Kristi Kiick

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Kristi Kiick
Professor Kristi Kiick.jpg
Kristi Kiick at the University of York in January 2020
Born
Kristi Lynn Kiick

1967 (age 5556) [1]
Alma mater University of Delaware (BSc)
University of Georgia (MSc)
University of Massachusetts Amherst (MSc, PhD)
Awards National Science Foundation CAREER Award (2003)
Fulbright Scholar (2019)
Scientific career
Fields Biomaterials [2]
Institutions University of Delaware
Thesis Expanding the scope of templated macromolecular synthesis in vivo: The incorporation of methionine analogues into proteins in vivo by altering the methionyl-tRNA synthetase activity of a bacterial expression host  (2001)
Doctoral advisor David A. Tirrell
Website sites.udel.edu/kiickgroup

Kristi Lynn Kiick is the Blue and Gold Distinguished Professor of Materials Science and Engineering at the University of Delaware. [2] She studies polymers, biomaterials and hydrogels for drug delivery and regenerative medicine. She is a Fellow of the American Chemical Society, the American Institute for Medical and Biological Engineering, and of the National Academy of Inventors. She served for nearly eight years as the deputy dean of the college of engineering at the University of Delaware.

Contents

Early life and education

Kiick first became interested in a career in the chemical sciences when she was at high school. [3] She studied chemistry at the University of Delaware, from which she graduated summa cum laude as a Eugene du Pont memorial distinguished scholar. [4] She was a Master's student at the University of Georgia, where she was awarded a National Science Foundation (NSF) predoctoral fellowship, and joined Kimberly-Clark as a research scientist in 1992. [4] Kiick returned to academia for a second master's degree in polymer science and engineering at the University of Massachusetts Amherst. [4] She completed her doctoral research at the California Institute of Technology, as a National Defense Science and Engineering Graduate (NDSEG) fellow. [4] She completed her PhD from the University of Massachusetts Amherst on templated macromolecular synthesis in 2001 under the supervision of David A. Tirrell, [5] prior to starting her faculty position at the University of Delaware in 2001.

Research and career

Kiick designs polymer nanostructures for targeted therapies and hydrogel matrices for regenerative medicine. [6] She makes use of biomimetic self-assembly, bioconjugation and biosynthesis. [7] In particular, Kiick has worked on polymer-peptide macromolecular structures that can engage cellular targets. These include the use of polyethylene glycol (PEG) in click chemistry to form hydrogels that degrade selectively in response to molecules present in tissues and extracellular matrix. [7] Kiick has shown it is possible to selectively release small molecule cargo with a tuned release for applications in targeted drug-delivery and vascular grafts. [7] She has developed resilin-like polypeptides (RLP), elastomeric materials that can be cross-linked using small molecules, as well as hydrogels that contain nanoparticles for targeting tumors and inflammatory conditions. [6] Resilin is a primary elastomeric protein that is found in insects, and helps them to jump long distances and produce sound. [8]

She joined the faculty at the University of Delaware in 2001, and earned the rank of associate professor in 2007. In 2011 Kiick was promoted to the rank of professor of materials science and engineering and also named deputy dean of the University of Delaware’s college of engineering. [9] In 2019-2020 she was awarded a Leverhulme Visiting Professorship from the Leverhulme Trust and a Fulbright Scholarship from the Fulbright Program to the University of Nottingham, to develop protocols for fabricating bioelastomeric materials. [10] [11]

Awards and honours

Her awards and honours include:

Selected publications

Her publications include:

Personal life

Kiick is married with two children. [3]

Related Research Articles

<span class="mw-page-title-main">Resilin</span> Insect protein

Resilin is an elastomeric protein found in many insects and other arthropods. It provides soft rubber-elasticity to mechanically active organs and tissue; for example, it enables insects of many species to jump or pivot their wings efficiently. Resilin was first discovered by Torkel Weis-Fogh in locust wing-hinges.

<span class="mw-page-title-main">Nicholas A. Peppas</span> Greek chemical and biomedical engineer (b. 1948)

Nicholas (Nikolaos) A. Peppas is a chemical and biomedical engineer whose leadership in biomaterials science and engineering, drug delivery, bionanotechnology, pharmaceutical sciences, chemical and polymer engineering has provided seminal foundations based on the physics and mathematical theories of nanoscale, macromolecular processes and drug/protein transport and has led to numerous biomedical products or devices.

<span class="mw-page-title-main">Otto Vogl</span>

Otto Vogl was an American chemist, polymer scientist, and educator.

Kristi S. Anseth is the Tisone Distinguished Professor of Chemical and Biological Engineering, an Associate Professor of Surgery, and a Howard Hughes Medical Investigator at the University of Colorado at Boulder. Her main research interests are the design of synthetic biomaterials using hydrogels, tissue engineering, and regenerative medicine.

<span class="mw-page-title-main">Jindřich Kopeček</span> American chemist (born 1940)

Jindřich Henry Kopeček was born in Strakonice, Czech Republic, as the son of Jan and Herta Zita (Krombholz) Kopeček. He is distinguished professor of pharmaceutical chemistry and distinguished professor of biomedical engineering at the University of Utah in Salt Lake City, Utah. Kopeček is also an honorary professor at Sichuan University in Chengdu, China. His research focuses on biorecognition of macromolecules, bioconjugate chemistry, drug delivery systems, self-assembled biomaterials, and drug-free macromolecular therapeutics.

David A. Tirrell is an American chemist and the Ross McCollum-William H. Corcoran Professor and professor of chemistry and chemical engineering at the California Institute of Technology (Caltech). A pioneer in the areas of polymer synthesis and protein biosynthesis, his research has a wide range of applications, including coatings, adhesion, lubrication, bioengineering and biomedical intervention. From 2012 to 2018, Tirrell was the director of the Beckman Institute at Caltech. As of 2017, he serves as Caltech's Provost. He is one of very few American scientists to have been elected to all three branches of the United States National Academies: the National Academy of Sciences (2006), the National Academy of Engineering (2008), and the Institute of Medicine (2011). He was elected a Member of the American Philosophical Society in 2019.

<span class="mw-page-title-main">Edward Wilson Merrill</span> American biomaterials scientist (1923–2020)

Edward Wilson Merrill was an American biomaterials scientist. He was one of the founders of bioengineering, and specifically the biomedical engineering field it developed from chemical engineering. Merrill was born to Edward Clifton Merrill (1881–1949), a chemical engineer and chief chemist of the United Drug Company (Rexall) and Gertrude Wilson (1895–1978).

Nanocomposite hydrogels are nanomaterial-filled, hydrated, polymeric networks that exhibit higher elasticity and strength relative to traditionally made hydrogels. A range of natural and synthetic polymers are used to design nanocomposite network. By controlling the interactions between nanoparticles and polymer chains, a range of physical, chemical, and biological properties can be engineered. The combination of organic (polymer) and inorganic (clay) structure gives these hydrogels improved physical, chemical, electrical, biological, and swelling/de-swelling properties that cannot be achieved by either material alone. Inspired by flexible biological tissues, researchers incorporate carbon-based, polymeric, ceramic and/or metallic nanomaterials to give these hydrogels superior characteristics like optical properties and stimulus-sensitivity which can potentially be very helpful to medical and mechanical fields.

<span class="mw-page-title-main">Eugenia Kumacheva</span> Canadian chemist

Eugenia Kumacheva is a University Professor and Distinguished Professor of Chemistry at the University of Toronto. Her research interests span across the fields of fundamental and applied polymers science, nanotechnology, microfluidics, and interface chemistry. She was awarded the L'Oréal-UNESCO Awards for Women in Science in 2008 "for the design and development of new materials with many applications including targeted drug delivery for cancer treatments and materials for high density optical data storage". In 2011, she published a book on the Microfluidic Reactors for Polymer Particles co-authored with Piotr Garstecki. She is Canadian Research Chair in Advanced Polymer Materials. She is Fellow of the Royal Society (FRS) and a Fellow of the Royal Society of Canada (FRSC).

<span class="mw-page-title-main">Matthew Tirrell</span> American chemical engineer (born 1950)

Matthew V. Tirrell is an American chemical engineer. In 2011 he became the founding Pritzker Director and dean of the Institute for Molecular Engineering (IME) at the University of Chicago, in addition to serving as senior scientist at Argonne National Laboratory. Tirrell's research specializes in the manipulation and measurement of polymer surface properties, polyelectrolyte complexation, and biomedical nanoparticles.

<span class="mw-page-title-main">Jin Kim Montclare</span> Korean American biomolecular engineer

Jin Kim Montclare is a Professor of Chemical and Biomolecular Engineering at New York University. She creates novel proteins that can be used in drug delivery, tissue regeneration and as medical treatment. She is a 2019 AAAS Leshner Leadership Fellow and has been inducted to the AIMBE College of Fellows.

Ka Yee Christina Lee is Executive Vice President for Strategic Initiatives and the David Lee Shillinglaw Distinguished Service Professor in the Department of Chemistry University of Chicago. She works on membrane biophysics, including protein–lipid interactions, Alzheimer's disease and respiratory distress syndrome. She is a Fellow of the American Institute for Medical and Biological Engineering and American Physical Society.

Jodie L. Lutkenhaus is a Professor of Chemical Engineering at Texas A&M University who develops redox active polymers for energy storage and smart coatings. In 2019 Lutkenhaus and Karen L. Wooley demonstrated the world's first biodegradable peptide battery. Lutkenhaus is a World Economic Forum Young Scientist.

<span class="mw-page-title-main">Heather Maynard</span> American chemist

Heather D. Maynard is the Dr Myung Ki Hong Professor in Polymer Science at the University of California, Los Angeles. She works on protein-polymer conjugates and polymeric drugs. Maynard is a Fellow of the Royal Society of Chemistry and the American Association for the Advancement of Science.

<span class="mw-page-title-main">LaShanda Korley</span> Materials engineer and researcher

LaShanda Teresa James Korley is a Distinguished Professor of Materials Science at the University of Delaware and an expert in soft matter, polymers, and nature-inspired materials. On a larger scale, Korley is also working on developing strategies and technologies to prevent plastic waste in landfills and oceans by upcycling plastic waste to more valuable products. She leads such efforts through the Center for Plastics Innovation, the Center for Research in Soft Matter and Polymers, and also the Center for Hybrid, Active, and Responsive Materials (CHARM). Korley was awarded the 2019 National Organization for the Professional Advancement of Black Chemists and Chemical Engineers Lloyd N. Ferguson Young Scientist Award for Excellence in Research.

<span class="mw-page-title-main">Thomas H. Epps III</span> American chemist

Thomas H. Epps, III is an American chemist and the Thomas & Kipp Gutshall Professor of Chemical & Biomolecular Engineering at the University of Delaware. He has a joint appointment in Materials Science & Engineering, and an affiliated appointment in Biomedical Engineering. He serves as the director of the Center for Research in Soft Matter & Polymers, the director of the Center for Hybrid, Active, and Responsive Materials, and the co-director of the Center for Plastics Innovations. His research considers the design, synthesis, characterization, and application of nanostructure-containing polymers related to biobased materials, drug delivery, alternative energy (batteries), nanotemplating, and composite-based personal-protective equipment. He is also the co-founder of Lignolix, which is focused on the valorization of biomass waste.

Millicent Sullivan is an American chemical engineer and the Alvin B. & Julie O. Stiles Professor of Chemical & Biomolecular Engineering and department chair at the University of Delaware. She is a Fellow of the American Institute for Medical and Biological Engineering. Her research considers the development of polymeric materials for targeted drug delivery and the mechanisms that underpin cell – drug interactions.

Linda Jean Broadbelt is an American chemical engineer who is the Sarah Rebecca Roland Professor and associate dean for research of the McCormick School of Engineering and Applied Science at Northwestern University. Her research considers kinetics modeling, polymerization and catalysis.

Elizabeth Cosgriff-Hernandez is an American biomedical engineer who is a professor at the University of Texas at Austin. Her work involves the development of polymeric biomaterials for medical devices and tissue regeneration. She also serves on the scientific advisory board of ECM Biosurgery and as a consultant to several companies on biostability evaluation of medical devices. Cosgriff-Hernandez is an associate editor of the Journal of Materials Chemistry B and Fellow of the International Union of Societies for Biomaterials Science and Engineering, Biomedical Engineering Society, Royal Society of Chemistry, and the American Institute for Medical and Biological Engineering.

Tatiana Segura is an American biomedical engineer who is a professor at Duke University. Her research considers biomedical engineering solutions to promote cell growth. She was elected Fellow of the American Institute for Medical and Biological Engineering in 2017 and awarded the Acta Biomaterialia Silver Medal in 2021.

References

  1. Kristi Kiick at Library of Congress
  2. 1 2 Kristi Kiick publications indexed by Google Scholar OOjs UI icon edit-ltr-progressive.svg
  3. 1 2 "Author of the Week: Prof. Kristi L. Kiick – Polymer Chemistry Blog" . Retrieved 2020-01-22.
  4. 1 2 3 4 5 "Kristi Kiick honored for inventions | UDaily". udel.edu. Retrieved 2020-01-22.
  5. Kiick, Kristi Lynn (2001). Expanding the scope of templated macromolecular synthesis in vivo: The incorporation of methionine analogues into proteins in vivo by altering the methionyl-tRNA synthetase activity of a bacterial expression host. umass.edu (PhD thesis). University of Massachusetts Amherst. OCLC   931602667.
  6. 1 2 "Research | Kiick Research Group" . Retrieved 2020-01-22.
  7. 1 2 3 "Events: Institute of Bioengineering, Queen Mary University of London". bioengineering.qmul.ac.uk. Retrieved 2020-01-22.
  8. "Flexible Insect Protein Inspires Super Rubber". NPR.org. Retrieved 2020-01-22.
  9. "Kristi Kiick Kristi Kiick Named Deputy Dean of College of Engineering Effective Aug. 1". aimbe.org. Retrieved 2020-01-22.
  10. 1 2 "2019-20 American Fulbright Scholar Award grantees | US-UK Fulbright Commission". fulbright.org.uk. Retrieved 2020-01-22.
  11. "International scholarship in materials | UDaily". udel.edu. Retrieved 2020-01-22.
  12. "Department of Chemistry". chem.umn.edu. Retrieved 2020-01-22.
  13. "Awards & Honors | Women's Caucus" . Retrieved 2020-01-22.
  14. "POLY - What's New". old.polyacs.org. Retrieved 2020-01-22.
  15. "The Covestro Lecture Series | School of Polymer Science and Engineering | The University of Southern Mississippi". www.usm.edu. Retrieved 2020-01-22.