LMO7

LMO7
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2EAQ
Identifiers
Aliases	LMO7 , FBX20, FBXO20, LOMP, LIM domain 7, LMO7b
External IDs	OMIM: 604362 MGI: 1353586 HomoloGene: 83924 GeneCards: LMO7
Gene location (Human)
Chr.	Chromosome 13 (human)
End	75,859,870 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	101,934,710 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; right lung; ; upper lobe of left lung; ; Achilles tendon; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; stromal cell of endometrium; ; left ventricle; ; gastrocnemius muscle; ; minor salivary gland;
	Top expressed in
	secondary oocyte; ; corneal stroma; ; interventricular septum; ; left lung lobe; ; conjunctival fornix; ; right lung lobe; ; olfactory tubercle; ; atrium; ; right ventricle; ; extraocular muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding ; ubiquitin-protein transferase activity ; DNA-binding transcription factor activity ;
Cellular component	cytoplasm ; ubiquitin ligase complex ; nucleus ; focal adhesion ; cytosol ; nuclear envelope ; cell surface ; apical plasma membrane ;
Biological process	regulation of cell adhesion ; protein ubiquitination ; regulation of signaling ; protein polyubiquitination ; post-translational protein modification ; positive regulation of transcription by RNA polymerase II ;
	Sources:Amigo / QuickGO
Orthologs
	4008
	380928
	ENSG00000136153
	ENSMUSG00000033060
	Q8WWI1
	n/a
	NM_001306080 ; NM_005358 ; NM_015842 ; NM_015843 ; NM_001330583
	NM_201529 ; NM_001347628
NP_001293009 ; NP_001317512 ; NP_005349 ; NP_056667 ; NP_001353561 ;
	NP_001353562 ; NP_001353563 ; NP_001353565 ; NP_001293009.1
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 04, 2024

LIM domain only protein 7 is a protein that in humans is encoded by the LMO7 gene.^[5]^[6]^[7]

This gene encodes a protein containing a calponin homology (CH) domain, a PDZ domain, and a LIM domain. An F-box (FBX) domain is present in alternative splice variants. Members of the LIM protein family carry the LIM domain, a unique cysteine-rich zinc-binding domain. Members of the FBX protein family are involved in protein-protein interactions. The encoded protein may be involved in protein-protein interactions. Multiple alternative splice variants have been described but their full-length sequences have not been determined.^[7]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000136153 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033060 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Putilina T, Jaworski C, Gentleman S, McDonald B, Kadiri M, Wong P (Dec 1998). "Analysis of a human cDNA containing a tissue-specific alternatively spliced LIM domain". Biochem Biophys Res Commun. 252 (2): 433–9. doi:10.1006/bbrc.1998.9656. PMID 9826547.
↑ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. Bibcode:1999CBio....9.1177C. doi: 10.1016/S0960-9822(00)80020-2 . PMID 10531035.
1 2 "Entrez Gene: LMO7 LIM domain 7".

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID 12168954.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi: 10.1093/dnares/5.6.355 . PMID 10048485.
Rozenblum E, Vahteristo P, Sandberg T, et al. (2002). "A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes". Hum. Genet. 110 (2): 111–21. doi:10.1007/s00439-001-0646-6. PMID 11935316. S2CID 21371347.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi: 10.1016/j.cub.2004.07.051 . PMID 15324660. S2CID 2371325.
Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi: 10.1074/mcp.M500021-MCP200 . PMID 15778465.
Kim J, Bhinge AA, Morgan XC, Iyer VR (2005). "Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment". Nat. Methods. 2 (1): 47–53. doi:10.1038/nmeth726. PMID 15782160. S2CID 6135437.
Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
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Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Holaska JM, Rais-Bahrami S, Wilson KL (2007). "Lmo7 is an emerin-binding protein that regulates the transcription of emerin and many other muscle-relevant genes". Hum. Mol. Genet. 15 (23): 3459–72. doi: 10.1093/hmg/ddl423 . PMID 17067998.
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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000136153 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033060 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9826547-5] Putilina T, Jaworski C, Gentleman S, McDonald B, Kadiri M, Wong P (Dec 1998). "Analysis of a human cDNA containing a tissue-specific alternatively spliced LIM domain". Biochem Biophys Res Commun. 252 (2): 433–9. doi:10.1006/bbrc.1998.9656. PMID 9826547.

[pmid10531035-6] Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. Bibcode:1999CBio....9.1177C. doi: 10.1016/S0960-9822(00)80020-2 . PMID 10531035.

[entrez-7] 1 2 "Entrez Gene: LMO7 LIM domain 7".

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LMO7

Related Research Articles

References

Further reading