Lysine demethylase 8 is a protein that in humans is encoded by the KDM8 gene. [5]
Lysine demethylase 8 is a protein that in humans is encoded by the KDM8 gene. [5]
This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described.
Lysine-specific demethylase 4A is an enzyme that in humans is encoded by the KDM4A gene.
Large tumor suppressor kinase 2 (LATS2) is an enzyme that in humans is encoded by the LATS2 gene.
Lysine-specific demethylase 5C is an enzyme that in humans is encoded by the KDM5C gene. KDM5C belongs to the alpha-ketoglutarate-dependent hydroxylase superfamily.
Lysine-specific demethylase 3B is an enzyme that in humans is encoded by the KDM3B gene. KDM3B belongs to the alpha-ketoglutarate-dependent hydroxylase superfamily.
PHD finger protein 20 is a protein that in humans is encoded by the PHF20 gene.
Myosin-XVIIIb is a protein that in humans is encoded by the MYO18B gene.
Nitrogen permease regulator 2-like protein (NPRL2) also known as tumor suppressor candidate 4 (TUSC4) is a protein that in humans is encoded by the NPRL2 gene.
Transmembrane protein 158 is a protein that in humans is encoded by the TMEM158 gene.
Sestrin 1, also known as p53-regulated protein PA26, is a protein that in humans is encoded by the SESN1 gene. This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Calpain-6 is a protein in humans that is encoded by the CAPN6 gene.
Splicing factor, suppressor of white-apricot homolog is a protein in humans that is encoded by the SFSWAP gene.
Leucine zipper, putative tumor suppressor family member 3 is a protein in humans that is encoded by the LZTS3 gene.
Suppressor of cytokine signaling 4 is a protein that in humans is encoded by the SOCS4 gene.
Lysine demethylase 3A is a protein that in humans is encoded by the KDM3A gene.
Jumonji domain containing 1C is a protein that in humans is encoded by the JMJD1C gene.
Lysine demethylase 7A is a protein that in humans is encoded by the KDM7A gene.
Transmembrane and immunoglobulin domain containing 1 is a protein that in humans is encoded by the TMIGD1 gene. TMIGD1 was discovered by the lab of Giancarlo Marra and later cloned by Nader Rahimi. Recent findings suggest functions in brush border formation and roles as tumor suppressor.
Nuclear export mediator factor (NEMF) is a protein that in humans is encoded by the NEMF gene.
Transmembrane protein 127 (TMEM127) is a transmembrane protein which is encoded by the TMEM127 gene. It has been demonstrated to be a negative regulator MTOR signalling. TMEM127 is a tumor suppressor gene, inactivating germline mutations in which causes hereditary pheochromocytoma and paraganglioma.
DExH-box helicase 34 is a protein that in humans is encoded by the DHX34 gene.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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