LYPLA3

PLA2G15
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4X90, 4X91, 4X92, 4X93, 4X94, 4X95, 4X97
Identifiers
Aliases	PLA2G15 , ACS, GXVPLA2, LLPL, LPLA2, LYPLA3, phospholipase A2 group XV
External IDs	OMIM: 609362 MGI: 2178076 HomoloGene: 8200 GeneCards: PLA2G15
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16q22.1 Start 68,245,304 bp [1] End 68,261,058 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 D3 Start 106,877,031 bp [2] End 106,891,347 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle left ventricle stromal cell of endometrium right lobe of liver monocyte spleen kidney right coronary artery right lobe of thyroid gland upper lobe of left lung Top expressed in secondary oocyte blastocyst calvaria morula spleen yolk sac white adipose tissue brown adipose tissue right lung lobe subcutaneous adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity O-acyltransferase activity lysophospholipase activity acyltransferase activity hydrolase activity phospholipid binding calcium-independent phospholipase A2 activity Cellular component membrane mitochondrion lysosome extracellular exosome extracellular space nucleoplasm intracellular membrane-bounded organelle extracellular region Biological process fatty acid catabolic process phosphatidylcholine catabolic process ceramide metabolic process lipid metabolism fatty acid metabolic process lipid catabolic process phosphatidylethanolamine catabolic process glycerophospholipid metabolic process phosphatidylcholine metabolic process phospholipid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23659 192654 Ensembl ENSG00000103066 ENSMUSG00000031903 UniProt Q8NCC3 Q8VEB4 RefSeq (mRNA) NM_012320 NM_001363551 NM_133792 NM_001357319 RefSeq (protein) NP_036452 NP_001350480 NP_598553 NP_001344248 Location (UCSC) Chr 16: 68.25 – 68.26 Mb Chr 8: 106.88 – 106.89 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

LYPLA3, also known as Group XV phospholipase A2, is an enzyme that in humans is encoded by the PLA2G15 gene. ^{[5] [6] [7]}

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000103066 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031903 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M (May 1999). "Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase". Biochem Biophys Res Commun. 257 (1): 50–6. doi:10.1006/bbrc.1999.0411. PMID   10092508.
6. Schaloske RH, Dennis EA (Nov 2006). "The phospholipase A2 superfamily and its group numbering system". Biochim Biophys Acta. 1761 (11): 1246–59. doi:10.1016/j.bbalip.2006.07.011. PMID   16973413.
7. "Entrez Gene: LYPLA3 lysophospholipase 3 (lysosomal phospholipase A2)".

Further reading

• Wang A, Dennis EA (1999). "Mammalian lysophospholipases". Biochim. Biophys. Acta. 1439 (1): 1–16. doi:10.1016/s1388-1981(99)00063-3. PMID   10395961.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Ohta T, Michel JJ, Schottelius AJ, Xiong Y (1999). "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity". Mol. Cell. 3 (4): 535–41. doi: 10.1016/S1097-2765(00)80482-7 . PMID   10230407. S2CID   19371828.
• Hiraoka M, Abe A, Shayman JA (2002). "Cloning and characterization of a lysosomal phospholipase A2, 1-O-acylceramide synthase". J. Biol. Chem. 277 (12): 10090–9. doi: 10.1074/jbc.M111977200 . PMID   11790796.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Abe A, Poucher HK, Hiraoka M, Shayman JA (2004). "Induction of lysosomal phospholipase A2 through the retinoid X receptor in THP-1 cells". J. Lipid Res. 45 (4): 667–73. doi: 10.1194/jlr.M300342-JLR200 . PMID   14754907.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC   2286551 . PMID   15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.