Lactiferous duct

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Lactiferous duct
Breast anatomy normal scheme.png
The Breast: cross-section scheme of the mammary gland.
Details
Identifiers
Latin ductus lactiferi, tubulus lactiferi
TA98 A16.0.02.010
TA2 7103
FMA 58006
Anatomical terminology

Lactiferous ducts are ducts that converge and form a branched system connecting the nipple to the lobules of the mammary gland. When lactogenesis occurs, under the influence of hormones, the milk is moved to the nipple by the action of smooth muscle contractions along the ductal system to the tip of the nipple. They are also referred to as galactophores, galactophorous ducts, mammary ducts, mamillary ducts or milk ducts. [1] [2]

Contents

Structure

Lactiferous ducts are lined by a columnar epithelium supported by myoepithelial cells. Prior to 2005, it was thought within the areola the lactiferous duct would dilate to form the lactiferous sinus in which milk accumulates between breastfeeding sessions. However past studies have shown that the lactiferous sinus does not exist. [3]

Function

The columnar epithelium plays a key role in balancing milk production, milk stasis and reabsorption. The cells of the columnar epithelium form tight junctions which are regulated by hormones and local factors like pressure and casein content. Prolactin and/or placental lactogen are required for tight junction closure while progesterone is the main hormone preventing closure before birth. [4] [5]

Clinical significance

The majority of breast diseases either originate from lactiferous ducts or are closely related. The high susceptibility to benign and malignant diseases is in part a consequence of the cycling hormonal growth stimulation resulting in a high cell turnover and accumulation of defects and complicated hormonal equilibrium which is highly sensitive to disturbance. [ citation needed ]

See also

Related Research Articles

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The breast is one of two prominences located on the upper ventral region of a primate's torso. Both females and males develop breasts from the same embryological tissues.

<span class="mw-page-title-main">Nipple</span> Part of the breast

The nipple is a raised region of tissue on the surface of the breast from which, in females, milk leaves the breast through the lactiferous ducts to breastfeed an infant. The milk can flow through the nipple passively or it can be ejected by smooth muscle contractions that occur along with the ductal system. Male mammals also have nipples but without the same level of function, and often surrounded by body hair.

<span class="mw-page-title-main">Epithelium</span> Tissue lining the surfaces of organs in animals

Epithelium or epithelial tissue is a thin, continuous, protective layer of compactly packed cells with a little intercellular matrix. Epithelial tissues line the outer surfaces of organs and blood vessels throughout the body, as well as the inner surfaces of cavities in many internal organs. An example is the epidermis, the outermost layer of the skin. Epithelial tissue is one of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue. These tissues also lack blood or lymph supply. The tissue is supplied by nerves.

<span class="mw-page-title-main">Mammary gland</span> Exocrine gland in humans and other mammals

A mammary gland is an exocrine gland in humans and other mammals that produces milk to feed young offspring. Mammals get their name from the Latin word mamma, "breast". The mammary glands are arranged in organs such as the breasts in primates, the udder in ruminants, and the dugs of other animals. Lactorrhea, the occasional production of milk by the glands, can occur in any mammal, but in most mammals, lactation, the production of enough milk for nursing, occurs only in phenotypic females who have gestated in recent months or years. It is directed by hormonal guidance from sex steroids. In a few mammalian species, male lactation can occur. With humans, male lactation can occur only under specific circumstances.

<span class="mw-page-title-main">Mastitis</span> Medical condition

Mastitis is inflammation of the breast or udder, usually associated with breastfeeding. Symptoms typically include local pain and redness. There is often an associated fever and general soreness. Onset is typically fairly rapid and usually occurs within the first few months of delivery. Complications can include abscess formation.

<span class="mw-page-title-main">Breast reduction</span> Plastic surgery procedure

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<span class="mw-page-title-main">Breast engorgement</span> Medical condition

Breast engorgement occurs in the mammary glands due to expansion and pressure exerted by the synthesis and storage of breast milk. It is also a main factor in altering the ability of the infant to latch-on. Engorgement changes the shape and curvature of the nipple region by making the breast inflexible, flat, hard, and swollen. The nipples on an engorged breast are flat or inverted. Sometimes it may lead to striae on nipples, mainly a preceding symptom of septation mastitis.

<span class="mw-page-title-main">Inverted nipple</span> Medical condition

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<span class="mw-page-title-main">Mammary ridge</span> Primordium specific for the development of the mammary gland

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<span class="mw-page-title-main">Duct (anatomy)</span>

In anatomy and physiology, a duct is a circumscribed channel leading from an exocrine gland or organ.

<span class="mw-page-title-main">Duct ectasia of breast</span> Medical condition

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<span class="mw-page-title-main">Lactation</span> Release of milk from the mammary glands

Lactation describes the secretion of milk from the mammary glands and the period of time that a mother lactates to feed her young. The process naturally occurs with all sexually mature female mammals, although it may predate mammals. The process of feeding milk in all female creatures is called nursing, and in humans it is also called breastfeeding. Newborn infants often produce some milk from their own breast tissue, known colloquially as witch's milk.

The term nonpuerperal mastitis describes inflammatory lesions of the breast (mastitis) that occur unrelated to pregnancy and breastfeeding.

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Breast development, also known as mammogenesis, is a complex biological process in primates that takes place throughout a female's life.

<span class="mw-page-title-main">Mammary alveolus</span> Small cavity or sac found in the mammary gland

A mammary alveolus is a small cavity or sac found in the mammary gland. Mammary alveoli are the site of milk production and storage in the mammary gland. Mammary alveoli cluster into groups called mammary lobules, and each breast may contain 15 to 20 of these lobules. The lobules drain milk through the lactiferous ducts out of the nipples.

A nipple bleb is a blister on the nipple that can be filled with serous or other fluid. It may be pink or light yellow. It is thin-walled and may appear as a small blister, more than 5 mm in diameter. It can also be referred to as a bulla. Some clinicians may also include milk blisters as a type of bleb. In addition, a blocked Montgomery gland may also be called a nipple bleb though its cause is different than a milk or serous-filled bleb on the nipple. In some cases the bleb may be associated with an adjacent blocked sebaceous cyst.

Nipple pain is a common symptom of pain at the nipple that occurs in women during breastfeeding after childbirth. The pain shows the highest intensity during the third to the seventh day postpartum and becomes most severe on the third day postpartum.

<span class="mw-page-title-main">Establishment of breastfeeding</span>

Establishment of breastfeeding refers to the initiation of providing breast milk of mother to baby. According to the World Health Organisation(WHO), breastfeeding is the best way to provide nourishment, including essential nutrients, energy and antibodies, to infants and toddlers. The start of breastfeeding is supported by the milk production which depends on the development of internal and external breast structure and hormonal control on milk secretion. Besides milk supply, adopting the correct approach of breastfeeding helps build up the maternal bond, which in turn promotes breastfeeding. Not only does nursing strengthen the mother-child relationship, but it also improves the intelligence and immunity of breastfed children and diminishes breastfeeding mothers' risks to have ovarian and breast cancer.

References

  1. "galactophore" . Retrieved 13 August 2017 via The Free Dictionary.
  2. "galactophorous ducts" . Retrieved 13 August 2017.
  3. Ramsay, D. T.; Kent, J. C.; Hartmann, R. A.; Hartmann, P. E. (2005). "Anatomy of the lactating human breast redefined with ultrasound imaging". Journal of Anatomy. 206 (6): 525–534. doi:10.1111/j.1469-7580.2005.00417.x. PMC   1571528 . PMID   15960763.
  4. Nguyen, D. A.; Parlow, A. F.; Neville, M. C. (2001). "Hormonal regulation of tight junction closure in the mouse mammary epithelium during the transition from pregnancy to lactation". The Journal of Endocrinology. 170 (2): 347–356. doi: 10.1677/joe.0.1700347 . PMID   11479131.
  5. Nguyen, D. A.; Neville, M. C. (1998). "Tight junction regulation in the mammary gland". Journal of Mammary Gland Biology and Neoplasia. 3 (3): 233–246. doi:10.1023/A:1018707309361. PMID   10819511. S2CID   36182729.