department of Medicine at the University of Toronto. He is best known for his leadership of the Genetic,Environmental,Microbial (GEM) Project,a comprehensive research initiative aiming to understand the triggers of Crohn's disease.