John E. Niederhuber

Last updated
John E. Niederhuber, MD Jniederhuber-photo.jpg
John E. Niederhuber, MD

John E. Niederhuber, MD was the 13th director of the National Cancer Institute (NCI), [1] from 2006 until July, 2010, succeeding Andrew von Eschenbach, who went on to become a director at biotechnology firm BioTime.[ clarification needed ] A nationally renowned surgeon and researcher, Dr. Niederhuber has dedicated his four-decade career to the treatment and study of cancer - as a professor, cancer center director, [2] National Cancer Advisory Board chair, external advisor to the NCI, grant reviewer, and laboratory investigator supported by NCI and the National Institutes of Health. He is now Executive Vice President/CEO Inova Translational Medicine Institute and Inova Health System and co-director, Johns Hopkins Clinical Research Network. [3]

Contents

Dr. Niederhuber at work. Dr John E Niederhuberat work.jpg
Dr. Niederhuber at work.

Research work

In addition to his management of NCI, Dr. Niederhuber remained involved in research, through his laboratory on the National Institutes of Health campus. Under his leadership, the Laboratory of Tumor and Stem Cell Biology, which is a part of the Cell and Cancer Biology Branch of NCI's Center for Cancer Research, is studying tissue stem cells as the cell-of-origin for cancer. He is working to identify, fully characterize, and isolate this population of cells, with the hypothesis that they might become a therapeutic target. The lab is also studying the complex relationship between tumor cells and their microenvironment. Studies focus on how normal stroma (connective tissue) is changed during tumor progression and on strategies for preventing the development of tumors by manipulating the microenvironment. While at NCI, Dr. Niederhuber began The Cancer Genome Atlas (TCGA), and he had important impact in the areas of nanobiology and subcellular imaging of cancer. [4]

Surgical work

While at NCI, Dr. Niederhuber also held a clinical appointment on the NIH Clinical Center Medical Staff.

As a surgeon, Dr. Niederhuber's clinical emphasis is on gastrointestinal cancer, hepatobiliary (liver, bile duct, and gallbladder) cancer, and breast cancer. He is recognized for his pioneering work in hepatic artery infusion chemotherapy and was the first to demonstrate the feasibility of totally implantable vascular access devices.

Earlier career

Prior to his current appointment, Dr. Niederhuber was NCI's Chief Operating Officer and deputy director for Translational and Clinical Sciences, a position he assumed in September 2005. In June 2002, President Bush appointed Dr. Niederhuber as Chair of the National Cancer Advisory Board. He resigned that position in order to become NCI's Deputy Director.

Before joining the Institute in a full-time capacity, Dr. Niederhuber was a Professor of Surgery and Oncology at the University of Wisconsin School of Medicine. He also served as Director of the University of Wisconsin Comprehensive Cancer Center, from July 1997 until October 2002. Earlier in his career, Dr. Niederhuber chaired the Department of Surgery at Stanford University.

Dr. Niederhuber is a board member of C-Change, an organization led by former president and Mrs. Bush and Sen. Dianne Feinstein. He served as vice-chair of the C-Change Business Planning and Budget committee from 2002 to 2004. He is a member of the prestigious CEO Roundtable and has served that organization as co-chair of its task force to develop a plan for future oncology development. Dr. Niederhuber has been a member of the Society of Surgical Oncology since 1978 and served as its president from 2001 to 2002. He was president of the Association of American Cancer Institutes from 2001 to 2003 and was a founding member (and executive committee member) of the American College of Surgeons Oncology Cooperative Group. He was a member of the American College of Surgeons Commission on Cancer from 1983 to 1995, chairing the commission from 1989 to 1990.

Over his career, Dr. Niederhuber has been a long-time external advisor to the National Cancer Institute. He served as a member of the NCI Cancer Centers Review Committee from 1984 to 1986 and was, from 1986 to 1991, a member of the NCI Division of Cancer Treatment's Board of Scientific Counselors, which he chaired from 1987 to 1991. He was a member of the National Cancer Advisory Board's Subcommittee to Evaluate the National Cancer Program (Committee to Assess Measures of Progress Against Cancer) and chaired the Molecular Medicine Panel from 1993 to 1995.

Among his numerous other board and committee memberships, Dr. Niederhuber served on the General Motors Cancer Research Foundation Kettering Prize Selection Committee (1988-1989) and twice served on the GMCRF Awards Assembly, from 1988 to 1992 and from 1998 to 2002. He chaired the American Society of Clinical Oncology Surgical Oncology Task Force for the 2001-2002 strategic planning process and the ASCO Public Policy and Practice Committee, in 2002 and 2003. He served as a member of the Burroughs-Wellcome Foundation Translational Research Advisory Committee from 1999 to 2006.

Education

Dr. Niederhuber is a graduate of Bethany College in West Virginia and the Ohio State University School of Medicine. He was an NIH Academic Trainee in Surgery at the University of Michigan from 1969 to 1970 and was a visiting fellow in the Division of Immunology at The Karolinska Institute in Stockholm, Sweden from 1970 to 1971. He completed his training in surgery at the University of Michigan in 1973 and was a member of the faculty of the University of Michigan from 1973 to 1987, being promoted to Professor of Microbiology/Immunology and Professor of Surgery in 1980. During 1986 and 1987, he was visiting professor in the Department of Molecular Biology and Genetics at The Johns Hopkins University School of Medicine in Baltimore, Md.

Dr. Niederhuber joined the faculty at Johns Hopkins in 1987 as Professor of Surgery, Oncology, and Molecular Biology and Genetics. In 1991, he was appointed Emile Holman Professor of Surgery, Professor of Microbiology and Immunology, and Chair of the Department of Surgery, Stanford University. He left Stanford in 1997 to become the Director of the University of Wisconsin Comprehensive Cancer Center, where he guided the consolidation of the university's two distinguished NCI-supported cancer centers.

Awards

Dr. Niederhuber has received a U.S. Public Health Service Career Development Award from the National Institute of Allergy and Infectious Diseases and the Distinguished Faculty Service Award from the University of Michigan. He has also been recognized with the Alumni Achievement Award from The Ohio State University College of Medicine in 1989 and the Distinguished Alumni Award in Medicine from Bethany College in 1995. Dr. Niederhuber was elected to Who's Who in America in 1998 and Who's Who in Medicine and Health Care in 1997. In addition, he has received numerous honorary professorships and is currently serving on the editorial board of 10 scientific journals. Dr. Niederhuber was a member of the editorial board of the Journal of Clinical Oncology, from 1993 to 1995. He has authored and coauthored more than 180 publications and edited four books, including (with distinguished colleagues) the highly regarded reference text Clinical Oncology, currently in its third edition.

Related Research Articles

The National Cancer Institute (NCI) coordinates the United States National Cancer Program and is part of the National Institutes of Health (NIH), which is one of eleven agencies that are part of the U.S. Department of Health and Human Services. The NCI conducts and supports research, training, health information dissemination, and other activities related to the causes, prevention, diagnosis, and treatment of cancer; the supportive care of cancer patients and their families; and cancer survivorship.

European Organisation for Research and Treatment of Cancer

The European Organisation for Research and Treatment of Cancer (EORTC) is a unique pan-European non-profit clinical cancer research organisation established in 1962 operating as an international association under Belgium law. It develops, conducts, coordinates and stimulates high-quality translational and clinical trial research to improve the survival and quality of life of cancer patients. This is achieved through the development of new drugs and other innovative approaches, and the testing of more effective therapeutic strategies, using currently approved drugs, surgery and/or radiotherapy in clinical trials conducted under the auspices of a vast network of clinical cancer researchers supported by 220 staff members based in Brussels. The EORTC has the expertise to conduct large and complex trials especially specific populations such as the older patient and rare tumours.

Cancer and Leukemia Group B U.S. research cooperative group

Cancer and Leukemia Group B is a cancer research cooperative group in the United States.

Steven Libutti American surgeon and scientist

Steven Kenneth Libutti, F.A.C.S. is an American surgeon and scientist. In January 2017, he became the third permanent Director of the Rutgers Cancer Institute of New Jersey, Vice Chancellor for Cancer Programs for Rutgers Biomedical and Health Sciences and the Senior Vice President for Oncology Services for RWJBarnabas Health, the largest health system in New Jersey. He is a tenured Professor of Surgery at the Rutgers Robert Wood Johnson Medical School. Libutti's work on the study of tumor angiogenesis and the tumor microenvironment has led to novel approaches for the treatment of cancer. He is also one of the pioneers of regional and targeted cancer therapy.

Edison Liu

Edison T. Liu, M.D. is the former president and CEO of The Jackson Laboratory, and the former director of its NCI-designated Cancer Center (2012-2021). As CEO of The Jackson Laboratory, the organization doubled revenue, faculty and personnel, expanded globally from two campuses to six, established 13 endowed chairs, and increased the institutional endowment by five-fold. He is currently a Professor and Honorary Fellow at the institution. Before joining The Jackson Laboratory, he was the founding executive director of the Genome Institute of Singapore (GIS), chairman of the board of the Health Sciences Authority, and president of the Human Genome Organization (HUGO) (2007-2013). As the executive director of the GIS, he brought the institution to international prominence as one of the most productive genomics institutions in the world.

University of Wisconsin Carbone Cancer Center

The University of Wisconsin Carbone Cancer Center (UWCCC) is a comprehensive cancer center in Wisconsin, as designated by the National Cancer Institute (NCI), the lead federal agency for cancer research. It is an integral part of both the University of Wisconsin (UW) and the University of Wisconsin Hospital and Clinics. It is located in Madison, Wisconsin.

Larry Kwak American cancer researcher

Larry Kwak is an American cancer researcher who works at City of Hope in Duarte, California and is the Director of the Toni Stephenson Lymphoma Center at City of Hope. Dr. Kwak formerly worked at the University of Texas MD Anderson Cancer Center. He was included on Time's list of 2010's most influential people.

Robert E. Wittes was Physician-in-Chief of Memorial Sloan-Kettering Cancer Center, from 2002 until December 31, 2012. Prior to his appointment at MSKCC, he was Deputy Director for Extramural Sciences and Director of the Division of Cancer Treatment and Diagnosis at the National Cancer Institute, where he oversaw NCI's extramural clinical and basic research programs, including the evaluation of new therapeutics, diagnostics, and translational research. Wittes is a fellow of the American College of Physicians, a member of the American Association for Cancer Research, the American Society of Clinical Oncology, and the American Federation for Medical Research. In addition to his institutional affiliations, Dr. Wittes has served as editor-in-chief of the Journal of the National Cancer Institute and Oncology. He has served on the editorial boards of Clinical Cancer Research, Current Opinion in Oncology, The American Journal of Clinical Oncology; Cancer Investigation, and The International Journal of Radiation Oncology-Biology & Physics, among others.

Professor Minesh P. Mehta, MD, FASTRO, is an American radiation oncologist and physician-scientist of Indian origin, Ugandan birth, Zambian Schooling and American Training, who contributed to the field of oncology for more than two and half decades.

Timothy J. Yeatman

Timothy Joseph Yeatman, M.D. F.A.C.S. is currently the Executive Medical Director of Oncologic Services and the Senior Medical Director for the Oncology Clinical Program at Intermountain Healthcare, serving 23 hospitals and >6000 patients across the State of Utah and Beyond. He is also Professor of Surgery at the University of Utah and a Member of the Huntsman Cancer Institute’s Cellular Response and Regulation Program. Previously, Dr Yeatman was the Director of Gibbs Cancer Center and President of Gibbs Cancer Center & Research Institute in Spartanburg, South Carolinawhere he founded the Guardian Research Network, a Nobel approach to clinical trials leveraging the entire EHR for real time database queries for trial candidates. Yeatman held numerous positions at the Moffitt Cancer Center (MCC) in Florida over the past 20 years. Yeatman served as the associate center director for clinical investigations, the associate center director for translational research, the executive vice president for translational research, professor of surgery and oncologic sciences, and section head of hepatobiliary surgery at the Moffitt Cancer Center and the University of South Florida. There he led a $100m Moffitt:Merck collaboration and co-founded a Nobel biotech company, M2Gen. He was recently named chief scientific officer for the Center for Advancement of Science in Space (CASIS), a non-profit organization appointed by Congress and funded by NASA to oversee all scientific use of the International Space Station. He continues to be NCI funded to perform colorectal cancer research in genomics and Biomarker development.

Waun Ki Hong was Professor of Medicine at The University of Texas MD Anderson Cancer Center, where he served as chairman of the Department of Thoracic/Head & Neck Medical Oncology from 1993 to 2005 and as head of the Division of Cancer Medicine from 2001 to 2014. He was also an American Cancer Society Professor and the Samsung Distinguished University Chair in Cancer Medicine emeritus.

J. William Harbour American ophthalmologist and researcher

J. William Harbour, M.D., is an American ophthalmologist, ocular oncologist and cancer researcher. He is currently Chair of the Department of Ophthalmology at the University of Texas Southwestern Medical Center in Dallas. He previously served as the vice chair and director of ocular oncology at the Bascom Palmer Eye Institute and associate director for basic science at the Sylvester Comprehensive Cancer Center of the University of Miami's Miller School of Medicine.

William Kaelin Jr.

William G. Kaelin Jr. is an American Nobel Laureate physician-scientist. He is a professor of medicine at Harvard University and the Dana-Farber Cancer Institute. His laboratory studies tumor suppressor proteins. In 2016, Kaelin received the Albert Lasker Award for Basic Medical Research and the AACR Princess Takamatsu Award. He also won the Nobel Prize in Physiology or Medicine in 2019 along with Peter J. Ratcliffe and Gregg L. Semenza.

Elizabeth Jaffee American oncologist

Elizabeth M. Jaffee is an American oncologist specializing in pancreatic cancer and immunotherapy.

David Gius American physician-scientist

David R. Gius is an American physician-scientist the Zell Family Scholar Professor, Women's Cancer Research Program director, and Vice Chair of Translational Research at Northwestern University's Feinberg School of Medicine Department of Radiation Oncology and Pharmacology. His research focuses into the mechanistic connection between aging, cellular and/or mitochondrial metabolism, and carcinogenesis focusing on the Sirtuin gene family.

Deborah E. Citrin American clinician and scientist

Deborah E. Citrin is an American clinician-scientist researching pre-clinical and clinical testing of radiation modifiers and the mechanisms of normal tissue injury from radiation. She is a senior investigator and deputy director of the National Cancer Institute's Center for Cancer Research.

Amy K. LeBlanc American veterinarian scientist

Amy K. LeBlanc is an American veterinary oncologist and biologist researching animal modeling for development of new cancer drugs and imaging agents, and identification of imaging biomarkers, development and optimization of PET imaging hardware and imaging protocols. She is a senior scientist in the molecular imaging program and director of the Comparative Oncology Program at the National Cancer Institute. LeBlanc was previously an associate professor at the University of Tennessee College of Medicine and College of Veterinary Medicine.

Jacqueline Whang-Peng Taiwanese-American physician-scientist

Jacqueline Jia-Kang Whang-Peng is a Taiwanese-American physician-scientist specialized in cytogenetics of cancer, as well as medical genetics, genetic oncology, and gene mapping. She was a researcher at the National Cancer Institute from 1960 to 1993.

Electron Kebebew

Electron Kebebew, M.D., is an American surgeon, educator, and scientist. Kebebew is currently the Harry A. Oberhelman Jr. and Mark L. Welton Professor and Chief of General Surgery at Stanford University. Kebebew is internationally known for his clinical and research expertise in endocrine surgery and oncology.

Soma Sengupta Scientist and neuro-oncologist

Soma Sengupta is a British-American and a specialty board certified neuro-oncologist board certified Neurologist. She is an Associate Professor of Neurology and Rehabilitation Medicine at the University of Cincinnati, with appointments in Cancer Biology and Neurosurgery. She is also affiliated with Cincinnati Children's Hospital Medical Center.

References

  1. "Dr. John E. Niederhuber, Director, NCI". NCI. 2007-05-29. Archived from the original on 2009-09-23. Retrieved 2009-11-08.
  2. "SCIENTIFIC MANAGEMENT REVIEW BOARD REPORT ON THE NIH CLINICAL CENTER" (PDF). nih.gov. National Institutes of Health. 1 Dec 2010. Retrieved 7 Nov 2018.
  3. "John E. Niederhuber, MD". Johns Hopkins Institute for Clinical and Translational Research. 2011. Archived from the original on 2012-12-10. Retrieved 2012-08-14.
  4. "John E. Niederhuber, MD". Johns Hopkins Institute for Clinical and Translational Research. 2011. Archived from the original on 2012-12-10. Retrieved 2012-08-14.
Government offices
Preceded by13th Director of the National Cancer Institute
2006 – 2010
Succeeded by