LSM6

LSM6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3JCR
Identifiers
Aliases	LSM6 , YDR378C, LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
External IDs	OMIM: 607286 MGI: 1925901 HomoloGene: 38271 GeneCards: LSM6
Gene location (Human)
Chr.	Chromosome 4 (human)
End	146,200,000 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	79,547,769 bp
RNA expression pattern
	Top expressed in
	monocyte; ; appendix; ; lymph node; ; Achilles tendon; ; abdominal fat; ; ganglionic eminence; ; right lung; ; islet of Langerhans; ; spleen; ; bone marrow;
	Top expressed in
	hand; ; endocardial cushion; ; atrioventricular valve; ; abdominal wall; ; dermis; ; neural tube; ; adrenal gland; ; medial ganglionic eminence; ; skeletal muscle tissue; ; extraocular muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; RNA binding ;
Cellular component	cytoplasm ; cytosol ; nucleoplasm ; small nuclear ribonucleoprotein complex ; spliceosomal complex ; extracellular exosome ; nucleus ; P-body ; U6 snRNP ; nucleolus ; sno(s)RNA-containing ribonucleoprotein complex ; U4/U6 x U5 tri-snRNP complex ; U2-type precatalytic spliceosome ; Lsm2-8 complex ;
Biological process	tRNA processing ; mRNA processing ; RNA splicing ; exonucleolytic catabolism of deadenylated mRNA ; rRNA processing ; mRNA splicing, via spliceosome ; maturation of SSU-rRNA ;
	Sources:Amigo / QuickGO
Orthologs
	11157
	78651
	ENSG00000164167
	ENSMUSG00000031683
	P62312
	P62313
	NM_007080
	NM_001191004 ; NM_030145
	NP_009011
	NP_001177933 ; NP_084421
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 28, 2022

U6 snRNA-associated Sm-like protein LSm6 is a protein that in humans is encoded by the LSM6 gene.^[5]^[6]^[7]

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop.

The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM]^[7]

Related Research Articles

In molecular biology, LSm proteins are a family of RNA-binding proteins found in virtually every cellular organism. LSm is a contraction of 'like Sm', because the first identified members of the LSm protein family were the Sm proteins. LSm proteins are defined by a characteristic three-dimensional structure and their assembly into rings of six or seven individual LSm protein molecules, and play a large number of various roles in mRNA processing and regulation.

Small nuclear ribonucleoprotein Sm D1 is a protein that in humans is encoded by the SNRPD1 gene.

U4/U6 small nuclear ribonucleoprotein Prp3 is a protein that in humans is encoded by the PRPF3 gene.

U5 small nuclear ribonucleoprotein 200 kDa helicase is an enzyme that in humans is encoded by the SNRNP200 gene.

Small nuclear ribonucleoprotein F is a protein that in humans is encoded by the SNRPF gene.

Splicing factor 3B subunit 2 is a protein that in humans is encoded by the SF3B2 gene.

Splicing factor 3B subunit 4 is a protein that in humans is encoded by the SF3B4 gene.

Splicing factor 3B subunit 3 is a protein that in humans is encoded by the SF3B3 gene.

116 kDa U5 small nuclear ribonucleoprotein component is a protein that in humans is encoded by the EFTUD2 gene.

Small nuclear ribonucleoprotein G is a protein that in humans is encoded by the SNRPG gene.

U6 snRNA-associated Sm-like protein LSm5 is a protein that in humans is encoded by the LSM5 gene.

U6 snRNA-associated Sm-like protein LSm4 is a protein that in humans is encoded by the LSM4 gene.

U6 snRNA-associated Sm-like protein LSm1 is a protein that in humans is encoded by the LSM1 gene.

U6 snRNA-associated Sm-like protein LSm3 is a protein that in humans is encoded by the LSM3 gene.

U6 snRNA-associated Sm-like protein LSm7 is a protein that in humans is encoded by the LSM7 gene.

U6 snRNA-associated Sm-like protein LSm2 is a protein that in humans is encoded by the LSM2 gene.

U6 snRNA-associated Sm-like protein LSm8 is a protein that in humans is encoded by the LSM8 gene.

U7 snRNA-associated Sm-like protein LSm10 is a protein that in humans is encoded by the LSM10 gene.

Peptidyl-prolyl cis-trans isomerase H is an enzyme that in humans is encoded by the PPIH gene.

Probable ATP-dependent RNA helicase DDX46 is an enzyme that in humans is encoded by the DDX46 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000164167 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031683 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Seraphin B (Aug 1999). "Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin". EMBO J. 18 (12): 3451–62. doi:10.1093/emboj/18.12.3451. PMC 1171424 . PMID 10369684.
↑ Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Luhrmann R (Dec 1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro". EMBO J. 18 (20): 5789–802. doi:10.1093/emboj/18.20.5789. PMC 1171645 . PMID 10523320.
1 2 "Entrez Gene: LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)".

Friesen WJ, Dreyfuss G (2000). "Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN)". J. Biol. Chem. 275 (34): 26370–5. doi: 10.1074/jbc.M003299200 . PMID 10851237.
Eystathioy T, Peebles CL, Hamel JC, et al. (2002). "Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera". Arthritis Rheum. 46 (3): 726–34. doi: 10.1002/art.10220 . PMID 11920408.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T (2003). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci". RNA. 8 (12): 1489–501. doi:10.1017/S1355838202021726. PMC 1370355 . PMID 12515382.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147 . PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000164167 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031683 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10369684-5] Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Seraphin B (Aug 1999). "Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin". EMBO J. 18 (12): 3451–62. doi:10.1093/emboj/18.12.3451. PMC 1171424 . PMID 10369684.

[pmid10523320-6] Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Luhrmann R (Dec 1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro". EMBO J. 18 (20): 5789–802. doi:10.1093/emboj/18.20.5789. PMC 1171645 . PMID 10523320.

[entrez-7] 1 2 "Entrez Gene: LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)".

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LSM6

Related Research Articles

References

Further reading