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Indiana vesiculovirus,formerly Vesicular stomatitis Indiana virus is a virus in the family Rhabdoviridae;the well-known Rabies lyssavirus belongs to the same family. VSIV can infect insects,cattle,horses and pigs. It has particular importance to farmers in certain regions of the world where it infects cattle. This is because its clinical presentation is identical to the very important foot and mouth disease virus.
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Herpesviridae is a large family of DNA viruses that cause infections and certain diseases in animals,including humans. The members of this family are also known as herpesviruses. The family name is derived from the Greek word ἕρπειν,referring to spreading cutaneous lesions,usually involving blisters,seen in flares of herpes simplex 1,herpes simplex 2 and herpes zoster (shingles). In 1971,the International Committee on the Taxonomy of Viruses (ICTV) established Herpesvirus as a genus with 23 viruses among four groups. As of 2020,115 species are recognized,all but one of which are in one of the three subfamilies. Herpesviruses can cause both latent and lytic infections.
Human Herpes Virus (HHV) Infected Cell Polypeptide 0 (ICP0) is a protein,encoded by the DNA of herpes viruses. It is produced by herpes viruses during the earliest stage of infection,when the virus has recently entered the host cell;this stage is known as the immediate-early or α ("alpha") phase of viral gene expression. During these early stages of infection,ICP0 protein is synthesized and transported to the nucleus of the infected host cell. Here,ICP0 promotes transcription from viral genes,disrupts structures in the nucleus known as nuclear dots or promyelocytic leukemia (PML) nuclear bodies,and alters the expression of host and viral genes in combination with a neuron specific protein. At later stages of cellular infection,ICP0 relocates to the cell cytoplasm to be incorporated into new virion particles.
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Sarah A. Connolly is an American virologist. She graduated with a PhD from the University of Pennsylvania in 2003 and is notable for her work on Paramyxovirus and Herpes virus.
Herpesvirus glycoprotein B is a viral glycoprotein that is involved in the viral cell entry of Herpes simplex virus (HSV). Herpesviruses have a lipid bilayer,called the envelope,which contains twelve surface glycoproteins. For infectivity to be attained,the double stranded DNA genome of HSV must enter the host cell through means of fusion of its envelope with the cellular membrane or via endocytosis. Other viral glycoproteins involved in the process of viral cell entry include gC,gB,gD,gH,and gL,but only gC,gB,gD,and gH are required for the fusion of the HSV's envelope with the cellular membrane. It can be noted that all herpesviruses have glycoproteins gB,gH,and gL.
David Mahan Knipe is the Higgins Professor of Microbiology and Molecular Genetics in the Department of Microbiology at the Harvard Medical School in Boston,Massachusetts and co-chief editor of the reference book Fields Virology. He returned to the Chair of the Program in Virology at Harvard Medical School in 2019,having previously held the position from 2004 through 2016 and served as interim Co-Chair of the Microbiology and Immunobiology Department from 2016 through 2018.
Roselyn J. Eisenberg is a professor at The University of Pennsylvania and a member of the University's School of Veterinary Medicine and School of Dental Medicine. The majority of Eisenberg's research is focused on the herpes simplex virus and the poxvirus and how they enter into susceptible cells. She also studies glycoproteins,vaccines,virology and microbiology.
Paired immunoglobin like type 2 receptor alpha is a protein that in humans is encoded by the PILRA gene.
Patricia Gail Spear is an American virologist. She is a professor emeritus of microbiology and immunology at Northwestern University in Evanston,Illinois. She is best known for her pioneering work studying the herpes simplex virus. Spear is a past president of the American Society for Virology and an elected member of the National Academy of Sciences.
References
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- 1 2 Newcomb, William W.; Trus, Benes L.; Booy, Frank P.; Steven, Alasdair C.; Wall, Joseph S.; Brown, Jay C. (July 20, 1993). "Structure of the Herpes Simplex Virus Capsid Molecular Composition of the Pentons and the Triplexes". Journal of Molecular Biology. 232 (2): 499–511. doi:10.1006/jmbi.1993.1406. PMID 8393939 – via ScienceDirect.
- ↑ Baker, T. S.; Newcomb, W. W.; Olson, N. H.; Cowsert, L. M.; Olson, C.; Brown, J. C. (December 1, 1991). "Structures of bovine and human papillomaviruses. Analysis by cryoelectron microscopy and three-dimensional image reconstruction". Biophysical Journal. 60 (6): 1445–1456. Bibcode:1991BpJ....60.1445B. doi:10.1016/S0006-3495(91)82181-6. PMC 1260204 . PMID 1663794.
- ↑ Brown, Jay C. (February 13, 2021). "Role of Gene Length in Control of Human Gene Expression: Chromosome-Specific and Tissue-Specific Effects". International Journal of Genomics. 2021: e8902428. doi: 10.1155/2021/8902428 . PMC 7911607 . PMID 33688492.
- ↑ "av - Editorial Board". Hindawi.
- ↑ "Emeritus Faculty".
- ↑ Brown, Jay C. (September 12, 2019). "Control of human testis-specific gene expression". PLOS ONE. 14 (9): e0215184. Bibcode:2019PLoSO..1415184B. doi: 10.1371/journal.pone.0215184 . PMC 6742485 . PMID 31514204.
- ↑ "Jay C. Brown". scholar.google.com.
- ↑ Thach, R. E.; Sundararajan, T. A.; Dewey, K. F.; Brown, J. C.; Doty, Paul (January 1, 1966). "Translation of Synthetic Messenger RNA". Cold Spring Harbor Symposia on Quantitative Biology. 31: 85–97. doi:10.1101/SQB.1966.031.01.015. PMID 4295326 – via symposium.cshlp.org.
- ↑ Thach, R. E.; Dewey, K. F.; Brown, J. C.; Doty, Paul (July 22, 1966). "Formylmethionine Codon AUG as an Initiator of Polypeptide Synthesis". Science. 153 (3734): 416–418. Bibcode:1966Sci...153..416T. doi:10.1126/science.153.3734.416. PMID 5328567. S2CID 45022863.
- ↑ Brown, J. C.; Doty, P. (February 11, 1971). "Kinetic preference for initiation of protein synthesis at AUG codons". Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis. 228 (3): 746–748. doi:10.1016/0005-2787(71)90740-4. PMID 4929431 – via PubMed.
- ↑ Brown, J. C. (December 1, 1971). "Surface glycoprotein characteristic of the differentiated state of neuroblastoma C-1300 cells". Experimental Cell Research. 69 (2): 440–442. doi:10.1016/0014-4827(71)90247-3. PMID 5163635 – via ScienceDirect.
- ↑ Brown, J. C. (March 9, 1972). "Cell surface glycoproteins I: Accumulation of a glycoprotein on the outer surface of mouse LS cells during mitosis". Journal of Supramolecular Structure. 1 (1): 1–7. doi:10.1002/jss.400010102. PMID 4650442.
- ↑ Hunt, Richard C.; Brown, Jay C. (January 1, 1974). "Surface glycoproteins of mouse L cells". Biochemistry. 13 (1): 22–28. doi:10.1021/bi00698a004. PMID 4855553.
- ↑ Hunt, Richard C.; Gold, Elizabeth; Brown, Jay C. (December 16, 1975). "Cell cycle dependent exposure of a high molecular weight protein on the surface of mouse L cells". Biochimica et Biophysica Acta (BBA) - Biomembranes. 413 (3): 453–458. doi:10.1016/0005-2736(75)90128-5. PMID 1238124 – via ScienceDirect.
- ↑ "Role of Polycomb Repressive Complex 2 in Regulation of Human Transcription Factor Gene Expression" (PDF).
- ↑ Brown, Jay C. (January 27, 2023). "Backup transcription factor binding sites protect human genes from mutations in the promoter": 2023.01.27.525856. doi:10.1101/2023.01.27.525856. S2CID 256417694 – via bioRxiv.
{{cite journal}}: Cite journal requires|journal=(help) - ↑ Newcomb, W W; Brown, J C (July 9, 1981). "Role of the vesicular stomatitis virus matrix protein in maintaining the viral nucleocapsid in the condensed form found in native virions". Journal of Virology. 39 (1): 295–299. doi:10.1128/jvi.39.1.295-299.1981. PMC 171289 . PMID 6268817.
- ↑ Newcomb, W W; Tobin, G J; McGowan, J J; Brown, J C (March 9, 1982). "In vitro reassembly of vesicular stomatitis virus skeletons". Journal of Virology. 41 (3): 1055–1062. doi:10.1128/jvi.41.3.1055-1062.1982. PMC 256843 . PMID 6284961.
- ↑ Thomas, D; Newcomb, W W; Brown, J C; Wall, J S; Hainfeld, J F; Trus, B L; Steven, A C (May 9, 1985). "Mass and molecular composition of vesicular stomatitis virus: a scanning transmission electron microscopy analysis". Journal of Virology. 54 (2): 598–607. doi:10.1128/jvi.54.2.598-607.1985. PMC 254833 . PMID 2985822.
- ↑ Baker, T. S.; Newcomb, W. W.; Olson, N. H.; Cowsert, L. M.; Olson, C.; Brown, J. C. (December 9, 1991). "Structures of bovine and human papillomaviruses. Analysis by cryoelectron microscopy and three-dimensional image reconstruction". Biophysical Journal. 60 (6): 1445–1456. Bibcode:1991BpJ....60.1445B. doi:10.1016/S0006-3495(91)82181-6. PMC 1260204 . PMID 1663794.
- ↑ Newcomb, W. W.; Brown, J. C. (February 9, 1991). "Structure of the herpes simplex virus capsid: effects of extraction with guanidine hydrochloride and partial reconstitution of extracted capsids". Journal of Virology. 65 (2): 613–620. doi:10.1128/JVI.65.2.613-620.1991. PMC 239799 . PMID 1846187.
- ↑ Baker, T. S.; Newcomb, W. W.; Booy, F. P.; Brown, J. C.; Steven, A. C. (February 1990). "Three-dimensional structures of maturable and abortive capsids of equine herpesvirus 1 from cryoelectron microscopy | Journal of Virology". Journal of Virology. 64 (2): 563–573. doi:10.1128/jvi.64.2.563-573.1990. PMC 249145 . PMID 2153224.
- ↑ Newcomb, W. W.; Homa, F. L.; Thomsen, D. R.; Ye, Z.; Brown, J. C. (September 9, 1994). "Cell-free assembly of the herpes simplex virus capsid". Journal of Virology. 68 (9): 6059–6063. doi:10.1128/JVI.68.9.6059-6063.1994. PMC 237013 . PMID 8057482.
- ↑ Ww, Newcomb; Fl, Homa; Dr, Thomsen; Bl, Trus; N, Cheng; A, Steven; F, Booy; Jc, Brown (May 9, 1999). "Assembly of the herpes simplex virus procapsid from purified components and identification of small complexes containing the major capsid and scaffolding proteins". Journal of Virology. 73 (5): 4239–4250. doi:10.1128/JVI.73.5.4239-4250.1999. PMC 104203 . PMID 10196320.
- ↑ Heymann, J. Bernard; Cheng, Naiqian; Newcomb, William W.; Trus, Benes L.; Brown, Jay C.; Steven, Alasdair C. (May 9, 2003). "Dynamics of herpes simplex virus capsid maturation visualized by time-lapse cryo-electron microscopy". Nature Structural Biology. 10 (5): 334–341. doi:10.1038/nsb922. PMID 12704429. S2CID 21039842 – via PubMed.
- ↑ Trus, Benes L.; Booy, Frank P.; Newcomb, William W.; Brown, Jay C.; Homa, Fred L.; Thomsen, Darrell R.; Steven, Alasdair C. (November 1, 1996). "The herpes simplex virus procapsid: structure, conformational changes upon maturation, and roles of the triplex proteins VP19c and VP23 in assembly". Journal of Molecular Biology. 263 (3): 447–462. doi:10.1016/S0022-2836(96)80018-0. PMID 8918600 – via ScienceDirect.
- ↑ Newcomb, W. W.; Juhas, R. M.; Thomsen, D. R.; Homa, F. L.; Burch, A. D.; Weller, S. K.; Brown, J. C. (November 9, 2001). "The UL6 gene product forms the portal for entry of DNA into the herpes simplex virus capsid". Journal of Virology. 75 (22): 10923–10932. doi:10.1128/JVI.75.22.10923-10932.2001. PMC 114672 . PMID 11602732.
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