KATNB1

Last updated
KATNB1
Identifiers
Aliases KATNB1 , KAT, LIS6, katanin regulatory subunit B1
External IDs OMIM: 602703; MGI: 1921437; HomoloGene: 4302; GeneCards: KATNB1; OMA:KATNB1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005886

NM_028805

RefSeq (protein)

NP_005877

NP_083081

Location (UCSC) Chr 16: 57.74 – 57.76 Mb Chr 8: 95.81 – 95.83 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Katanin p80 WD40-containing subunit B1 is a protein that in humans is encoded by the KATNB1 gene. [5] [6]

Contents

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases. [6] KATNB1 is associated with microlissencephaly.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000140854 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031787 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hartman JJ, Mahr J, McNally K, Okawa K, Iwamatsu A, Thomas S, Cheesman S, Heuser J, Vale RD, McNally FJ (May 1998). "Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit". Cell. 93 (2): 277–87. doi: 10.1016/S0092-8674(00)81578-0 . PMID   9568719. S2CID   13583382.
  6. 1 2 "Entrez Gene: KATNB1 katanin p80 (WD repeat containing) subunit B 1".

Further reading