Juan Carlos Parodi (Buenos Aires, August 16, 1942) is an Argentinian vascular surgeon who introduced the minimally invasive endovascular aneurysm repair (EVAR) to the world and performed the first successful endovascular repair of an abdominal aortic aneurysm on 7 September 1990 in Buenos Aires. [1] In 1992 he was the first in the United States to perform minimally invasive aortic aneurysm surgery [2] (stent graft procedure) together with Drs. Frank Veith, Michael L. Marin and Claudio J. Schonholz. [3] He continues to develop new techniques, including seat belt and air bag technique for cerebral protection during carotid stenting. [4] He is recognized as a renowned pioneer in the specialty of endovascular repairs of the aorta. [1] [5] [6]
Juan Parodi is also a political activist and defender of measures to alleviate poverty as well as promoter of the concept of responsible procreation and education of the most economically affected sectors in Argentina. [7] [8] [9] [10]
Juan Parodi was led to a career in surgery through his own interest and family influence - his uncle was a surgeon. In 1960 he began his medical training at the Universidad del Salvador, Buenos Aires, Argentina. After receiving an MD degree at the University of Salvador in 1968, Juan Parodi entered the general surgery residency in the former M. Castex Hospital which he finished in 1972. He did postgraduate fellowship at the University of Illinois at Chicago and following it did another one at the Cleveland Clinic with emphasis on vascular surgery. From 1975 to 1976 Parodi served as chief resident at the Cleveland Clinic, where Professor Alfred Humphries and Edwin Beven became two significant mentors in his career. It was during that last year 1976 that he committed all his wits to develop a new minimally invasive surgical technique that would change the future of the then infant specialty of vascular surgery and in particular aortic aneurysm surgery. [5]
The conception of Parodi's new minimally invasive technique started in 1976. It was aimed at excluding an aneurysm using a fabric graft and metal components to affix and seal these elements in position using an endovascular retrograde access. At that time, the term “metal cage with barbs” was used rather than “stent”. The engineering of the first prototypes using elastic wires of stainless steel and the experimental work took place at the Cleveland Clinic, USA. [1]
In 1979 he returned to Argentina where he continued working on the improvement of his minimally invasive surgical techniques. At that time, nobody paid attention to Parodi’s invention, which he continued to research without funding. By the mid 1980s, Parodi was having some success with his new technique in animal experiments. In 1988, Parodi met Argentinian radiologist Julio Palmaz, the inventor of the Palmaz stent, and Parodi began to use Palmaz stents in combination with his endografts on animals. From 1976 to 1990, Parodi did not receive any funding or support for his project. [5]
On 7 September 1990 Parodi made vascular surgery history with the first successful endograft procedure in the world, in the city of Buenos Aires. The first human being to be treated with Parodi’s endograft was fairly high profile – a friend of Carlos Menem, the then President of Argentina also a patient who received an intervención bring presidente with a team of doctora Lije Alejandro Tfeli and Luis de la Fuente. The first device was simple, according to Parodi: “It was a graft I designed with expandable ends, the extra-large Palmaz stent, a Teflon sheath with a valve, a wire, and the valvuplasty balloon, which I took from the cardiologists." Juan Parodi invited Julio Palmaz to participate in the case at the Instituto Cardiovascular de Buenos Aires. That case was a turning point in the history of vascular surgery, changing the way most patients with aneurysmal disease are treated around the world today. [1]
Despite the high profile of the patient, the procedure had little initial impact on the vascular surgery community because his initial results were rejected by the journal he submitted to. Finally in 1991 through the Annals of Vascular Surgery, the case by Juan C Parodi and Julio Palmaz became the first widely known endovascular repair (EVAR) of the aorta. In October 1992 the first EVAR case in Western Europe was done by Parodi, Claude Mialhe, Claude Amicabile and Claudio Schonholz in Nancy, France. In November 1992 Parodi was the first in the United States to perform minimally invasive aortic aneurysm surgery together with Frank Veith, Michael Marin and Claudio Schonholz. In 1995, the EVAR procedure was published in the Journal of Vascular Surgery. [11] In 2005, Juan Parodi was celebrated as the creator of the Parodi Endograft, "one of the biggest innovations in the history of vascular surgery". [5]
When he became a professor in 1993 at Universidad del Salvador, Buenos Aires, he began traveling throughout the United States and abroad. He was a visiting professor at Stanford, New York, the University of London and the University of Tokyo. He also was an honorary professor at his alma mater, University of Buenos Aires and was a professor of surgery at Wake Forest University and Washington University in St. Louis. [12] He is adjunct surgical research professor, University of Michigan, USA. [1]
In conjunction with the Research Chair at the University of Michigan, he undertook a work on the Argentine demographic growth, evaluating the projection of human quality in the coming years and with this base, he spoke at several conferences, which became very famous for making emphasis on the problems that hit your country hard, such as poverty and the poor education that this sector receives in Argentina. [13]
In 1980, Juan Parodi removed a gangrenous gall bladder from a poor Argentinian priest and did it without any payment. Years later, he found out who that poor priest was, Jorge Bergoglio. In 2014, Parodi and his wife was invited to visit that priest, now Pope Francis, at the Vatican and to be thanked for caring for another person without compensation. [1] [14] [15]
Interventional radiology (IR) is a medical specialty that performs various minimally-invasive procedures using medical imaging guidance, such as x-ray fluoroscopy, computed tomography, magnetic resonance imaging, or ultrasound. IR performs both diagnostic and therapeutic procedures through very small incisions or body orifices. Diagnostic IR procedures are those intended to help make a diagnosis or guide further medical treatment, and include image-guided biopsy of a tumor or injection of an imaging contrast agent into a hollow structure, such as a blood vessel or a duct. By contrast, therapeutic IR procedures provide direct treatment—they include catheter-based medicine delivery, medical device placement, and angioplasty of narrowed structures.
Vascular surgery is a surgical subspecialty in which vascular diseases involving the arteries, veins, or lymphatic vessels, are managed by medical therapy, minimally-invasive catheter procedures and surgical reconstruction. The specialty evolved from general and cardiovascular surgery where it refined the management of just the vessels, no longer treating the heart or other organs. Modern vascular surgery includes open surgery techniques, endovascular techniques and medical management of vascular diseases - unlike the parent specialities. The vascular surgeon is trained in the diagnosis and management of diseases affecting all parts of the vascular system excluding the coronaries and intracranial vasculature. Vascular surgeons also are called to assist other physicians to carry out surgery near vessels, or to salvage vascular injuries that include hemorrhage control, dissection, occlusion or simply for safe exposure of vascular structures.
An aortic aneurysm is an enlargement (dilatation) of the aorta to greater than 1.5 times normal size. Typically, there are no symptoms except when the aneurysm dissects or ruptures, which causes sudden, severe pain in the abdomen and lower back.
Abdominal aortic aneurysm (AAA) is a localized enlargement of the abdominal aorta such that the diameter is greater than 3 cm or more than 50% larger than normal. An AAA usually causes no symptoms, except during rupture. Occasionally, abdominal, back, or leg pain may occur. Large aneurysms can sometimes be felt by pushing on the abdomen. Rupture may result in pain in the abdomen or back, low blood pressure, or loss of consciousness, and often results in death.
A thoracic aortic aneurysm is an aortic aneurysm that presents primarily in the thorax.
A pseudoaneurysm, also known as a false aneurysm, is a locally contained hematoma outside an artery or the heart due to damage to the vessel wall. The injury passes through all three layers of the arterial wall, causing a leak, which is contained by a new, weak "wall" formed by the products of the clotting cascade. A pseudoaneurysm does not contain any layer of the vessel wall.
Traumatic aortic rupture, also called traumatic aortic disruption or transection, is a condition in which the aorta, the largest artery in the body, is torn or ruptured as a result of trauma to the body. The condition is frequently fatal due to the profuse bleeding that results from the rupture. Since the aorta branches directly from the heart to supply blood to the rest of the body, the pressure within it is very great, and blood may be pumped out of a tear in the blood vessel very rapidly. This can quickly result in shock and death. Thus traumatic aortic rupture is a common killer in automotive accidents and other traumas, with up to 18% of deaths that occur in automobile collisions being related to the injury. In fact, aortic disruption due to blunt chest trauma is the second leading cause of injury death behind traumatic brain injury.
Endovascular aneurysm repair (EVAR) is a type of minimally-invasive endovascular surgery used to treat pathology of the aorta, most commonly an abdominal aortic aneurysm (AAA). When used to treat thoracic aortic disease, the procedure is then specifically termed TEVAR for "thoracic endovascular aortic/aneurysm repair." EVAR involves the placement of an expandable stent graft within the aorta to treat aortic disease without operating directly on the aorta. In 2003, EVAR surpassed open aortic surgery as the most common technique for repair of AAA, and in 2010, EVAR accounted for 78% of all intact AAA repair in the United States.
Michael L. Marin is an American vascular surgeon. Together with Drs. Frank Veith, Juan C. Parodi and Claudio J. Schonholz, he was the first in the United States to perform minimally invasive aortic aneurysm surgery. In 2004, he was the first doctor to implant an intravascular telemetric monitor -- a device that alerts to physicians any leakage in aortic stent-grafts.
Peter Lin is an American vascular surgeon, medical researcher, specializing in minimally invasive endovascular treatment of vascular disease. He has published extensively in the area of vascular surgery and endovascular surgery.
A hybrid cardiac surgical procedure in a narrow sense is defined as a procedure that combines a conventional, more invasive surgical part with an interventional part, using some sort of catheter-based procedure guided by fluoroscopy imaging in a hybrid operating room (OR) without interruption. The hybrid technique has a reduced risk of surgical complications and has shown decreased recovery time. It can be used to treat numerous heart diseases and conditions and with the increasing complexity of each case, the hybrid surgical technique is becoming more common.
Open aortic surgery (OAS), also known as open aortic repair (OAR), describes a technique whereby an abdominal, thoracic or retroperitoneal surgical incision is used to visualize and control the aorta for purposes of treatment, usually by the replacement of the affected segment with a prosthetic graft. OAS is used to treat aneurysms of the abdominal and thoracic aorta, aortic dissection, acute aortic syndrome, and aortic ruptures. Aortobifemoral bypass is also used to treat atherosclerotic disease of the abdominal aorta below the level of the renal arteries. In 2003, OAS was surpassed by endovascular aneurysm repair (EVAR) as the most common technique for repairing abdominal aortic aneurysms in the United States.
Frank J. Veith is an American vascular surgeon who serves as Professor of Surgery, New York University Medical Center NY, NY and Professor of Surgery Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH. He was the first vascular surgeon in the United States to perform minimally invasive aortic aneurysm surgery together with Drs. Michael L. Marin, Juan C. Parodi and Claudio J. Schonholz.
Claudio J. Schonholz is an interventional radiologist, the first in the United States to perform minimally invasive aortic aneurysm surgery together with Drs. Frank Veith, Juan C. Parodi and Michael L. Marin.
Endovascular and hybrid trauma and bleeding management is a new and rapidly evolving concept within medical healthcare and endovascular resuscitation. It involves early multidisciplinary evaluation and management of hemodynamically unstable patients with traumatic injuries as well as being a bridge to definitive treatment. It has recently been shown that the EVTM concept may also be applied to non-traumatic hemodynamically unstable patients.
Nicolai Leontievich Volodos, was a Soviet/Ukrainian cardiovascular surgeon and scientist. An innovator, Volodos developed and introduced into clinical practice the world's first endovascular stent graft for the treatment of stenotic and aneurysmal diseases of arterial system. Volodos was described by his colleagues as "a pioneer innovator and a giant in vascular and endovascular surgery" and "a giant of historic proportions in the vascular and endovascular specialties, and the father of endovascular grafting".
Hazim J. Safi, MD, FACS, is a physician and surgeon who is well known for his research in the surgical treatment of aortic disease. Safi and his colleagues at Baylor College of Medicine were the first to identify variables associated with early death and postoperative complications in patients undergoing thoracoabdominal aortic operations. Safi now serves as professor of cardiothoracic surgery, and founding chair at McGovern Medical School at The University of Texas Health Science Center in Houston, TX.
Gustavo S. Oderich is a Brazilian American vascular and endovascular surgeon who serves as a professor and chief of vascular and endovascular surgery, and is the director of the Advanced Endovascular Aortic Program at McGovern Medical School at The University of Texas Health Science Center at Houston and Memorial Hermann Health System. He previously served as chair of vascular and endovascular division at the Mayo Clinic in Rochester, Minnesota. Oderich is recognized for his work in minimally invasive endovascular surgery and research in fenestrated and branched stent-graft technology to treat complex aortic aneurysms and dissections.
Benjamin Starnes is a vascular surgeon and medical researcher. He holds the Alexander Whitehill Clowes Endowed Chair in Vascular surgery at the University of Washington. He served as a U.S. Army surgeon for 15 years, doing three tours of duty, including in the last M.A.S.H. unit. On the day of the September 11 attacks he was at the Pentagon rendering medical aid to victims, and his experience was later recounted in the book American Phoenix: Heroes of the Pentagon on 9/11. He is among the primary authors of the official guidelines for diagnosis and management of aortic disease adopted by the American College of Cardiology and the American Heart Association.
Roger Malcolm Greenhalgh was a British surgeon, researcher and educator best known for his contributions to the field of vascular surgery. He was emeritus Professor of Surgery at Imperial College London in London, England and Head of the Imperial College Vascular Surgery Research Group at the time of his death.
On 7 September 1990, a 70-year-old man with severe chronic obstructive pulmonary disease and severe back pain caused by a 6cm abdominal aortic aneurysm underwent the first successful endovascular aneurysm repair (EVAR) in the Western world. The case by Juan C Parodi and Julio Palmaz became the first widely known endovascular repair of the aorta and was described the following year in the Annals of Vascular Surgery. On the 25th anniversary of that landmark case, we dedicate these pages to some of the EVAR pioneers.
Vascular News talks to Juan Parodi – professor of surgery at the Washington University School of Medicine and creator of the Parodi Endograft, one of the biggest innovations in the history of vascular surgery.
Parodi, who was delivering this year's International Lecture as part of SVS ONLINE, is the 2020 recipient of the Society for Vascular Surgery (SVS) International Lifetime Achievement Award.
at the 48:58 min. mark: My Experience with Pope Francis