KCTD15

Last updated
KCTD15
Identifiers
Aliases KCTD15 , potassium channel tetramerization domain containing 15
External IDs OMIM: 615240 MGI: 2385276 HomoloGene: 11450 GeneCards: KCTD15
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001129994
NM_001129995
NM_024076

NM_146188
NM_001360818
NM_001360820

RefSeq (protein)

NP_001123466
NP_001123467
NP_076981

NP_666300
NP_001347747
NP_001347749

Location (UCSC) Chr 19: 33.8 – 33.82 Mb Chr 7: 34.64 – 34.66 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Potassium channel tetramerisation domain containing 15 also known as BTB/POZ domain-containing protein KCTD15 is protein that in humans is encoded by the KCTD15 gene. [5]

Contents

Clinical significance

Variants of the KCTD15 gene may be associated with obesity. [6] [7] [8]

See also

Related Research Articles

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Genetics of obesity

Like many other medical conditions, obesity is the result of an interplay between environmental and genetic factors. Studies have identified variants in several genes that may contribute to weight gain and body fat distribution; although, only in a few cases are genes the primary cause of obesity.

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000153885 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030499 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Strausberg RL, Feingold EA, Grouse LH, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
  6. Thorleifsson G, Walters GB, Gudbjartsson DF, et al. (January 2009). "Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity". Nat. Genet. 41 (1): 18–24. doi:10.1038/ng.274. PMID   19079260. S2CID   764409.
  7. Willer CJ, Speliotes EK, Loos RJ, et al. (January 2009). "Six new loci associated with body mass index highlight a neuronal influence on body weight regulation". Nat. Genet. 41 (1): 24–34. doi:10.1038/ng.287. PMC   2695662 . PMID   19079261.
  8. Zhao J, Bradfield JP, Li M, et al. (May 2009). "The role of obesity-associated loci identified in genome wide association studies in the determination of pediatric BMI". Obesity (Silver Spring). 17 (12): 2254–7. doi:10.1038/oby.2009.159. PMC   2860782 . PMID   19478790.

Further reading