| LRRC24 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | LRRC24 , LRRC14OS, leucine rich repeat containing 24 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | MGI: 3605040 HomoloGene: 86785 GeneCards: LRRC24 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Leucine rich repeat containing 24 is a protein that, in humans, is encoded by the LRRC24 gene. [5] The protein is represented by the official symbol LRRC24, and is alternatively known as LRRC14OS. [6] The function of LRRC24 is currently unknown. It is a member of the leucine-rich repeat (LRR) superfamily of proteins.
In humans, LRRC24 is located on Chromosome 8 (8q24.3). The gene spans approximately 4.66 kb on the opposite strand. [5] LRRC24 is composed of five exons, and only a single gene isoform has been identified. [5]
LRRC24 is a transmembrane protein of unknown function. Human LRRC24 consists of 513 amino acids including a 23 amino acid signal peptide. [5] [7] The mature form of the protein has a molecular weight of 52.9 kDa. [8] The isoelectric point of the mature human protein is 7.98 [9] The protein is largely composed of alpha helices. [10]
LRRC24 is a single-pass transmembrane protein. The protein consists of six leucine-rich repeats and an immunoglobulin-like domain. [5] [11]
| Feature | Position(s) | Description |
|---|---|---|
| Signal Peptide | 1-23 | [12] |
| Domain | 24-50 | Leucine rich repeat N-terminal domain (LRRNT) [13] [14] |
| Repeat | 51-72 | Leucine rich repeat 1 (LRR 1) [13] [14] |
| Repeat | 75-96 | LRR 2 [13] [14] |
| Repeat | 99-120 | LRR 3 [13] [14] |
| Repeat | 123-144 | LRR 4 [13] [14] |
| Repeat | 147-168 | LRR 5 [13] [14] |
| Repeat | 171-192 | LRR 6 [13] [14] |
| Domain | 204-257 | Leucine rich repeat C-terminal domain (LRRCT) [13] [14] |
| Domain | 259-364 | Immunoglobulin-like domain (Ig-like) [13] [14] |
| Domain | 406-426 | Transmembrane domain (TMEM) [15] |
| Motif | 427-436 | Arginine-rich motif (ARM) [13] |
LRRC24 is a secreted protein as is evidenced by the presence of a signal peptide. The structure of the protein suggests that it localizes to the cell membrane.
LRRC24 is conserved in Euteleostomi with the exception of Aves. [5] [18] Also, based on sequence homology analysis, distant orthologs of LRRC24 are also conserved in invertebrates of phyla Mollusca and Arthropoda. [5] No human paralogs of LRRC24 have been identified.
Microarray and in situ hybridization experiments suggest LRRC24 is primarily expressed within the brain. [20] [21] [22] Expression is observed to be especially high within the midbrain, neocortex, and tissues of the limbic system, including the hypothalamus and hippocampal formation. [20] [22] [23]
Protein-protein interactions of LRRC24 implicate the protein with cell signaling, cell migration, and axon guidance. ROBO2 was found to interact with LRRC24. [24] [25] ROBO2 is a member of the Roundabout gene family, which are well known to play a significant role in nervous system development. Also, LRRC24 was found to interact with LRRTM4, a protein believed to be involved in synaptogenesis, as well as the maintenance of the nervous system in vertebrates. [25]
LRRC24 has also been found to interact with IGFBP7, a known regulator of insulin-like growth factors (IGFs). [25] IGFBP7 is also involved in the stimulation of cell adhesion.
To date, no study has specifically implicated LRRC24 or the LRRC24 gene with any case of clinical significance. [26]
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