LHX2

Last updated

LHX2
Protein LHX2 PDB 2dmq.png
Identifiers
Aliases LHX2 , LH2, hLhx2, LIM homeobox 2
External IDs OMIM: 603759; MGI: 96785; HomoloGene: 55848; GeneCards: LHX2; OMA:LHX2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004789

NM_001290646
NM_010710

RefSeq (protein)

NP_004780

NP_001277575
NP_034840

Location (UCSC) Chr 9: 124 – 124.03 Mb Chr 2: 38.23 – 38.26 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

LIM/homeobox protein Lhx2 is a protein that in humans is encoded by the LHX2 gene. [5] [6] [7]

Contents

This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution. [7]

Interactions

LHX2 has been shown to interact with CITED2. [8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000106689 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000000247 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wu HK, Heng HH, Siderovski DP, Dong WF, Okuno Y, Shi XM, Tsui LC, Minden MD (July 1996). "Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1". Oncogene. 12 (6): 1205–1212. PMID   8649822.
  6. Rincon-Limas DE, Lu CH, Canal I, Calleja M, Rodriguez-Esteban C, Izpisua-Belmonte JC, Botas J (April 1999). "Conservation of the expression and function of apterous orthologs in Drosophila and mammals". Proc Natl Acad Sci U S A. 96 (5): 2165–2170. Bibcode:1999PNAS...96.2165R. doi: 10.1073/pnas.96.5.2165 . PMC   26754 . PMID   10051612.
  7. 1 2 "Entrez Gene: LHX2 LIM homeobox 2".
  8. Glenn, D J; Maurer R A (December 1999). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression". J. Biol. Chem. 274 (51). UNITED STATES: 36159–36167. doi: 10.1074/jbc.274.51.36159 . ISSN   0021-9258. PMID   10593900.

Further reading