KIN (gene)

KIN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CKK, 2V1N
Identifiers
Aliases	KIN , BTCD, KIN17, Rts2, Kin17 DNA and RNA binding protein
External IDs	OMIM: 601720 MGI: 96676 HomoloGene: 8196 GeneCards: KIN
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10p14 Start 7,750,962 bp [1] End 7,787,993 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 A1 Start 10,085,404 bp [2] End 10,097,617 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte Achilles tendon ganglionic eminence left lobe of thyroid gland popliteal artery body of pancreas left uterine tube ascending aorta left coronary artery endothelial cell Top expressed in Ankle joint yolk sac ganglionic eminence thymus supraoptic nucleus morula ascending aorta maxillary prominence secondary oocyte primitive streak More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding double-stranded DNA binding metal ion binding RNA binding protein binding Cellular component cytoplasm nuclear matrix intracellular membrane-bounded organelle nucleus nucleoplasm protein-containing complex Biological process DNA replication mRNA processing DNA recombination viral process DNA repair cellular response to DNA damage stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22944 16588 Ensembl ENSG00000151657 ENSMUSG00000037262 UniProt O60870 Q8K339 RefSeq (mRNA) NM_012311 NM_025280 RefSeq (protein) NP_036443 NP_079556 Location (UCSC) Chr 10: 7.75 – 7.79 Mb Chr 2: 10.09 – 10.1 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DNA/RNA-binding protein KIN17 is a protein that in humans is encoded by the KIN gene. ^{[5] [6]}

The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000151657 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037262 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Angulo JF, Rouer E, Mazin A, Mattei MG, Tissier A, Horellou P, Benarous R, Devoret R (Nov 1991). "Identification and expression of the cDNA of KIN17, a zinc-finger gene located on mouse chromosome 2, encoding a new DNA-binding protein". Nucleic Acids Res. 19 (19): 5117–23. doi:10.1093/nar/19.19.5117. PMC   328864 . PMID   1923796.
6. "Entrez Gene: KIN KIN, antigenic determinant of recA protein homolog (mouse)".

Further reading

• Biard DS, Saintigny Y, Maratrat M, et al. (1997). "Differential expression of the HsKin17 protein during differentiation of in vitro reconstructed human skin" (PDF). Arch. Dermatol. Res. 289 (8): 448–56. doi:10.1007/s004030050220. PMID   9266022. S2CID   25828778.
• Kannouche P, Angulo JF (1999). "Overexpression of kin17 protein disrupts nuclear morphology and inhibits the growth of mammalian cells". J. Cell Sci. 112 (19): 3215–24. doi:10.1242/jcs.112.19.3215. PMID   10504327.
• Blattner C, Kannouche P, Litfin M, et al. (2000). "UV-Induced stabilization of c-fos and other short-lived mRNAs". Mol. Cell. Biol. 20 (10): 3616–25. doi:10.1128/MCB.20.10.3616-3625.2000. PMC   85654 . PMID   10779351.
• Kannouche P, Mauffrey P, Pinon-Lataillade G, et al. (2000). "Molecular cloning and characterization of the human KIN17 cDNA encoding a component of the UVC response that is conserved among metazoans". Carcinogenesis. 21 (9): 1701–10. doi: 10.1093/carcin/21.9.1701 . PMID   10964102.
• Biard DS, Miccoli L, Despras E, et al. (2002). "Ionizing radiation triggers chromatin-bound kin17 complex formation in human cells". J. Biol. Chem. 277 (21): 19156–65. doi: 10.1074/jbc.M200321200 . PMID   11880372.
• Miccoli L, Biard DS, Créminon C, Angulo JF (2002). "Human kin17 protein directly interacts with the simian virus 40 large T antigen and inhibits DNA replication". Cancer Res. 62 (19): 5425–35. PMID   12359749.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Masson C, Menaa F, Pinon-Lataillade G, et al. (2003). "Global genome repair is required to activate KIN17, a UVC-responsive gene involved in DNA replication". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 616–21. Bibcode:2003PNAS..100..616M. doi: 10.1073/pnas.0236176100 . PMC   141045 . PMID   12525703.
• Despras E, Miccoli L, Créminon C, et al. (2003). "Depletion of KIN17, a human DNA replication protein, increases the radiosensitivity of RKO cells". Radiat. Res. 159 (6): 748–58. Bibcode:2003RadR..159..748D. doi:10.1667/0033-7587(2003)159[0748:DOKAHD]2.0.CO;2. ISSN   0033-7587. PMID   12751957. S2CID   10841640.
• Biard DS, Miccoli L, Despras E, et al. (2004). "Participation of kin17 protein in replication factories and in other DNA transactions mediated by high molecular weight nuclear complexes". Mol. Cancer Res. 1 (7): 519–31. PMID   12754299.
• Miccoli L, Biard DS, Frouin I, et al. (2003). "Selective interactions of human kin17 and RPA proteins with chromatin and the nuclear matrix in a DNA damage- and cell cycle-regulated manner". Nucleic Acids Res. 31 (14): 4162–75. doi:10.1093/nar/gkg459. PMC   165974 . PMID   12853634.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Miccoli L, Frouin I, Novac O, et al. (2005). "The human stress-activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins". Mol. Cell. Biol. 25 (9): 3814–30. doi:10.1128/MCB.25.9.3814-3830.2005. PMC   1084281 . PMID   15831485.
• le Maire A, Schiltz M, Braud S, et al. (2006). "Crystallization and halide phasing of the C-terminal domain of human KIN17". Acta Crystallographica Section F. 62 (Pt 3): 245–8. doi:10.1107/S174430910600409X. PMC   2197188 . PMID   16511313.
• le Maire A, Schiltz M, Stura EA, et al. (2007). "A tandem of SH3-like domains participates in RNA binding in KIN17, a human protein activated in response to genotoxics" (PDF). J. Mol. Biol. 364 (4): 764–76. doi:10.1016/j.jmb.2006.09.033. PMID   17045609.

External links

• Overview of all the structural information available in the PDB for UniProt : O60870 (DNA/RNA-binding protein KIN17) at the PDBe-KB .