KLHDC3

KLHDC3
Identifiers
Aliases	KLHDC3 , PEAS, dJ20C7.3, kelch domain containing 3
External IDs	OMIM: 611248 MGI: 2651568 HomoloGene: 14290 GeneCards: KLHDC3
Gene location (Human)
Chr.	Chromosome 6 (human)
End	43,021,298 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	46,991,840 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; cerebellar hemisphere; ; Brodmann area 9; ; triceps brachii muscle; ; nucleus accumbens; ; amygdala; ; cingulate gyrus; ; caudate nucleus; ; putamen; ; ganglionic eminence;
	Top expressed in
	seminiferous tubule; ; superior frontal gyrus; ; right ventricle; ; yolk sac; ; temporal muscle; ; ankle; ; secondary oocyte; ; digastric muscle; ; cerebellar cortex; ; skeletal muscle tissue;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	chromatin binding ; protein binding ;
Cellular component	cytoplasm ; cytosol ; nucleoplasm ;
Biological process	reciprocal meiotic recombination ; IRE1-mediated unfolded protein response ; meiosis ;
	Sources:Amigo / QuickGO
Orthologs
	116138
	71765
	ENSG00000124702
	ENSMUSG00000063576
	Q9BQ90
	Q8VEM9
	NM_001242872 ; NM_057161
	NM_001163729 ; NM_027910
	NP_476502
	NP_001157201 ; NP_082186
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Kelch domain-containing protein 3 is a protein that in humans is encoded by the KLHDC3 gene.^[5]^[6]

The protein encoded by this gene contains six repeated kelch motifs that are structurally similar to recombination activating gene 2 (RAG2), a protein involved in the activation of the V(D)J recombination. This gene is found to express specifically in testis. Its expression in pachytene spermatocytes is localized to cytoplasm and meiotic chromatin, which suggests that this gene may be involved in meiotic recombination.^[6]

Related Research Articles

Spermatocytes are a type of male gametocyte in animals. They derive from immature germ cells called spermatogonia. They are found in the testis, in a structure known as the seminiferous tubules. There are two types of spermatocytes, primary and secondary spermatocytes. Primary and secondary spermatocytes are formed through the process of spermatocytogenesis.

Fanconi anemia group D2 protein is a protein that in humans is encoded by the FANCD2 gene. The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ, FANCL, FANCM, FANCN and FANCO.

Nuclear autoantigenic sperm protein is a protein that in humans is encoded by the NASP gene. Multiple isoforms are encoded by transcript variants of this gene.

AT-rich interactive domain-containing protein 1B is a protein that in humans is encoded by the ARID1B gene. ARID1B is a component of the human SWI/SNF chromatin remodeling complex.

Zinc finger Y-chromosomal protein is a protein that in humans is encoded by the ZFY gene of the Y chromosome.

Histone H2A type 3 is a protein that in humans is encoded by the HIST3H2A gene.

Histone H2B type 1-A is a protein that in humans is encoded by the HIST1H2BA gene.

DNA-binding protein RFX2 is a protein that in humans is encoded by the RFX2 gene.

Cytoplasmic dynein 2 heavy chain 1 is a protein that in humans is encoded by the DYNC2H1 gene.

Calmegin, also known as CLGN, is a protein which in humans is encoded by the CLGN gene. Calmegin is also present in other animals including mice.

DNA repair and recombination protein RAD54B is a protein that in humans is encoded by the RAD54B gene.

Transcription factor SOX-8 is a protein that in humans is encoded by the SOX8 gene.

Serine/threonine-protein kinase MAK is an enzyme that in humans is encoded by the MAK gene.

Kelch-like protein 20 is a protein that in humans is encoded by the KLHL20 gene.

Transcriptional repressor CTCFL also known as BORIS is a protein that in humans is encoded by the CTCFL gene.

Bromodomain testis-specific protein is a protein that in humans is encoded by the BRDT gene. It is a member of the Bromodomain and Extra-terminal motif (BET) protein family.

HORMA domain-containing protein 1 (HORMAD1) also known as cancer/testis antigen 46 (CT46) is a protein that in humans is encoded by the HORMAD1 gene.

DNA replication licensing factor MCM8 is a protein that in humans is encoded by the MCM8 gene.

The meiotic recombination checkpoint monitors meiotic recombination during meiosis, and blocks the entry into metaphase I if recombination is not efficiently processed.

Tektin-1 is a protein that in humans is encoded by the TEKT1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000124702 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000063576 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ohinata Y, Sutou S, Kondo M, Takahashi T, Mitsui Y (Nov 2002). "Male-enhanced antigen-1 gene flanked by two overlapping genes is expressed in late spermatogenesis". Biol Reprod. 67 (6): 1824–31. doi: 10.1095/biolreprod.101.002550 . PMID 12444059.
1 2 "Entrez Gene: KLHDC3 kelch domain containing 3".

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID 14574404.
Ohinata Y, Sutou S, Mitsui Y (2003). "Peas-Mea1-Ppp2r5d overlapping gene complex: a transposon mediated-gene formation in mammals". DNA Res. 10 (2): 79–84. doi: 10.1093/dnares/10.2.79 . PMID 12755172.
Ohinata Y, Sutou S, Mitsui Y (2003). "A novel testis-specific RAG2-like protein, Peas: its expression in pachytene spermatocyte cytoplasm and meiotic chromatin". FEBS Lett. 537 (1–3): 1–5. doi:10.1016/S0014-5793(03)00036-X. PMID 12606021. S2CID 45307604.
Hermey G, Keat SJ, Madsen P, et al. (2003). "Characterization of sorCS1, an alternatively spliced receptor with completely different cytoplasmic domains that mediate different trafficking in cells". J. Biol. Chem. 278 (9): 7390–6. doi: 10.1074/jbc.M210851200 . PMID 12482870.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000124702 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000063576 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12444059-5] Ohinata Y, Sutou S, Kondo M, Takahashi T, Mitsui Y (Nov 2002). "Male-enhanced antigen-1 gene flanked by two overlapping genes is expressed in late spermatogenesis". Biol Reprod. 67 (6): 1824–31. doi: 10.1095/biolreprod.101.002550 . PMID 12444059.

[entrez-6] 1 2 "Entrez Gene: KLHDC3 kelch domain containing 3".

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KLHDC3

Related Research Articles

References

Further reading