LRRC23

Last updated
LRRC23
Identifiers
Aliases LRRC23 , LRPB7, leucine rich repeat containing 23
External IDs MGI: 1315192 HomoloGene: 5082 GeneCards: LRRC23
Gene location (Human)
Ideogram human chromosome 12.svg
Chr. Chromosome 12 (human) [1]
Human chromosome 12 ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band 12p13.31Start6,873,569 bp [1]
End6,914,241 bp [1]
RNA expression pattern
PBB GE LRRC23 206076 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_201650
NM_001135217
NM_006992

NM_013588
NM_001302555

RefSeq (protein)

NP_001128689
NP_008923
NP_964013

NP_001289484

Location (UCSC) Chr 12: 6.87 – 6.91 Mb Chr 6: 124.77 – 124.78 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Leucine-rich repeat-containing protein 23 is a protein that in humans is encoded by the LRRC23 gene. [5] [6] [7]

Contents

Function

The function of LRRC23 is unknown. It is a member of the leucine-rich repeat family of proteins, which are known for participating in protein-protein interactions. Experimental evidence suggests that LRRC23 interacts with the CD28 protein in a pathway related to the immune system and development of regulatory T cells that control spontaneous autoimmune disease. [8]

Protein sequence

LRRC23 spans 343 residues containing two varieties of internally repeating sequence. Detected and aligned by RADAR, [9] the most abundant repeat is the leucine-rich repeat, repeating 9 times in bases 89-287. The other repeated sequence occurs twice in bases 3-36. The RADAR program output, below, summarizes the composition and location of all the repeats and aligns them for comparison against each other. LRRC23 RADAR Internal Repeats.png

The human genome produces three known variants of LRRC23. [7] The largest splice variant, variant 3, contains 8 exons. Variants 1 and 2 use alternative first exons, and variant 2 excludes the seventh exon, giving it a total of seven exons making up the mRNA.

Protein structure

Although the actual structure of LRRC23 is unknown, comparison to the crystal structures of various similar proteins such as 2OMW A (e-value 1.00e-17) reveals a structure typical of other leucine-rich repeat proteins. Alternating beta sheets and coils create a spiraled peptide chain forming an arch shape with beta-sheets occupying the concave surface. [10]

The aligned structure of 2OMW_A with LRRC23 spans acids 72-272 of the LRRC23 protein. Conserved asparagines are highlighted in yellow, showing the regularity of spacing and repeat structure within. This model was generated using Cn3D software provided by NCBI.

CBlast 72-272 asparagines.png

Related Research Articles

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LRRC8D protein-coding gene in the species Homo sapiens

Leucine-rich repeat-containing protein 8D is a protein that in humans is encoded by the LRRC8D gene. Researchers have found out that this protein, along with the other LRRC8 proteins LRRC8A, LRRC8B, LRRC8C, and LRRC8E, is a subunit of the heteromer protein Volume-Regulated Anion Channel. Volume-Regulated Anion Channels (VRACs) are crucial to the regulation of cell size by transporting chloride ions and various organic osmolytes, such as taurine or glutamate, across the plasma membrane, and that is not the only function these channels have been linked to.

LRRC41 protein-coding gene in the species Homo sapiens

Leucine-rich repeat-containing protein 41 is a protein that in humans is encoded by the LRRC41 gene.

LRRN2 protein-coding gene in the species Homo sapiens

Leucine-rich repeat neuronal protein 2 is a protein that in humans is encoded by the LRRN2 gene.

LRRC39 protein-coding gene in the species Homo sapiens

Leucine-rich repeat-containing protein 39 is a protein that in humans is encoded by the LRRC39 gene.

FLRT3 protein-coding gene in the species Homo sapiens

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TMEM98 protein-coding gene in the species Homo sapiens

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LRCH4 protein-coding gene in the species Homo sapiens

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LRRC8E protein-coding gene in the species Homo sapiens

Leucine-rich repeat-containing protein 8E is a protein that in humans is encoded by the LRRC8E gene. Researchers have found out that this protein, along with the other LRRC8 proteins LRRC8A, LRRC8B, LRRC8C, and LRRC8D, is sometimes a subunit of the heteromer protein Volume-Regulated Anion Channel. Volume-Regulated Anion Channels (VRACs) are crucial to the regulation of cell size by transporting chloride ions and various organic osmolytes, such as taurine or glutamate, across the plasma membrane, and that is not the only function these channels have been linked to.

LRRC17 protein-coding gene in the species Homo sapiens

Leucine-rich repeat-containing protein 17 is a protein that in humans is encoded by the LRRC17 gene.

LRRC57 protein-coding gene in the species Homo sapiens

Leucine rich repeat containing 57, also known as LRRC57, is a protein that in humans is encoded by the LRRC57 gene.

LRRC50 protein-coding gene in the species Homo sapiens

Leucine-rich repeat-containing protein 50 is a protein that in humans is encoded by the LRRC50 gene.

LRRC40 protein-coding gene in the species Homo sapiens

Leucine rich repeat containing 40 (LRRC40) is a protein that in humans is encoded by the LRRC40 gene.

LRRC24 protein-coding gene in the species Homo sapiens

Leucine rich repeat containing 24 is a protein that, in humans, is encoded by the LRRC24 gene. The protein is represented by the official symbol LRRC24, and is alternatively known as LRRC14OS. The function of LRRC24 is currently unknown. It is a member of the leucine-rich repeat (LRR) superfamily of proteins.

Leucine-rich repeat-containing protein 8B is a protein that in humans is encoded by the LRRC8B gene. Researchers have found out that this protein, along with the other LRRC8 proteins LRRC8A, LRRC8C, LRRC8D, and LRRC8E, is sometimes a subunit of the heteromer protein Volume-Regulated Anion Channel. Volume-Regulated Anion Channels (VRACs) are crucial to the regulation of cell size by transporting chloride ions and various organic osmolytes, such as taurine or glutamate, across the plasma membrane, and that is not the only function these channels have been linked to.

LRRC8C protein-coding gene in the species Homo sapiens

Leucine-rich repeat-containing protein 8C is a protein that in humans is encoded by the LRRC8C gene. Researchers have found out that this protein, along with the other LRRC8 proteins LRRC8A, LRRC8B, LRRC8D, and LRRC8E, is sometimes a subunit of the heteromer protein Volume-Regulated Anion Channel. Volume-Regulated Anion Channels (VRACs) are crucial to the regulation of cell size by transporting chloride ions and various organic osmolytes, such as taurine or glutamate, across the plasma membrane, and that is not the only function these channels have been linked to.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000010626 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030125 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tzachanis D, Berezovskaya A, Nadler LM, Boussiotis VA (Feb 2002). "Blockade of B7/CD28 in mixed lymphocyte reaction cultures results in the generation of alternatively activated macrophages, which suppress T-cell responses". Blood. 99 (4): 1465–73. doi:10.1182/blood.V99.4.1465. PMID   11830501.
  6. Chang TT, Kuchroo VK, Sharpe AH (Feb 2002). "Role of the B7-CD28/CTLA-4 pathway in autoimmune disease". Signal Transduction Pathways in Autoimmunity. Current Directions in Autoimmunity. 5. pp. 113–30. doi:10.1159/000060550. ISBN   3-8055-7308-1. PMID   11826754.
  7. 1 2 "Entrez Gene: LRRC23 leucine rich repeat containing 23".
  8. Salomon B, Lenschow DJ, Rhee L, Ashourian N, Singh B, Sharpe A, Bluestone JA (Apr 2000). "B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes". Immunity. 12 (4): 431–40. doi:10.1016/S1074-7613(00)80195-8. PMID   10795741.
  9. RADAR: European Molecular Biology Laboratory - European Bioinformatics Institute (EMBLE-EBI) Radar program:
  10. NCBI Structure CBlast https://www.ncbi.nlm.nih.gov/Structure/cblast/cblast.cgi?client=entrez&query_gi=206725447&hit=149242643&hsp=1&output=html&pagenum=1&epp=20&sort=evalue&view=graphic&subset=allmmdb

Further reading