LGTN

Last updated
EIF2D
Identifiers
Aliases EIF2D , HCA56, LGTN, eukaryotic translation initiation factor 2D
External IDs OMIM: 613709 MGI: 109342 HomoloGene: 38244 GeneCards: EIF2D
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001201478
NM_006893

NM_001136070
NM_010709

RefSeq (protein)

NP_001188407
NP_008824

NP_001129542
NP_034839

Location (UCSC) Chr 1: 206.57 – 206.61 Mb Chr 1: 131.15 – 131.19 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ligatin, otherwise known as eIF2D, is a protein that in humans is encoded by the LGTN gene. [5] [6] This protein is not a component of the heterotrimeric eIF2 complex, but instead functions in different pathways of eukaryotic translation.

Contents

Function

This gene encodes a protein receptor that localizes phosphoglycoproteins within endosomes and at the cell periphery. This trafficking receptor for phosphoglycoproteins may play a role in neuroplasticity by modulating cell-cell interactions, intracellular adhesion, and protein binding at membrane surfaces. In hippocampal neurons, long-lasting down-regulation of ligation mRNA levels occurs via post-transcriptional RNA processing following glutamate receptor activation. This protein contains single PUA and SUI1 domains and these domains may function in RNA binding and translation initiation, respectively. [6]

See also

Related Research Articles

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SSR1

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PGRMC1

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GRASP55

Golgi reassembly-stacking protein of 55 kDa (GRASP55) also known as golgi reassembly-stacking protein 2 (GORASP2) is a protein that in humans is encoded by the GORASP2 gene. It was identified by its homology with GRASP65 and the protein's amino acid sequence was determined by analysis of a molecular clone of its complementary DNA. The first (N-terminus) 212 amino acid residues of GRASP55 are highly homologous to those of GRASP65, but the remainder of the 454 amino acid residues are highly diverged from GRASP65. The conserved region is known as the GRASP domain, and it is conserved among GRASPs of a wide variety of eukaryotes, but not plants. The C-terminus portion of the molecule is called the SPR domain. GRASP55 is more closely related to homologues in other species, suggesting that GRASP55 is ancestral to GRASP65. GRASP55 is found associated with the medial and trans cisternae of the Golgi apparatus.

SSR2

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BLZF1

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REEP2 Protein-coding gene in humans

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000143486 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026427 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Jakoi ER, Brown AL, Ho YS, Snyderman R (June 1989). "Molecular cloning of the cDNA for ligatin". Journal of Cell Science. 93 ( Pt 2) (2): 227–32. doi:10.1242/jcs.93.2.227. PMID   2482295.
  6. 1 2 "Entrez Gene: LGTN ligatin".

Further reading