KCTD13

KCTD13
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UIJ
Identifiers
Aliases	KCTD13 , BACURD1, PDIP1, POLDIP1, hBACURD1, FKSG86, potassium channel tetramerization domain containing 13
External IDs	OMIM: 608947 MGI: 1923739 HomoloGene: 27800 GeneCards: KCTD13
Gene location (Human)
Chr.	Chromosome 16 (human)
End	29,926,236 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	126,544,803 bp
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; prefrontal cortex; ; amygdala; ; Region I of hippocampus proper; ; caudate nucleus; ; putamen; ; Brodmann area 9; ; oocyte; ; anterior pituitary; ; sperm;
	Top expressed in
	superior frontal gyrus; ; subiculum; ; dentate gyrus; ; piriform cortex; ; globus pallidus; ; cingulate gyrus; ; hippocampus proper; ; olfactory tubercle; ; pontine nuclei; ; primary motor cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	ubiquitin-protein transferase activity ; protein binding ; identical protein binding ; protein domain specific binding ;
Cellular component	Cul3-RING ubiquitin ligase complex ; nucleus ; nuclear body ;
Biological process	positive regulation of DNA replication ; DNA replication ; protein homooligomerization ; cell migration ; protein ubiquitination ; stress fiber assembly ; proteasome-mediated ubiquitin-dependent protein catabolic process ; negative regulation of Rho protein signal transduction ; positive regulation of synaptic transmission ; neural precursor cell proliferation ;
	Sources:Amigo / QuickGO
Orthologs
	253980
	233877
	ENSG00000174943
	ENSMUSG00000030685
	Q8WZ19
	Q8BGV7
	NM_178863
	NM_172747
	NP_849194
	NP_766335
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 04, 2024

BTB/POZ domain-containing protein KCTD13 is a protein that in humans is encoded by the KCTD13 gene.^[5]^[6]

Interactions

KCTD13 has been shown to interact with PCNA.^[5]

Clinical relevance

Mutations in this gene have been associated to abnormalities in brain growth and behaviour.^[7]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000174943 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030685 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 He H, Tan CK, Downey KM, So AG (October 2001). "A tumor necrosis factor alpha- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase delta and proliferating cell nuclear antigen". Proceedings of the National Academy of Sciences of the United States of America. 98 (21): 11979–84. Bibcode:2001PNAS...9811979H. doi: 10.1073/pnas.221452098 . PMC 59753 . PMID 11593007.
↑ "Entrez Gene: KCTD13 potassium channel tetramerisation domain containing 13".
↑ Arbogast T, Razaz P, Ellegood J, McKinstry SU, Erdin S, Currall B, et al. (May 2019). "Kctd13-deficient mice display short-term memory impairment and sex-dependent genetic interactions". Human Molecular Genetics. 28 (9): 1474–1486. doi:10.1093/hmg/ddy436. PMC 6489413 . PMID 30590535.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human KCTD13

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000174943 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030685 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11593007-5] 1 2 He H, Tan CK, Downey KM, So AG (October 2001). "A tumor necrosis factor alpha- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase delta and proliferating cell nuclear antigen". Proceedings of the National Academy of Sciences of the United States of America. 98 (21): 11979–84. Bibcode:2001PNAS...9811979H. doi: 10.1073/pnas.221452098 . PMC 59753 . PMID 11593007.

[entrez-6] "Entrez Gene: KCTD13 potassium channel tetramerisation domain containing 13".

[7] Arbogast T, Razaz P, Ellegood J, McKinstry SU, Erdin S, Currall B, et al. (May 2019). "Kctd13-deficient mice display short-term memory impairment and sex-dependent genetic interactions". Human Molecular Genetics. 28 (9): 1474–1486. doi:10.1093/hmg/ddy436. PMC 6489413 . PMID 30590535.

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