KLC2

KLC2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3CEQ, 3EDT
Identifiers
Aliases	KLC2 , kinesin light chain 2
External IDs	OMIM: 611729 MGI: 107953 HomoloGene: 22468 GeneCards: KLC2
Gene location (Human)
Chr.	Chromosome 11 (human)
End	66,267,860 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	5,168,588 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; Brodmann area 9; ; endothelial cell; ; anterior pituitary; ; nucleus accumbens; ; amygdala; ; putamen; ; gastrocnemius muscle; ; caudate nucleus; ; hypothalamus;
	Top expressed in
	superior frontal gyrus; ; cerebellar cortex; ; pontine nuclei; ; superior colliculus; ; inferior colliculus; ; medulla oblongata; ; primary motor cortex; ; dorsal tegmental nucleus; ; dorsomedial hypothalamic nucleus; ; habenula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	microtubule motor activity ; protein binding ; kinesin binding ; cadherin binding ;
Cellular component	cytoplasm ; cytosol ; microtubule ; cytoskeleton ; membrane ; kinesin I complex ; kinesin complex ; nucleoplasm ; mitochondrion ; plasma membrane ; protein-containing complex ;
Biological process	microtubule-based movement ; antigen processing and presentation of exogenous peptide antigen via MHC class II ; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ;
	Sources:Amigo / QuickGO
Orthologs
	64837
	16594
	ENSG00000174996
	ENSMUSG00000024862
	Q9H0B6
	O88448
	NM_001134774 ; NM_001134775 ; NM_001134776 ; NM_022822 ; NM_001318734 Contents Interactions ; References ; Further reading ;
	NM_008451 ; NM_001369360 ; NM_001369361 ; NM_001369362
	NP_001128246 ; NP_001128247 ; NP_001128248 ; NP_001305663 ; NP_073733
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 04, 2024

Kinesin light chain 2 is a protein that in humans is encoded by the KLC2 gene.^[5]^[6]

Interactions

KLC2 has been shown to interact with MAPK8IP3 ^[7] and KIF5B.^[5]^[8]

Related Research Articles

<span class="mw-page-title-main">KIF5B</span> Protein-coding gene in the species Homo sapiens

Kinesin family member 5B (KIF5B) is a protein that in humans is encoded by the KIF5B gene. It is part of the kinesin family of motor proteins.

Coatomer subunit epsilon is a protein that in humans is encoded by the COPE gene.

Nuclear migration protein nudC is a protein that in humans is encoded by the NUDC gene.

Kinesin light chain 1 is a protein that in humans is encoded by the KLC1 gene.

MARCKS-related protein is a protein that in humans is encoded by the MARCKSL1 gene.

Ras-related protein Rab-5B is a protein that in humans is encoded by the RAB5B gene.

Spermatid perinuclear RNA-binding protein is a protein that in humans is encoded by the STRBP gene.

Myotubularin-related protein 6 is a protein that in humans is encoded by the MTMR6 gene.

Afadin- and alpha-actinin-binding protein is a protein that in humans is encoded by the SSX2IP gene. It has been shown that it functions together with WDR8 in centrosome maturation, ensuring proper spindle length and orientation. The SSX2IP-WDR8 complex additionally promotes ciliary vesicle docking during ciliogenesis.

Kinesin family member 5A is a protein that in humans is encoded by the KIF5A gene. It is part of the kinesin family of motor proteins.

Adaptin ear-binding coat-associated protein 2 is a protein that in humans is encoded by the NECAP2 gene.

Ergosterol biosynthetic protein 28 is a protein that in humans is encoded by the ERG28 gene.

Uncharacterized protein KIAA1267 is a protein that in humans is encoded by the KIAA1267 gene.

CTTNBP2 N-terminal-like protein is a protein that in humans is encoded by the CTTNBP2NL gene. It is a substrate for phosphorylation.

TIMMDC1 is a protein that in humans is encoded by the TIMMDC1 gene. It is a chaperone protein involved in constructing the membrane arm of mitochondrial Complex I. A frameshift mutation in an intron of this gene has been shown to cause failure to thrive, retardation of psychomotor development, infantile-onset hypotonia, and severe neurologic dysfunction. High expression of this gene has been associated with migration of lung cancer cells while depletion of the protein has been shown to affect regulation of apoptosis, the cell cycle, and cell migration.

Mitochondrial Rho GTPase 1 (MIRO1) is an enzyme that in humans is encoded by the RHOT1 gene on chromosome 17. As a Miro protein isoform, the protein facilitates mitochondrial transport by attaching the mitochondria to the motor/adaptor complex. Through its key role in mitochondrial transport, RHOT1 is involved in mitochondrial homeostasis and apoptosis, as well as Parkinson's disease (PD) and cancer.

Activating signal cointegrator 1 complex subunit 3 is a protein that in humans is encoded by the ASCC3 gene.

Synaptotagmin-13 is a protein that in humans is encoded by the SYT13 gene.

DEP domain-containing mTOR-interacting protein (DEPTOR) also known as DEP domain-containing protein 6 (DEPDC6) is a protein that in humans is encoded by the DEPTOR gene.

Zinc finger protein 34 is a protein that in humans is encoded by the ZNF34 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000174996 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024862 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Rahman A, Friedman DS, Goldstein LS (Jun 1998). "Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins". The Journal of Biological Chemistry. 273 (25): 15395–403. doi: 10.1074/jbc.273.25.15395 . PMID 9624122.
↑ "Entrez Gene: KLC2 kinesin light chain 2".
↑ Bowman AB, Kamal A, Ritchings BW, Philp AV, McGrail M, Gindhart JG, Goldstein LS (Nov 2000). "Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein". Cell. 103 (4): 583–94. doi: 10.1016/S0092-8674(00)00162-8 . PMID 11106729. S2CID 247102.
↑ Rahman A, Kamal A, Roberts EA, Goldstein LS (Sep 1999). "Defective kinesin heavy chain behavior in mouse kinesin light chain mutants". The Journal of Cell Biology. 146 (6): 1277–88. doi:10.1083/jcb.146.6.1277. PMC 2156125 . PMID 10491391.

Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948 . PMID 11076863.
Bowman AB, Kamal A, Ritchings BW, Philp AV, McGrail M, Gindhart JG, Goldstein LS (Nov 2000). "Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein". Cell. 103 (4): 583–94. doi: 10.1016/S0092-8674(00)00162-8 . PMID 11106729. S2CID 247102.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732 . PMID 11256614.
Newsome TP, Scaplehorn N, Way M (Oct 2004). "SRC mediates a switch from microtubule- to actin-based motility of vaccinia virus". Science. 306 (5693): 124–9. Bibcode:2004Sci...306..124N. doi:10.1126/science.1101509. PMID 15297625. S2CID 45392007.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.
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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000174996 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024862 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9624122-5] 1 2 Rahman A, Friedman DS, Goldstein LS (Jun 1998). "Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins". The Journal of Biological Chemistry. 273 (25): 15395–403. doi: 10.1074/jbc.273.25.15395 . PMID 9624122.

[entrez-6] "Entrez Gene: KLC2 kinesin light chain 2".

[pmid11106729-7] Bowman AB, Kamal A, Ritchings BW, Philp AV, McGrail M, Gindhart JG, Goldstein LS (Nov 2000). "Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein". Cell. 103 (4): 583–94. doi: 10.1016/S0092-8674(00)00162-8 . PMID 11106729. S2CID 247102.

[pmid10491391-8] Rahman A, Kamal A, Roberts EA, Goldstein LS (Sep 1999). "Defective kinesin heavy chain behavior in mouse kinesin light chain mutants". The Journal of Cell Biology. 146 (6): 1277–88. doi:10.1083/jcb.146.6.1277. PMC 2156125 . PMID 10491391.

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KLC2

Contents

Interactions

Related Research Articles

References

Further reading