LCTL

LCTL
Identifiers
Aliases	LCTL , KLG, KLPH, lactase like
External IDs	OMIM: 617060 MGI: 2183549 HomoloGene: 70710 GeneCards: LCTL
Gene location (Human)
Chr.	Chromosome 15 (human)
End	66,565,979 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	64,138,118 bp
Gene ontology
Molecular function	• hydrolase activity, hydrolyzing O-glycosyl compounds ; • beta-glucosidase activity ;
Cellular component	• integral component of membrane ; • endoplasmic reticulum membrane ; • brush border ; • membrane ; • endoplasmic reticulum ;
Biological process	• glycosyl compound metabolic process ; • carbohydrate metabolic process ; • lens morphogenesis in camera-type eye ; • visual perception ; • response to stimulus ;
	Sources:Amigo / QuickGO
Orthologs
	197021
	235435
	ENSG00000188501
	ENSMUSG00000032401
	Q6UWM7
	Q8K1F9
	NM_001278562 ; NM_207338
	NM_145835
	NP_001265491 ; NP_997221
	NP_665834
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 20, 2020

Lactase-like is a protein that in humans is encoded by the LCTL gene.^[5] Lactase-like is a glycosidase enzyme.

Function

This gene encodes a member of family 1 glycosidases. Glycosidases are enzymes that hydrolyze glycosidic bonds and are classified into families based on primary amino acid sequence. Most members of family 1 have two conserved glutamic acid residues, which are required for enzymatic activity. The mouse ortholog of this protein has been characterized and has a domain structure of an N-terminal signal peptide, glycosidase domain, transmembrane domain, and a short cytoplasmic tail. It lacks one of the conserved glutamic acid residues important for catalysis, and its function remains to be determined (PMID: 12084582). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000188501 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032401 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Lactase-like" . Retrieved 2013-09-25.

LCTL

Contents

Function

Related Research Articles

References

Further reading