LUC7L

LUC7L
Identifiers
Aliases	LUC7L , LUC7-LIKE, LUC7B1, Luc7, SR+89, hLuc7B1, LUC7 like
External IDs	OMIM: 607782; MGI: 1914228; HomoloGene: 100558; GeneCards: LUC7L; OMA:LUC7L - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p13.3 Start 188,969 bp [1] End 229,463 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17 A3.3|17 13.09 cM Start 26,471,870 bp [2] End 26,504,478 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii sural nerve anterior pituitary left lobe of thyroid gland right lobe of thyroid gland cerebellar hemisphere right hemisphere of cerebellum right uterine tube canal of the cervix body of uterus Top expressed in neural layer of retina Rostral migratory stream abdominal wall ventricular zone medullary collecting duct epiblast morula facial motor nucleus ventromedial nucleus substantia nigra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RS domain binding protein binding mRNA binding identical protein binding Cellular component U1 snRNP U2-type prespliceosome nucleus Biological process mRNA splice site selection negative regulation of striated muscle tissue development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55692 66978 Ensembl ENSG00000007392 ENSMUSG00000024188 UniProt Q9NQ29 Q1W6G4 Q9CYI4 RefSeq (mRNA) NM_018032 NM_201412 NM_001320226 NM_001330420 NM_025881 NM_028190 RefSeq (protein) NP_001307155 NP_001317349 NP_060502 NP_958815 NP_060502.1 NP_001307155.1 NP_080157 NP_082466 Location (UCSC) Chr 16: 0.19 – 0.23 Mb Chr 17: 26.47 – 26.5 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Putative RNA-binding protein Luc7-like 1 is a protein that in humans is encoded by the LUC7L gene. ^[5]

The LUC7L gene may represent a mammalian heterochromatic gene, encoding a putative RNA-binding protein similar to the yeast Luc7p subunit of the U1 snRNP splicing complex that is normally required for 5-prime splice site selection. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000007392 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024188 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: LUC7L LUC7-like (S. cerevisiae)".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi: 10.1093/hmg/10.4.339 . PMID   11157797.
• Tufarelli C, Frischauf AM, Hardison R, et al. (2001). "Characterization of a widely expressed gene (LUC7-LIKE; LUC7L) defining the centromeric boundary of the human alpha-globin domain". Genomics. 71 (3): 307–14. doi:10.1006/geno.2000.6394. PMID   11170747.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi: 10.1016/j.molcel.2004.09.016 . PMID   15383276.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.