John H. Miller Jr.

Last updated
John Harris Miller, Jr.
Born
United States
Alma mater Northwestern University (B.S.)
University of Illinois at Urbana-Champaign (Ph.D)
Known for Charge density wave
Impedance spectroscopy of living organisms
Scientific career
Fields Physics
Electronics
Institutions University of Illinois
University of North Carolina at Chapel Hill
University of Houston
Doctoral advisor John Bardeen
J. R. Tucker

John Harris Miller Jr. is an American physicist with important contributions to the fields of physics, biophysics, Impedance spectroscopy, and material science, mainly known for his role in Charge density wave (in explaining the collective quantum transport of electrons in charge density waves), research work on Cuprates and Impedance spectroscopy of living organisms. [1] [2] [3] [4] He is particularly known for an effect "Collective Quantum Tunneling of CDW Electrons" [5] and for a well-known paper on the topic written by him and his colleagues, as published in Physical Review Letters. [6] He was a noteworthy student of the twice Nobel laureate physicist John Bardeen who mentioned him at several places in his biography "True Genius: The Life and Science of John Bardeen" (John Bardeen) [7] (particularly in Chapter 15 of the book which discusses the work which Miller carried out under the guidance of Bardeen and J. R. Tucker).

Contents

Biography

Miller grew up in the Sangre de Cristo Mountains of northern New Mexico. His family lived in the small resort town of Red River. His parents were owners of the small beginner ski area at the Powder Puff mountain, and later Enchanted Forest Cross Country Ski Area. He attended school in Questa, New Mexico, where many descendants of the original Spanish conquistadores live, some speaking a sixteenth-century dialect of Spanish. He was a slalom, giant slalom, and downhill ski racer, first on the Red River and later on the Taos ski teams. While an undergraduate, he was a member of the Northwestern University Ski Team, acting as both captain and coach during one season.

After completing his high school, Miller completed his bachelor's degree in electrical engineering at Northwestern University (1980) and his doctorate, in 1985, from the University of Illinois at Urbana-Champaign in physics, under J. R. Tucker and John Bardeen as his advisors. His PhD project was a combined experimental-theoretical study of quantum transport of electrons in Charge density waves, as one of the last students to work with Bardeen, who was the co-inventor of the transistor and the only recipient of two Nobel laurels in physics (his second Nobel prize awarded for the BCS theory of superconductivity).

Soon after completion of his PhD, he was awarded a prestigious IBM Postdoctoral fellowship at the University of Illinois. He joined the University of North Carolina at Chapel Hill in 1986 as an assistant professor of physics, where he remained till 1989, before joining the University of Houston, Department of Physics faculty, where he continues as a full professor of physics, in addition to being the director, HTS Device, Biophysics, and Charge Transport Lab at the Texas Center for Superconductivity at University of Houston. He has held the adjunct assistant professorship of pediatric cardiology at the Baylor College of Medicine, from 1994 to 2004. In 1987 he was selected for and awarded the Alfred P. Sloan Research Fellowship.

Scientific contributions

While exploring biomedical applications of novel superconducting devices (such as SQUIDs and SQUID-based sensitive magnetometers) at the University of Houston, he laid down the foundations of a Biophysics research group in association with researchers in the Texas Medical Center (TMC) in the mid 1990s. The group has expanded and evolved significantly since then, to develop new techniques and devices to study various living organisms. His group's work on the dielectric properties of living cells and organelles led to studying the electromagnetic properties of living cells and creating collaborations with TMC researchers (including Dale Hamilton, MD) to develop electromagnetic biosensors to detect metabolic activity in mitochondria, as related to various human conditions such as obesity and its complications (under various grants funded by the National Institutes of Health with Miller as their P.I.). This led also to group's various theoretical efforts, such as development of electric field-driven torque models of the mitochondrial motor ATP synthase and efforts to understand mechanisms of disease-implicated mitochondrial mutations in the Electron transport chain, [8] [9] [10] [11] [12] as well as reports of measurement of intrinsic electromagnetic activity and noise from living yeast cells in their best metabolic conditions. [13] [14]

His group has also been involved with computational studies of localization of electron holes in the DNA, finding a correlation between sites of hole localization and nucleotide positions of human mutations in mitochondrial DNA. This has led to a (experimental as yet) computational DNA hole spectroscopy method, which they discuss in a publication, [15] in collaboration with the reputed UH evolutionary biologist Ricardo Azevedo.

Miller in association with his colleagues has recently proposed the idea of "Martian soil Biosensors" based on their developed techniques of dielectric spectroscopy. [16]

Noteworthy students/Post-docs

Honors, awards and patents

Memberships

Related Research Articles

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References

  1. ↑ Miller, J. H.; Ordóñez, C.; Prodan, E. (2000). "Time-Correlated Soliton Tunneling in Charge and Spin Density Waves". Physical Review Letters. 84 (7): 1555–1558. Bibcode:2000PhRvL..84.1555M. doi:10.1103/PhysRevLett.84.1555. PMID   11017566.
  2. ↑ Miller, J. H.; Wijesinghe, A. I.; Tang, Z.; Guloy, A. M. (2012). "Correlated Quantum Transport of Density Wave Electrons". Physical Review Letters. 108 (3): 036404. Bibcode:2012PhRvL.108c6404M. doi:10.1103/PhysRevLett.108.036404. PMC   11524153 . PMID   22400766.
  3. ↑ Miller, J. H.; Wijesinghe, A. I.; Tang, Z.; Guloy, A. M. (2013). "Coherent quantum transport of charge density waves". Physical Review B. 87 (11): 115127. arXiv: 1212.3020 . Bibcode:2013PhRvB..87k5127M. doi:10.1103/PhysRevB.87.115127.
  4. ↑ Miller, J. H.; Wijesinghe, A. I.; Tang, Z.; Guloy, A. M. (2013). "Coherent quantum transport of charge density waves". Physical Review B. 87 (11): 115127. arXiv: 1212.3020 . Bibcode:2013PhRvB..87k5127M. doi:10.1103/PhysRevB.87.115127.
  5. ↑ "UH Physicist John Miller on Collective Quantum Tunneling of CDW Electrons".
  6. ↑ Miller, J. H.; Wijesinghe, A. I.; Tang, Z.; Guloy, A. M. (2012). "Correlated Quantum Transport of Density Wave Electrons". Physical Review Letters. 108 (3): 036404. arXiv: 1109.4619 . Bibcode:2012PhRvL.108c6404M. doi:10.1103/PhysRevLett.108.036404. PMC   11524153 . PMID   22400766. S2CID   29510494.
  7. ↑ Daitch, Vicki; Hoddeson, Lillian (2002-11-28). True Genius: The Life and Science of John Bardeen: The Only Winner of Two Nobel Prizes in Physics. ISBN   0309095115.
  8. ↑ Prodan, E.; Prodan, C.; Miller Jr, J. H. (2008). "The Dielectric Response of Spherical Live Cells in Suspension: An Analytic Solution". Biophysical Journal. 95 (9): 4174–4182. doi:10.1529/biophysj.108.137042. PMC   2567925 . PMID   18658215.
  9. ↑ Miller Jr., John H.; Vajrala, Vijayanand; Infante, Hans L.; Claycomb, James R.; Palanisami, Akilan; Fang, Jie; Mercier, George T. (2009). "Physical mechanisms of biological molecular motors". Physica B: Condensed Matter. 404 (3–4): 503–506. doi:10.1016/j.physb.2008.11.037.
  10. ↑ Mercier, G.T. Skip; Palanisami, Akilan; Miller, John H. (2010). "Nonlinear dielectric spectroscopy for label-free detection of respiratory activity in whole cells". Biosensors and Bioelectronics. 25 (9): 2107–2114. doi:10.1016/j.bios.2010.02.013. PMC   2896706 . PMID   20335015.
  11. ↑ Palanisami, Akilan; Mercier, George T.; Fang, Jie; Miller Jr., John H. (2011). "Nonlinear Impedance of Whole Cells Near an Electrode as a Probe of Mitochondrial Activity". Biosensors. 1 (2): 46–57. doi: 10.3390/bios1020046 . PMC   4264341 . PMID   25586827.
  12. ↑ Padmaraj, D.; Miller Jr, J. H.; Wosik, J.; Zagozdzon-Wosik, W. (2011). "Reduction of electrode polarization capacitance in low-frequency impedance spectroscopy by using mesh electrodes". Biosensors & Bioelectronics. 29 (1): 13–17. doi:10.1016/j.bios.2011.06.050. PMID   21872464.
  13. ↑ Bukhari, M. H.; Miller, J. H. (2010). "Measurement of intrinsic physiological membrane noise in cultured living cells". Electromagnetic Biology and Medicine. 29 (1–2): 36–51. doi:10.3109/15368371003776626. PMID   20560770.
  14. ↑ Bukhari, Masroor H.S.; Miller, John H.; Jr.; Shah, Zahoor H. (2010). "Intrinsic Membrane Noise in Living Cells and Its Coupling to External Fields". 2010 Second International Conference on Computer Research and Development. pp. 540–544. doi:10.1109/ICCRD.2010.115. ISBN   978-0-7695-4043-6.
  15. ↑ Suárez, Martha Y.; Villagrán; Miller, John H. (2015). "Computational DNA hole spectroscopy: A new tool to predict mutation hotspots, critical base pairs and disease 'driver' mutations". Scientific Reports. 5: 13571. doi:10.1038/srep13571. PMC   4550865 . PMID   26310834.
  16. ↑ Martian Soil Biosensors Based on Dielectric Spectroscopy. John H. Miller, Jie Fang, David Warmflash, David S. McKay, Jeffrey A. Jones, and Fathi Karouia. ISSO Y2007, pp61-66, 2008.
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