MAPK8IP3

Last updated
MAPK8IP3
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MAPK8IP3 , JIP3, JSAP1, SYD2, syd, JIP-3, mitogen-activated protein kinase 8 interacting protein 3
External IDs OMIM: 605431; MGI: 1353598; HomoloGene: 22790; GeneCards: MAPK8IP3; OMA:MAPK8IP3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001040439
NM_015133
NM_001318852

RefSeq (protein)

NP_001035529
NP_001305781
NP_055948

Location (UCSC) Chr 16: 1.71 – 1.77 Mb Chr 17: 25.11 – 25.16 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

C-jun-amino-terminal kinase-interacting protein 3 is an enzyme that in humans is encoded by the MAPK8IP3 gene. [5] [6] [7]

Contents

The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport, possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [7]

Interactions

MAPK8IP3 has been shown to interact with ASK1, [8] C-Raf, [5] [9] PTK2, [10] MAPK10, [5] [6] [8] Mitogen-activated protein kinase 9, [5] [6] MAPK8, [5] [6] MAP2K1, [5] [9] KLC2, [11] MAP2K7, [6] [8] KLC1, [11] MAPK8IP2 [6] and MAP2K4. [5] [8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000138834 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024163 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 3 4 5 6 7 Ito M, Yoshioka K, Akechi M, Yamashita S, Takamatsu N, Sugiyama K, Hibi M, Nakabeppu Y, Shiba T, Yamamoto KI (November 1999). "JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway". Mol Cell Biol. 19 (11): 7539–48. doi:10.1128/mcb.19.11.7539. PMC   84763 . PMID   10523642.
  6. 1 2 3 4 5 6 Kelkar N, Gupta S, Dickens M, Davis RJ (February 2000). "Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3". Mol Cell Biol. 20 (3): 1030–43. doi:10.1128/MCB.20.3.1030-1043.2000. PMC   85220 . PMID   10629060.
  7. 1 2 "Entrez Gene: MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3".
  8. 1 2 3 4 Matsuura, Hiroshi; Nishitoh Hideki; Takeda Kohsuke; Matsuzawa Atsushi; Amagasa Teruo; Ito Michihiko; Yoshioka Katsuji; Ichijo Hidenori (October 2002). "Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade". J. Biol. Chem. 277 (43). United States: 40703–9. doi: 10.1074/jbc.M202004200 . hdl: 2297/2692 . ISSN   0021-9258. PMID   12189133.
  9. 1 2 Kuboki, Y; Ito M; Takamatsu N; Yamamoto K I; Shiba T; Yoshioka K (December 2000). "A scaffold protein in the c-Jun NH2-terminal kinase signaling pathways suppresses the extracellular signal-regulated kinase signaling pathways". J. Biol. Chem. 275 (51). UNITED STATES: 39815–8. doi: 10.1074/jbc.C000403200 . ISSN   0021-9258. PMID   11044439.
  10. Takino, Takahisa; Yoshioka Katsuji; Miyamori Hisashi; Yamada Kenneth M; Sato Hiroshi (September 2002). "A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated". Oncogene. 21 (42). England: 6488–97. doi: 10.1038/sj.onc.1205840 . hdl: 2297/2669 . ISSN   0950-9232. PMID   12226752.
  11. 1 2 Bowman, A B; Kamal A; Ritchings B W; Philp A V; McGrail M; Gindhart J G; Goldstein L S (November 2000). "Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein". Cell. 103 (4). UNITED STATES: 583–94. doi: 10.1016/S0092-8674(00)00162-8 . ISSN   0092-8674. PMID   11106729. S2CID   247102.

Further reading