LGTN

Last updated
EIF2D
Identifiers
Aliases EIF2D , HCA56, LGTN, eukaryotic translation initiation factor 2D
External IDs OMIM: 613709; MGI: 109342; HomoloGene: 38244; GeneCards: EIF2D; OMA:EIF2D - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001201478
NM_006893

NM_001136070
NM_010709

RefSeq (protein)

NP_001188407
NP_008824

NP_001129542
NP_034839

Location (UCSC) Chr 1: 206.57 – 206.61 Mb Chr 1: 131.08 – 131.12 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ligatin, otherwise known as eIF2D, is a protein that in humans is encoded by the LGTN gene. [5] [6] This protein is not a component of the heterotrimeric eIF2 complex, but instead functions in different pathways of eukaryotic translation.

Contents

Function

This gene encodes a protein receptor that localizes phosphoglycoproteins within endosomes and at the cell periphery. This trafficking receptor for phosphoglycoproteins may play a role in neuroplasticity by modulating cell-cell interactions, intracellular adhesion, and protein binding at membrane surfaces. In hippocampal neurons, long-lasting down-regulation of ligation mRNA levels occurs via post-transcriptional RNA processing following glutamate receptor activation. This protein contains single PUA and SUI1 domains and these domains may function in RNA binding and translation initiation, respectively. [6]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000143486 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026427 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Jakoi ER, Brown AL, Ho YS, Snyderman R (June 1989). "Molecular cloning of the cDNA for ligatin". Journal of Cell Science. 93 ( Pt 2) (2): 227–32. doi:10.1242/jcs.93.2.227. PMID   2482295.
  6. 1 2 "Entrez Gene: LGTN ligatin".

Further reading