KLC3

KLC3
Identifiers
Aliases	KLC3 , KLC2, KLC2L, KLCt, KNS2B, kinesin light chain 3
External IDs	OMIM: 601334 MGI: 1277971 HomoloGene: 14899 GeneCards: KLC3
Gene location (Human)
Chr.	Chromosome 19 (human)
End	45,351,520 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	19,138,029 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; amniotic fluid; ; superficial temporal artery; ; vulva; ; external globus pallidus; ; oral cavity; ; nipple; ; vena cava; ; cardia; ; body of tongue;
	Top expressed in
	lip; ; esophagus; ; hair follicle; ; skin of back; ; skin of abdomen; ; olfactory epithelium; ; seminiferous tubule; ; retinal pigment epithelium; ; cornea; ; submandibular gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	microtubule binding ; microtubule motor activity ; protein binding ; kinesin binding ;
Cellular component	cytoplasm ; neuron projection ; motile cilium ; microtubule ; cytoskeleton ; kinesin complex ; ciliary rootlet ;
Biological process	axo-dendritic transport ;
	Sources:Amigo / QuickGO
Orthologs
	147700
	232943
	ENSG00000104892
	ENSMUSG00000040714
	Q6P597
	Q91W40
	NM_145275 ; NM_177417
	NM_001286038 ; NM_001286039 ; NM_146182
	NP_803136
	NP_001272967 ; NP_001272968 ; NP_666294 ; NP_001390614
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 04, 2024

Kinesin light chain 3 is a protein that in humans is encoded by the KLC3 gene.^[5]

Function

This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain (KHC) and two kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria.^[5]

Interactions

KLC3 has been shown to interact with YWHAH.^[6]

Related Research Articles

A kinesin is a protein belonging to a class of motor proteins found in eukaryotic cells. Kinesins move along microtubule (MT) filaments and are powered by the hydrolysis of adenosine triphosphate (ATP). The active movement of kinesins supports several cellular functions including mitosis, meiosis and transport of cellular cargo, such as in axonal transport, and intraflagellar transport. Most kinesins walk towards the plus end of a microtubule, which, in most cells, entails transporting cargo such as protein and membrane components from the center of the cell towards the periphery. This form of transport is known as anterograde transport. In contrast, dyneins are motor proteins that move toward the minus end of a microtubule in retrograde transport.

14-3-3 protein eta also referred to as 14-3-3η is a protein that in humans is encoded by the YWHAH gene.

Dynein light chain 1, cytoplasmic is a protein that in humans is encoded by the DYNLL1 gene.

<span class="mw-page-title-main">KIF5B</span> Protein-coding gene in the species Homo sapiens

Kinesin family member 5B (KIF5B) is a protein that in humans is encoded by the KIF5B gene. It is part of the kinesin family of motor proteins.

<span class="mw-page-title-main">KIF4A</span> Protein-coding gene in the species Homo sapiens

Kinesin family member 4A is a protein that in humans is encoded by the KIF4A gene.

Kinesin light chain 1 is a protein that in humans is encoded by the KLC1 gene.

F-actin-capping protein subunit alpha-1 is a protein that in humans is encoded by the CAPZA1 gene.

Kinesin-like protein KIF3A is a protein that in humans is encoded by the KIF3A gene.

Spermatid perinuclear RNA-binding protein is a protein that in humans is encoded by the STRBP gene.

Kinesin light chain 2 is a protein that in humans is encoded by the KLC2 gene.

<span class="mw-page-title-main">KIF3B</span> Protein-coding gene in the species Homo sapiens

Kinesin-like protein KIF3B is a protein that in humans is encoded by the KIF3B gene. KIF3B is an N-type protein that complexes with two other kinesin proteins to form two-headed anterograde motors. First, KIF3B forms a heterodimer with KIF3A ; (KIF3A/3B), that is membrane-bound and has ATPase activity. Then KIFAP3 binds to the tail domain to form a heterotrimeric motor. This motor has a plus end-directed microtubule sliding activity that exhibits a velocity of ~0.3 μm/s a. There are 14 kinesin protein families in the kinesin superfamily and KIF3B is part of the Kinesin-2 family, of kinesins that can all form heterotrimeric complexes. Expression of the three motor subunits is ubiquitous. The KIG3A/3B/KAP3 motors can transport 90 to 160 nm in diameter organelles.

Cytoplasmic dynein 1 intermediate chain 1 is a protein that in humans is encoded by the DYNC1I1 gene.

Kinesin family member 5A is a protein that in humans is encoded by the KIF5A gene. It is part of the kinesin family of motor proteins.

Outer dense fiber protein 1 is a protein that in humans is encoded by the ODF1 gene.

Ensconsin is a protein that in humans is encoded by the MAP7 gene.

<span class="mw-page-title-main">KIF18A</span> Protein-coding gene in the species Homo sapiens

Kinesin family member KIF18A is a human protein encoded by the KIF18A gene. It is part of the kinesin family of motor proteins.

Kinesin heavy chain isoform 5C is a protein that in humans is encoded by the KIF5C gene. It is part of the kinesin family of motor proteins.

KIF1-binding protein, also known as Kinesin binding protein(KBP), is a protein that in humans is encoded by the KIAA1279 gene. The interaction of KBP with Kif15 is necessary for the localization of Kif15 to the microtubule plus-end at the spindle equator. Interaction between Kif15 and KBP is essential for the perfect alignment of chromosomes at the metaphase plate, and any defect in their interaction leads to delay in chromosomal alignment during mitosis. Anything that perturb the interaction of KBP and Kif15 can block the cells at mitosis, and hence it can be therapeutically used to control Kif15 upregulated cancer cells.

Kinesin-like protein KIF2A is a protein that in humans is encoded by the KIF2A gene. In mice, KIF2A is essential for proper neurogenesis and deficiency of KIF2A in mature neurons results in the loss of those neurons.

<span class="mw-page-title-main">KIF15</span> Protein-coding gene in the species Homo sapiens

Kinesin family member 15 is a protein that in humans is encoded by the KIF15 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000104892 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040714 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: KLC3 kinesin light chain 3".
↑ Ichimura T, Wakamiya-Tsuruta A, Itagaki C, Taoka M, Hayano T, Natsume T, Isobe T (Apr 2002). "Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein". Biochemistry. 41 (17): 5566–72. doi:10.1021/bi015946f. PMID 11969417.

Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.
Zhang Y, Oko R, van der Hoorn FA (Nov 2004). "Rat kinesin light chain 3 associates with spermatid mitochondria". Developmental Biology. 275 (1): 23–33. doi:10.1016/j.ydbio.2004.07.014. PMC 3138780 . PMID 15464570.
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi: 10.1016/j.cub.2004.07.051 . PMID 15324660. S2CID 2371325.
Bhullar B, Zhang Y, Junco A, Oko R, van der Hoorn FA (May 2003). "Association of kinesin light chain with outer dense fibers in a microtubule-independent fashion". The Journal of Biological Chemistry. 278 (18): 16159–68. doi: 10.1074/jbc.M213126200 . PMC 3178653 . PMID 12594206.
Yang J, Liu X, Yue G, Adamian M, Bulgakov O, Li T (Nov 2002). "Rootletin, a novel coiled-coil protein, is a structural component of the ciliary rootlet". The Journal of Cell Biology. 159 (3): 431–40. doi:10.1083/jcb.200207153. PMC 2173070 . PMID 12427867.
Ichimura T, Wakamiya-Tsuruta A, Itagaki C, Taoka M, Hayano T, Natsume T, Isobe T (Apr 2002). "Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein". Biochemistry. 41 (17): 5566–72. doi:10.1021/bi015946f. PMID 11969417.
Junco A, Bhullar B, Tarnasky HA, van der Hoorn FA (May 2001). "Kinesin light-chain KLC3 expression in testis is restricted to spermatids". Biology of Reproduction. 64 (5): 1320–30. doi:10.1095/biolreprod64.5.1320. PMC 3161965 . PMID 11319135.
Rahman A, Kamal A, Roberts EA, Goldstein LS (Sep 1999). "Defective kinesin heavy chain behavior in mouse kinesin light chain mutants". The Journal of Cell Biology. 146 (6): 1277–88. doi:10.1083/jcb.146.6.1277. PMC 2156125 . PMID 10491391.
Rahman A, Friedman DS, Goldstein LS (Jun 1998). "Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins". The Journal of Biological Chemistry. 273 (25): 15395–403. doi: 10.1074/jbc.273.25.15395 . PMID 9624122.
Lamerdin JE, Stilwagen SA, Ramirez MH, Stubbs L, Carrano AV (Jun 1996). "Sequence analysis of the ERCC2 gene regions in human, mouse, and hamster reveals three linked genes". Genomics. 34 (3): 399–409. doi:10.1006/geno.1996.0303. PMID 8786141.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000104892 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040714 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: KLC3 kinesin light chain 3".

[pmid11969417-6] Ichimura T, Wakamiya-Tsuruta A, Itagaki C, Taoka M, Hayano T, Natsume T, Isobe T (Apr 2002). "Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein". Biochemistry. 41 (17): 5566–72. doi:10.1021/bi015946f. PMID 11969417.

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KLC3

Contents

Function

Interactions

Related Research Articles

References

Further reading