LARP6

LARP6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MTF, 2MTG
Identifiers
Aliases	LARP6 , ACHN, La ribonucleoprotein domain family member 6, La ribonucleoprotein 6, translational regulator
External IDs	OMIM: 611300 MGI: 1914807 HomoloGene: 32408 GeneCards: LARP6
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q23 Start 70,829,130 bp [1] End 70,854,157 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 B Start 60,712,989 bp [2] End 60,738,801 bp [2]
Gene ontology Molecular function • RNA binding • nucleic acid binding • GO:0001948 protein binding • sequence-specific mRNA binding • myosin binding • RNA stem-loop binding • mRNA 5'-UTR binding Cellular component • cytoplasm • nucleus • polysome • ribonucleoprotein complex Biological process • RNA processing • regulation of translation • positive regulation of collagen biosynthetic process • positive regulation of translation • positive regulation of mRNA binding Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55323	67557
Ensembl	ENSG00000166173	ENSMUSG00000034839
UniProt	Q9BRS8	Q8BN59
RefSeq (mRNA)	NM_197958 NM_001286679 NM_018357	NM_026235
RefSeq (protein)	NP_001273608 NP_060827 NP_932062	NP_080511
Location (UCSC)	Chr 15: 70.83 – 70.85 Mb	Chr 9: 60.71 – 60.74 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

La-related protein 6 also known as acheron or La ribonucleoprotein domain family member 6 (LARP6), is a protein that in humans is encoded by the LARP6 gene. ^[5]

Clinical relevance

In a recent genome-wide association study, LARP6 gene has been associated with fasting glucose traits, type 2 diabetes and obesity. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000166173 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034839 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: La ribonucleoprotein domain family".
6. Strawbridge RJ, Dupuis J, Prokopenko I, et al. (August 2011). "Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes". Diabetes. 60 (10): 2624–34. doi:10.2337/db11-0415. PMC   3178302 . PMID   21873549.

Further reading

• Cai L, Fritz D, Stefanovic L, Stefanovic B (2010). "Binding of LARP6 to the conserved 5' stem-loop regulates translation of mRNAs encoding type I collagen". J. Mol. Biol. 395 (2): 309–26. doi:10.1016/j.jmb.2009.11.020. PMC   2826804 . PMID   19917293.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983.
• Glenn HL, Wang Z, Schwartz LM (2010). "Acheron, a Lupus antigen family member, regulates integrin expression, adhesion, and motility in differentiating myoblasts". Am. J. Physiol., Cell Physiol. 298 (1): C46–55. doi:10.1152/ajpcell.00387.2009. PMC   2806151 . PMID   19889961.
• Valavanis C, Wang Z, Sun D, et al. (2007). "Acheron, a novel member of the Lupus Antigen family, is induced during the programmed cell death of skeletal muscles in the moth Manduca sexta". Gene. 393 (1–2): 101–9. doi:10.1016/j.gene.2007.01.033. PMC   2739619 . PMID   17383118.
• Barbe L, Lundberg E, Oksvold P, et al. (2008). "Toward a confocal subcellular atlas of the human proteome". Mol. Cell. Proteomics. 7 (3): 499–508. doi: 10.1074/mcp.M700325-MCP200 . PMID   18029348.