KCTD13

KCTD13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UIJ
Identifiers
Aliases	KCTD13 , BACURD1, PDIP1, POLDIP1, hBACURD1, FKSG86, potassium channel tetramerization domain containing 13
External IDs	OMIM: 608947; MGI: 1923739; HomoloGene: 27800; GeneCards: KCTD13; OMA:KCTD13 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p11.2 Start 29,905,012 bp [1] End 29,926,236 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 F3 Start 126,528,051 bp [2] End 126,544,803 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis nucleus accumbens anterior cingulate cortex right frontal lobe prefrontal cortex amygdala Region I of hippocampus proper caudate nucleus right hemisphere of cerebellum Top expressed in primary visual cortex superior frontal gyrus subiculum zygote dentate gyrus dentate gyrus of hippocampal formation granule cell piriform cortex globus pallidus cingulate gyrus hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin-protein transferase activity protein binding identical protein binding protein domain specific binding Cellular component Cul3-RING ubiquitin ligase complex nucleus nuclear body Biological process positive regulation of DNA replication DNA replication protein homooligomerization cell migration protein ubiquitination stress fiber assembly proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of Rho protein signal transduction positive regulation of synaptic transmission neural precursor cell proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 253980 233877 Ensembl ENSG00000174943 ENSMUSG00000030685 UniProt Q8WZ19 Q8BGV7 RefSeq (mRNA) NM_178863 NM_172747 RefSeq (protein) NP_849194 NP_766335 Location (UCSC) Chr 16: 29.91 – 29.93 Mb Chr 7: 126.53 – 126.54 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

BTB/POZ domain-containing protein KCTD13 is a protein that in humans is encoded by the KCTD13 gene. ^{[5] [6]}

Interactions

KCTD13 has been shown to interact with PCNA. ^[5]

Clinical relevance

Mutations in this gene have been associated to abnormalities in brain growth and behaviour. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000174943 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030685 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. He H, Tan CK, Downey KM, So AG (October 2001). "A tumor necrosis factor alpha- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase delta and proliferating cell nuclear antigen". Proceedings of the National Academy of Sciences of the United States of America. 98 (21): 11979–84. Bibcode:2001PNAS...9811979H. doi: 10.1073/pnas.221452098 . PMC   59753 . PMID   11593007.
6. "Entrez Gene: KCTD13 potassium channel tetramerisation domain containing 13".
7. Arbogast T, Razaz P, Ellegood J, McKinstry SU, Erdin S, Currall B, et al. (May 2019). "Kctd13-deficient mice display short-term memory impairment and sex-dependent genetic interactions". Human Molecular Genetics. 28 (9): 1474–1486. doi:10.1093/hmg/ddy436. PMC   6489413 . PMID   30590535.

Further reading

• Kutsenko AS, Gizatullin RZ, Al-Amin AN, Wang F, Kvasha SM, Podowski RM, et al. (July 2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome". Nucleic Acids Research. 30 (14): 3163–70. doi:10.1093/nar/gkf428. PMC   135748 . PMID   12136098.
• Zhou J, Hu X, Xiong X, Liu X, Liu Y, Ren K, et al. (March 2005). "Cloning of two rat PDIP1 related genes and their interactions with proliferating cell nuclear antigen". Journal of Experimental Zoology A. 303 (3): 227–40. Bibcode:2005JEZA..303..227Z. doi:10.1002/jez.a.150. PMID   15726626.
• Tomaru T, Satoh T, Yoshino S, Ishizuka T, Hashimoto K, Monden T, et al. (January 2006). "Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the deoxyribonucleic acid-binding domain of peroxisome proliferator-activated receptor-gamma". Endocrinology. 147 (1): 377–88. doi: 10.1210/en.2005-0450 . PMID   16239304.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human KCTD13