LGALS13

LGALS13
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1F87
Identifiers
Aliases	LGALS13 , GAL13, PLAC8, PP13, galectin 13
External IDs	OMIM: 608717; HomoloGene: 49329; GeneCards: LGALS13; OMA:LGALS13 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.2 Start 39,602,524 bp [1] End 39,607,474 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta thymus striated muscle tissue skeletal muscle tissue thigh muscle of thigh Cerebellum cerebellar cortex right hemisphere of cerebellum Hypothalamus n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function lysophospholipase activity protein binding carbohydrate binding Cellular component cytoplasm nuclear matrix nucleus Biological process phospholipid metabolic process positive regulation of T cell apoptotic process apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29124 n/a Ensembl ENSG00000105198 n/a UniProt Q9UHV8 n/a RefSeq (mRNA) NM_013268 n/a RefSeq (protein) NP_037400 n/a Location (UCSC) Chr 19: 39.6 – 39.61 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Placental protein 13 (PP13, also known as galectin-13) is a protein that in humans is encoded by the LGALS13 gene. ^{[3] [4]}

Structure and function

It is composed of two identical subunits which are held together by disulfide bonds. The monomer of this protein has structural similarity to several members of the beta-galactoside-binding S-type lectin family, but it could not bind beta-galactoside. This is because the ligand binding site is lack of key residue for binding beta-galactoside. ^[5] It is a galectin-like protein.

Galectin-13 has been shown to bind CD44, inhibiting membrane localization of SLC7A11 and promoting propagation of ferroptosis. ^[6]

Clinical significance

PP13 levels that are low in the first trimester of pregnancy confers a higher risk for developing pre-eclampsia later in pregnancy. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000105198 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Bohn H, Kraus W, Winckler W (Jul 1983). "Purification and characterization of two new soluble placental tissue proteins (PP13 and PP17)". Oncodevelopmental Biology and Medicine. 4 (5): 343–50. PMID   6856484.
4. Than NG, Sumegi B, Than GN, Berente Z, Bohn H (November 1999). "Isolation and sequence analysis of a cDNA encoding human placental tissue protein 13 (PP13), a new lysophospholipase, homologue of human eosinophil Charcot-Leyden Crystal protein". Placenta. 20 (8): 703–10. doi:10.1053/plac.1999.0436. PMID   10527825.
5. Su J, Wang Y, Si Y, Gao J, Song C, Cui L, Wu R, Tai G, Zhou Y (January 2018). "Galectin-13, a different prototype galectin, does not bind β-galacto-sides and forms dimers via intermolecular disulfide bridges between Cys-136 and Cys-138". Scientific Reports. 8 (1): 980. Bibcode:2018NatSR...8..980S. doi:10.1038/s41598-018-19465-0. PMC   5772480 . PMID   29343868.
6. Zhang HL, Guo YQ, Liu S, Ye ZP, Li LC, Hu BX, Li ZL, Chen YH, Feng GK, Shen HQ, Deng R, Zhu XF (2025-04-17). "Galectin-13 reduces membrane localization of SLC7A11 for ferroptosis propagation" . Nature Chemical Biology: 1–13. doi:10.1038/s41589-025-01888-2. ISSN   1552-4469.
7. Huppertz B, Meiri H, Gizurarson S, Osol G, Sammar M (February 2013). "Placental protein 13 (PP13): a new biological target shifting individualized risk assessment to personalized drug design combating pre-eclampsia". Human Reproduction Update. 19 (4): 391–405. doi: 10.1093/humupd/dmt003 . PMID   23420029.

External links

• Overview of all the structural information available in the PDB for UniProt : Q9UHV8 (Human Galactoside-binding soluble lectin 13) at the PDBe-KB .