LRCH4

LRCH4
Identifiers
Aliases	LRCH4 , LRN, LRRN1, LRRN4, PP14183, leucine-rich repeats and calponin homology (CH) domain containing 4, leucine rich repeats and calponin homology domain containing 4
External IDs	MGI: 1917193 HomoloGene: 20532 GeneCards: LRCH4
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q22.1 Start 100,574,011 bp [1] End 100,586,129 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 G2 Start 137,627,383 bp [2] End 137,639,361 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood spleen pituitary gland monocyte anterior pituitary right lobe of thyroid gland left lobe of thyroid gland right lung tibial nerve appendix Top expressed in secondary oocyte thymus spleen testicle bone marrow stomach lung jejunum skeletal muscle tissue yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component PML body cytoplasm basolateral plasma membrane Biological process nervous system development signal transduction maintenance of epithelial cell apical/basal polarity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4034 231798 Ensembl ENSG00000077454 ENSMUSG00000093445 UniProt O75427 Q921G6 RefSeq (mRNA) NM_002319 NM_001289934 NM_001168652 NM_146164 RefSeq (protein) NP_001276863 NP_002310 NP_001162123 NP_666276 Location (UCSC) Chr 7: 100.57 – 100.59 Mb Chr 5: 137.63 – 137.64 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Leucine-rich repeat and calponin homology domain-containing protein 4 is a protein that in humans is encoded by the LRCH4 gene. ^{[5] [6]}

This gene encodes a protein that contains leucine-rich repeats (LRR) at its amino terminus and that is known to be involved in ligand binding. The carboxyl terminus may act as a membrane anchor. Identified structural elements suggest that the encoded protein resembles a receptor. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000077454 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000093445 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Glockner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (Dec 1998). "Large-Scale Sequencing of Two Regions in Human Chromosome 7q22: Analysis of 650 kb of Genomic Sequence around the EPO and CUTL1 Loci Reveals 17 Genes". Genome Res. 8 (10): 1060–73. doi:10.1101/gr.8.10.1060. PMC   310788 . PMID   9799793.
6. "Entrez Gene: LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4".

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Shiio Y, Rose DW, Aur R, et al. (2006). "Identification and Characterization of SAP25, a Novel Component of the mSin3 Corepressor Complex". Mol. Cell. Biol. 26 (4): 1386–97. doi:10.1128/MCB.26.4.1386-1397.2006. PMC   1367179 . PMID   16449650.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC   2882961 . PMID   12690205.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.