KDELR3

KDELR3
Identifiers
Aliases	KDELR3 , ERD2L3, KDEL endoplasmic reticulum protein retention receptor 3
External IDs	MGI: 2145953 HomoloGene: 68533 GeneCards: KDELR3
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q13.1 Start 38,468,078 bp [1] End 38,483,447 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 E1 Start 79,400,612 bp [2] End 79,411,940 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia parotid gland periodontal fiber stromal cell of endometrium pancreatic ductal cell jejunal mucosa parietal pleura germinal epithelium rectum gallbladder Top expressed in calvaria molar body of femur belly cord dermis ascending aorta ankle joint fossa aortic valve external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ER retention sequence binding KDEL sequence binding Cellular component integral component of membrane endoplasmic reticulum membrane membrane transport vesicle Golgi membrane endoplasmic reticulum Golgi apparatus cis-Golgi network COPI-coated vesicle membrane cytoplasmic vesicle Biological process protein transport protein retention in ER lumen IRE1-mediated unfolded protein response vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum endoplasmic reticulum to Golgi vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11015 105785 Ensembl ENSG00000100196 ENSMUSG00000010830 UniProt O43731 Q8R1L4 RefSeq (mRNA) NM_016657 NM_006855 NM_134090 RefSeq (protein) NP_006846 NP_057839 NP_598851 Location (UCSC) Chr 22: 38.47 – 38.48 Mb Chr 15: 79.4 – 79.41 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ER lumen protein retaining receptor 3 is a protein that in humans is encoded by the KDELR3 gene. ^[5]

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, lys-asp-glu-leu (KDEL) in animal cells and his-asp-glu-leu (HDEL) in S. cerevisiae . This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified, and it encodes a protein highly homologous to KDELR1 and KDELR2 proteins. Two transcript variants of KDELR3 that arise by alternative splicing, and encode different isoforms of KDELR3 receptor, have been described. ^[5]

See also

• KDELR1
• KDELR2

References

1. GRCh38: Ensembl release 89: ENSG00000100196 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000010830 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3".

Further reading

• Pelham HR (1997). "The dynamic organisation of the secretory pathway". Cell Struct. Funct. 21 (5): 413–9. doi: 10.1247/csf.21.413 . PMID   9118249.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC   545604 . PMID   15461802.
• Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC   430954 . PMID   12529303.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID   10591208.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.