Kytococcus sedentarius | |
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Kytococcus sedentarius culture on Zobell's Marine Agar (Himedia) plate (quadrant streak plate). | |
Scientific classification | |
Domain: | Bacteria |
Phylum: | Actinomycetota |
Class: | Actinomycetia |
Order: | Micrococcales |
Family: | Kytococcaceae |
Genus: | Kytococcus |
Species: | K. sedentarius |
Binomial name | |
Kytococcus sedentarius | |
Type strain | |
ATCC 14392 [3] CCM 314 CCUG 33030 CIP 81.72 DSM 20547 IFO 15357 JCM 11482 LMG 14228 NBRC 15357 NCTC 11040 VKM B-1316 | |
Synonyms | |
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Kytococcus sedentarius is a marine dwelling Gram positive bacterium in the genus Kytococcus . [1] [2] It is known for the production of polyketide antibiotics as well as for its role as an opportunistic pathogen. It is strictly aerobic and can only grow when amino acids are provided.
It is found in tetrads, irregular clusters, and cubical packets of eight. It is catalase positive, oxidase positive, and exhibits strictly aerobic metabolism. Optimum growth temperature is 25–37 °C (77–99 °F). It is primarily isolated from human skin, and is one of the major causes of pitted keratolysis. [4] [5] It was once considered a species of the genus Micrococcus. [6]
The genome has been sequenced and contains 2,785,024 bp, [7] which is among the smallest for Actinomycetes, with a G+C content of 71.6%. This encodes 2639 protein coding genes.
Kytococcus sedentarius may pose a risk to human health through the development of pitted keratolysis, a skin condition characterized by the formation of small pits on the feet and occasionally on the palms, accompanied by potential foul odor and discomfort. [8] This condition typically arises when the feet are exposed to prolonged periods of warmth and humidity, creating an environment suitable to the growth of K. sedentarius and other bacteria. [9] While the process is not fully known, research suggests that K. sedentarius produces proteases, namely P1 and P2, which degrade various substrates found in human skin, including azocasein, insulin β-chain, and keratin. [10] This enzymatic breakdown of keratin, a major component of the skin's horny layers, [11] results in the signature pitted appearance observed in affected areas. Studies indicate that these proteases work best within a slightly acidic pH range of 6.3–6.9, [12] which is why it is important to maintain proper foot hygiene to prevent pitted keratolysis. Additionally, these enzymatic reactions can generate sulfur compounds such as thiols, sulfides, and thioesters, contributing to the foul odor associated with the condition. [13] Treatments for pitted keratolysis typically involve antibiotics aimed at eliminating K. sedentarius and associated bacteria. Commonly prescribed antibiotics include erythromycin, mupirocin, and clindamycin. Preventive measures include keeping the feet dry and using absorbent cotton socks to minimize moisture accumulation. [14]
While Kytococcus sedentarius is typically regarded as a harmless bacteria, rare instances of infection attributable to this K. sedentarius have been documented, particularly in individuals with compromised immune systems. One case involves a 79-year-old woman with type 2 diabetes and hypertension, who was diagnosed with infectious spondylitis. Upon surgical removal and analyzation of the infected tissue, K. sedentarius was identified as the causative agent. Although how K. sedentarius could have caused the infection is uncertain, it is likely that the breakage of skin barriers during invasive procedures, such as injection therapy, may have caused the bacteria to enter. [15] Another noteworthy case involves a 66-year-old woman with end-stage renal disease due to type 2 diabetes, who developed peritoneal dialysis-associated peritonitis attributed to Kytococcus sedentarius. This case highlights the potential for touch contamination in infections by Kytococcus sedentarius. [16] Another case involves a 55-year-old man with leukemia who developed hemorrhagic pneumonia likely caused by K. sedentarius after getting induction chemotherapy. It was likely that the chemo caused injuries in the mucosal barrier, which allowed the bacteria to penetrate the gut and reach the lungs through the bloodstreams. [17]
Peritonitis is inflammation of the localized or generalized peritoneum, the lining of the inner wall of the abdomen and cover of the abdominal organs. Symptoms may include severe pain, swelling of the abdomen, fever, or weight loss. One part or the entire abdomen may be tender. Complications may include shock and acute respiratory distress syndrome.
A plantar wart is a wart occurring on the bottom of the foot or toes. Its color is typically similar to that of the skin. Small black dots often occur on the surface. One or more may occur in an area. They may result in pain with pressure such that walking is difficult.
Cutibacterium acnes is the relatively slow-growing, typically aerotolerant anaerobic, gram-positive bacterium (rod) linked to the skin condition of acne; it can also cause chronic blepharitis and endophthalmitis, the latter particularly following intraocular surgery. Its genome has been sequenced and a study has shown several genes can generate enzymes for degrading skin and proteins that may be immunogenic.
Peritoneal dialysis (PD) is a type of dialysis that uses the peritoneum in a person's abdomen as the membrane through which fluid and dissolved substances are exchanged with the blood. It is used to remove excess fluid, correct electrolyte problems, and remove toxins in those with kidney failure. Peritoneal dialysis has better outcomes than hemodialysis during the first couple of years. Other benefits include greater flexibility and better tolerability in those with significant heart disease.
The stratum corneum is the outermost layer of the epidermis. Consisting of dead tissue, it protects underlying tissue from infection, dehydration, chemicals and mechanical stress. It is composed of 15–20 layers of flattened cells with no nuclei and cell organelles.
A boil, also called a furuncle, is a deep folliculitis, which is an infection of the hair follicle. It is most commonly caused by infection by the bacterium Staphylococcus aureus, resulting in a painful swollen area on the skin caused by an accumulation of pus and dead tissue. Boils are therefore basically pus-filled nodules. Individual boils clustered together are called carbuncles. Most human infections are caused by coagulase-positive S. aureus strains, notable for the bacteria's ability to produce coagulase, an enzyme that can clot blood. Almost any organ system can be infected by S. aureus.
Caulobacter is a genus of Gram-negative bacteria in the class Alphaproteobacteria. Its best-known member is Caulobacter crescentus, an organism ubiquitous in freshwater lakes and rivers; many members of the genus are specialized to oligotrophic environments.
A comedo is a clogged hair follicle (pore) in the skin. Keratin combines with oil to block the follicle. A comedo can be open (blackhead) or closed by skin (whitehead) and occur with or without acne. The word "comedo" comes from the Latin comedere, meaning "to eat up", and was historically used to describe parasitic worms; in modern medical terminology, it is used to suggest the worm-like appearance of the expressed material.
Staphylococcus epidermidis is a Gram-positive bacterium, and one of over 40 species belonging to the genus Staphylococcus. It is part of the normal human microbiota, typically the skin microbiota, and less commonly the mucosal microbiota and also found in marine sponges. It is a facultative anaerobic bacteria. Although S. epidermidis is not usually pathogenic, patients with compromised immune systems are at risk of developing infection. These infections are generally hospital-acquired. S. epidermidis is a particular concern for people with catheters or other surgical implants because it is known to form biofilms that grow on these devices. Being part of the normal skin microbiota, S. epidermidis is a frequent contaminant of specimens sent to the diagnostic laboratory.
Erythrasma is a superficial skin infection that causes brown, scaly skin patches. It is caused by Corynebacterium minutissimum bacteria, a normal part of skin flora.
Micrococcus is a genus of bacteria in the Micrococcaceae family. Micrococcus occurs in a wide range of environments, including water, dust, and soil. Micrococci have Gram-positive spherical cells ranging from about 0.5 to 3 micrometers in diameter and typically appear in tetrads. They are catalase positive, oxidase positive, indole negative and citrate negative. Micrococcus has a substantial cell wall, which may comprise as much as 50% of the cell mass. The genome of Micrococcus is rich in guanine and cytosine (GC), typically exhibiting 65 to 75% GC-content. Micrococci often carry plasmids that provide the organism with useful traits.
Trichobacteriosis axillaris is a superficial bacterial colonization of the hair shafts in sweat gland–bearing areas, such as the armpits and the groin. It is a trivial disease of worldwide occurrence that is believed to be caused by the genus Corynebacteria.
Cheilitis is a medical condition characterized by inflammation of the lips. The inflammation may include the perioral skin, the vermilion border, or the labial mucosa. The skin and the vermilion border are more commonly involved, as the mucosa is less affected by inflammatory and allergic reactions.
Pitted keratolysis is a bacterial skin infection of the foot. The infection is characterized by craterlike pits on the sole of the feet and toes, particularly weight bearing areas.
Piedraia hortae is a superficial fungus that exists in the soils of tropical and subtropical environments and affects both sexes of all ages. The fungus grows very slowly, forming dark hyphae, which contain chlamydoconidia cells and black colonies when grown on agar. Piedraia hortae is a dermatophyte and causes a superficial fungal infection known as black piedra, which causes the formation of black nodules on the hair shaft and leads to progressive weakening of the hair. The infection usually infects hairs on the scalp and beard, but other varieties tend to grow on pubic hairs. The infection is usually treated with cutting or shaving of the hair and followed by the application of anti-fungal and topical agents. The fungus is used for cosmetic purposes to darken hair in some societies as a symbol of attractiveness.
Staphylococcus capitis is a coagulase-negative species (CoNS) of Staphylococcus. It is part of the normal flora of the skin of the human scalp, face, neck, scrotum, and ears and has been associated with prosthetic valve endocarditis, but is rarely associated with native valve infection.
Pasteurella canis is a Gram-negative, nonmotile, penicillin-sensitive coccobacillus of the family Pasteurellaceae. Bacteria from this family cause zoonotic infections in humans, which manifest themselves as skin or soft-tissue infections after an animal bite. It has been known to cause serious disease in immunocompromised patients.
Microsporum gallinae is a fungus of the genus Microsporum that causes dermatophytosis, commonly known as ringworm. Chickens represent the host population of Microsporum gallinae but its opportunistic nature allows it to enter other populations of fowl, mice, squirrels, cats, dogs and monkeys. Human cases of M. gallinae are rare, and usually mild, non-life-threatening superficial infections.
Kocuria is a genus of gram-positive bacteria. Kocuria is named after Miloslav Kocur, a Czech microbiologist. It has been found in the milk of water deer and reindeer. Cells are coccoid, resembling Staphylococcus and Micrococcus, and can group in pairs, chains, tetrads, cubical arrangements of eight, or irregular clusters. They have rigid cell walls and are either aerobic or facultative anaerobic. Kocuria can usually survive in mesophilic temperatures.
Kocuria varians is a gram-positive species of bacteria in the genus Kocuria. It has been isolated from milk, meat, skin, soil, and beach sand. It is 0.9 to 1.5 micrometers in diameter, and occurs in clusters, which can be up to 4 millimeters in diameter and are yellow. It is known to cause ocular infections, brain abscesses, and endophthalmitis.