LARP6

LARP6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MTF, 2MTG
Identifiers
Aliases	LARP6 , ACHN, La ribonucleoprotein domain family member 6, La ribonucleoprotein 6, translational regulator
External IDs	OMIM: 611300; MGI: 1914807; HomoloGene: 32408; GeneCards: LARP6; OMA:LARP6 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q23 Start 70,829,130 bp [1] End 70,854,157 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 B Start 60,620,272 bp [2] End 60,646,084 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in external globus pallidus inferior ganglion of vagus nerve gastric mucosa left testis lateral nuclear group of thalamus right testis C1 segment subthalamic nucleus inferior olivary nucleus pars reticulata Top expressed in pontine nuclei lateral geniculate nucleus superior colliculus anterior horn of spinal cord deep cerebellar nuclei dorsal tegmental nucleus lateral hypothalamus ventral tegmental area piriform cortex facial motor nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function RNA binding nucleic acid binding protein binding sequence-specific mRNA binding myosin binding RNA stem-loop binding mRNA 5'-UTR binding Cellular component cytoplasm nucleus polysome ribonucleoprotein complex Biological process RNA processing regulation of translation positive regulation of collagen biosynthetic process positive regulation of translation positive regulation of mRNA binding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55323 67557 Ensembl ENSG00000166173 ENSMUSG00000034839 UniProt Q9BRS8 Q8BN59 RefSeq (mRNA) NM_197958 NM_001286679 NM_018357 NM_026235 RefSeq (protein) NP_001273608 NP_060827 NP_932062 NP_080511 Location (UCSC) Chr 15: 70.83 – 70.85 Mb Chr 9: 60.62 – 60.65 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

La-related protein 6 also known as acheron or La ribonucleoprotein domain family member 6 (LARP6), is a protein that in humans is encoded by the LARP6 gene. ^[5]

Clinical relevance

In a recent genome-wide association study, LARP6 gene has been associated with fasting glucose traits, type 2 diabetes and obesity. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000166173 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034839 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: La ribonucleoprotein domain family".
6. Strawbridge RJ, Dupuis J, Prokopenko I, et al. (August 2011). "Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes". Diabetes. 60 (10): 2624–34. doi:10.2337/db11-0415. PMC   3178302 . PMID   21873549.

Further reading

• Cai L, Fritz D, Stefanovic L, Stefanovic B (2010). "Binding of LARP6 to the conserved 5' stem-loop regulates translation of mRNAs encoding type I collagen". J. Mol. Biol. 395 (2): 309–26. doi:10.1016/j.jmb.2009.11.020. PMC   2826804 . PMID   19917293.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983.
• Glenn HL, Wang Z, Schwartz LM (2010). "Acheron, a Lupus antigen family member, regulates integrin expression, adhesion, and motility in differentiating myoblasts". Am. J. Physiol., Cell Physiol. 298 (1): C46–55. doi:10.1152/ajpcell.00387.2009. PMC   2806151 . PMID   19889961.
• Valavanis C, Wang Z, Sun D, et al. (2007). "Acheron, a novel member of the Lupus Antigen family, is induced during the programmed cell death of skeletal muscles in the moth Manduca sexta". Gene. 393 (1–2): 101–9. doi:10.1016/j.gene.2007.01.033. PMC   2739619 . PMID   17383118.
• Barbe L, Lundberg E, Oksvold P, et al. (2008). "Toward a confocal subcellular atlas of the human proteome". Mol. Cell. Proteomics. 7 (3): 499–508. doi: 10.1074/mcp.M700325-MCP200 . PMID   18029348.