LIN7B

LIN7B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DKR
Identifiers
Aliases	LIN7B , LIN-7B, MALS-2, MALS2, VELI2, lin-7 homolog B, crumbs cell polarity complex component
External IDs	OMIM: 612331 MGI: 1330858 HomoloGene: 22648 GeneCards: LIN7B
Gene location (Human)
Chr.	Chromosome 19 (human)
End	49,118,460 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,370,583 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• PDZ domain binding ; • protein domain specific binding ; • L27 domain binding ; • GO:0001948 protein binding ;
Cellular component	• postsynaptic membrane ; • GO:0097483, GO:0097481 postsynaptic density ; • membrane ; • cell-cell junction ; • bicellular tight junction ; • plasma membrane ; • cell junction ; • basolateral plasma membrane ; • neuron projection ; • presynapse ; • synapse ; • MPP7-DLG1-LIN7 complex ;
Biological process	• protein localization to basolateral plasma membrane ; • maintenance of epithelial cell apical/basal polarity ; • protein transport ; • GO:0010554 neurotransmitter secretion ; • exocytosis ;
	Sources:Amigo / QuickGO
Orthologs
	64130
	22342
	ENSG00000104863
	ENSMUSG00000003872
	Q9HAP6
	O88951
	NM_001308419 ; NM_022165
	NM_011698
	NP_001295348 ; NP_071448
	NP_035828
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated June 11, 2021

Lin-7 homolog B is a protein that in humans is encoded by the LIN7B gene.^[5]^[6]

Interactions

LIN7B has been shown to interact with:

Related Research Articles

The renal outer medullary potassium channel (ROMK) is an ATP-dependent potassium channel (K_ir1.1) that transports potassium out of cells. It plays an important role in potassium recycling in the thick ascending limb (TAL) and potassium secretion in the cortical collecting duct (CCD) of the nephron. In humans, ROMK is encoded by the KCNJ1 gene. Multiple transcript variants encoding different isoforms have been found for this gene.

The K_ir2.1 inward-rectifier potassium ion channel is a lipid-gated ion channel encoded by the KCNJ2 gene.

PSD-95 also known as SAP-90 is a protein that in humans is encoded by the DLG4 gene.

Peripheral plasma membrane protein CASK is a protein that in humans is encoded by the CASK gene. This gene is also known by several other names: CMG 2, calcium/calmodulin-dependent serine protein kinase 3 and membrane-associated guanylate kinase 2.

Disks large homolog 3 (DLG3) also known as neuroendocrine-DLG or synapse-associated protein 102 (SAP-102) is a protein that in humans is encoded by the DLG3 gene. DLG3 is a member of the membrane-associated guanylate kinase (MAGUK) superfamily of proteins.

Disks large homolog 2 (DLG2) also known as channel-associated protein of synapse-110 (chapsyn-110) or postsynaptic density protein 93 (PSD-93) is a protein that in humans is encoded by the DLG2 gene.

Amyloid beta A4 precursor protein-binding family A member 1 is a protein that in humans is encoded by the APBA1 gene.

Na(+)/H(+) exchange regulatory cofactor NHE-RF3 is a protein that in humans is encoded by the PDZK1 gene.

G protein-activated inward rectifier potassium channel 2 is a protein that in humans is encoded by the KCNJ6 gene. Mutation in KCNJ6 gene has been proposed to be the cause of Keppen-Lubinsky Syndrome (KPLBS).

Golgi-associated PDZ and coiled-coil motif-containing protein is a protein that in humans is encoded by the GOPC gene.

Potassium inwardly-rectifying channel, subfamily J, member 4, also known as KCNJ4 or K_ir2.3, is a human gene.

Potassium inwardly-rectifying channel, subfamily J, member 8, also known as KCNJ8, is a human gene encoding the K_ir6.1 protein. A mutation in KCNJ8 has been associated with cardiac arrest in the early repolarization syndrome.

Beta-2-syntrophin is a protein that in humans is encoded by the SNTB2 gene.

ATP-sensitive inward rectifier potassium channel 12 is a lipid-gated ion channel that in humans is encoded by the KCNJ12 gene.

Beta-1-syntrophin is a protein that in humans is encoded by the SNTB1 gene.

Potassium inwardly-rectifying channel, subfamily J, member 3, also known as KCNJ3 or K_ir3.1, is a human gene.

MAGUK p55 subfamily member 6 is a protein that in humans is encoded by the MPP6 gene.

Potassium inwardly-rectifying channel, subfamily J, member 15, also known as KCNJ15 is a human gene, which encodes the K_ir4.2 protein.

Lin-7 homolog A is a protein that in humans is encoded by the LIN7A gene.

Lin-7 homolog C is a protein that in humans is encoded by the LIN7C gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000104863 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003872 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Jo K, Derin R, Li M, Bredt DS (Jun 1999). "Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex". J Neurosci. 19 (11): 4189–99. doi: 10.1523/JNEUROSCI.19-11-04189.1999 . PMC 6782594 . PMID 10341223.
↑ "Entrez Gene: LIN7B lin-7 homolog B (C. elegans)".
↑ Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ (Nov 2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current". J. Biol. Chem. 279 (45): 46962–8. doi: 10.1074/jbc.M405874200 . PMID 15317815.
↑ Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (May 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi: 10.1074/jbc.M400285200 . PMID 15024025.
↑ Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (Apr 2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi: 10.1074/jbc.M400284200 . PMID 14960569.
↑ Olsen O, Liu H, Wade JB, Merot J, Welling PA (Jan 2002). "Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex". Am. J. Physiol., Cell Physiol. 282 (1): C183-95. doi:10.1152/ajpcell.00249.2001. PMID 11742811.

Butz S, Okamoto M, Südhof TC (1998). "A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain". Cell. 94 (6): 773–82. doi:10.1016/S0092-8674(00)81736-5. PMID 9753324. S2CID 12465062.
Olsen O, Liu H, Wade JB, Merot J, Welling PA (2002). "Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex". Am. J. Physiol., Cell Physiol. 282 (1): C183–95. doi:10.1152/ajpcell.00249.2001. PMID 11742811.
Coussen F, Normand E, Marchal C, Costet P, Choquet D, Lambert M, Mège RM, Mulle C (2002). "Recruitment of the kainate receptor subunit glutamate receptor 6 by cadherin/catenin complexes". J. Neurosci. 22 (15): 6426–36. doi:10.1523/JNEUROSCI.22-15-06426.2002. PMC 6758172 . PMID 12151522.
Hori K, Konno D, Maruoka H, Sobue K (2003). "MALS is a binding partner of IRSp53 at cell-cell contacts". FEBS Lett. 554 (1–2): 30–4. doi: 10.1016/S0014-5793(03)01074-3 . PMID 14596909. S2CID 30329043.
Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi: 10.1074/jbc.M400284200 . PMID 14960569.
Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi: 10.1074/jbc.M400285200 . PMID 15024025.
Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ (2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current". J. Biol. Chem. 279 (45): 46962–8. doi: 10.1074/jbc.M405874200 . PMID 15317815.
Okuhira K, Fitzgerald ML, Sarracino DA, Manning JJ, Bell SA, Goss JL, Freeman MW (2006). "Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux". J. Biol. Chem. 280 (47): 39653–64. doi: 10.1074/jbc.M510187200 . PMID 16192269.
Kawai S, Fukuda C, Mukai T, Murata K (2006). "MJ0917 in archaeon Methanococcus jannaschii is a novel NADP phosphatase/NAD kinase". J. Biol. Chem. 280 (47): 39200–7. doi: 10.1074/jbc.M506426200 . PMID 16192277.
Li Z, Benard O, Margolskee RF (2006). "Ggamma13 interacts with PDZ domain-containing proteins". J. Biol. Chem. 281 (16): 11066–73. doi: 10.1074/jbc.M600113200 . PMID 16473877.
Sudo K, Ito H, Iwamoto I, Morishita R, Asano T, Nagata K (2007). "Identification of a cell polarity-related protein, Lin-7B, as a binding partner for a Rho effector, Rhotekin, and their possible interaction in neurons". Neurosci. Res. 56 (4): 347–55. doi:10.1016/j.neures.2006.08.003. PMID 16979770. S2CID 45834664.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000104863 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003872 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10341223-5] 1 2 Jo K, Derin R, Li M, Bredt DS (Jun 1999). "Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex". J Neurosci. 19 (11): 4189–99. doi: 10.1523/JNEUROSCI.19-11-04189.1999 . PMC 6782594 . PMID 10341223.

[entrez-6] "Entrez Gene: LIN7B lin-7 homolog B (C. elegans)".

[pmid15317815-7] Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ (Nov 2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current". J. Biol. Chem. 279 (45): 46962–8. doi: 10.1074/jbc.M405874200 . PMID 15317815.

[pmid15024025-8] Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (May 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi: 10.1074/jbc.M400285200 . PMID 15024025.

[pmid14960569-9] Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (Apr 2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi: 10.1074/jbc.M400284200 . PMID 14960569.

[pmid11742811-10] Olsen O, Liu H, Wade JB, Merot J, Welling PA (Jan 2002). "Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex". Am. J. Physiol., Cell Physiol. 282 (1): C183-95. doi:10.1152/ajpcell.00249.2001. PMID 11742811.

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LIN7B

Contents

Interactions

Related Research Articles

References

Further reading