Legal cultivation of opium for medicinal purposes is carried out in India, only in selected areas, under free licensing conditions. India is the world's largest manufacturer of legal opium for the pharmaceutical industry according to the CIA World Factbook. [1] India is one among 12 countries in world where legal cultivation for medical use is permissible within the ambit of United Nations, Single Convention on Narcotic Drugs 1961. In India legal cultivation is done primarily in Madhya Pradesh, Rajasthan and Uttar Pradesh. [2] Despite producing poppy for opium production India depends heavily on imports to meet need of Poppy seed for edible purposes [3] and domestic Codeine demand for medical purposes (more than 30% by imports). Opium is heavily imported from its top producing nations like Afghanistan. There is also an account of Opium black marketing in India.
The cultivation of poppy in India for Opium production has occurred since as early as 1000CE, where it was called "Dhanwantri Nighantu". [5] It was also cultivated in the early 16th Century. [6] [7] It constituted 15% of revenue of British Raj from Colonial India. [8] The legalized cultivation and management of produce under strict government control continued in India even post independence.
Opium poppy (Papaver somniferous) plant is the source of opium gum which contains psychoactive alkaloids. Some of these alkaloids include Morphine, Codeine and Thebaine. Morphine is one of the most widely used analgesic in the world and is the precursor to Heroin, also known as diacetylmorphine. In case of extreme and excruciating pain such as that of terminally ill cancer patients, nothing alleviates the suffering except morphine. Codeine is commonly used in manufacture of cough syrups.
The NDPS act empowers the Central Government to permit and regulate cultivation of opium poppy for medical and scientific purposes. The Government of India notifies the tracts where opium cultivation can be licensed as well as the General Conditions for issuance of license every year. These notifications are commonly referred to as Opium Policies. Opium cultivation is permitted in the notified tracts in the states of Madhya Pradesh, Rajasthan and Uttar Pradesh The General Conditions, among others, include a Minimum Qualifying Yield (MQY) to be tendered by the cultivators of each of these three states, to be eligible for license in the succeeding year.
Presently, the Central Bureau of Narcotics (CBN), is responsible for overall supervision of cultivation as per provisions of the Narcotic Drugs and Psychotropic Substances Act, 1985. The produce from licensed cultivators are procured solely by government fixing strict norms on quantity and quality. The produce is then supplied by government to Government Opium and Alkaloid Factories (GOAF).
Each year the Central Government notifies the selected tracts where such cultivation will be permitted, and the general conditions for eligibility of the licence. The essential condition for issue of licence is, fulfillment of minimum qualifying yield (MQY) criterion, specified in number of kilograms per hectare. Cultivators who have tendered at least this quantity in the previous year are eligible for licence. The licence among other conditions, specifies the maximum area in which the opium crop can be sown.
If farmer realizes that the yield will be less than MQY then they have only an option of destroying the entire crop with government permission. If a farmer produces less than MQY then they may face legal action and will lose their license. [9]
The Central Bureau of Narcotics (CBN), Gwalior (Madhya Pradesh) under the Narcotics Commissioner issues licenses to the farmers to cultivate opium poppy. Some places where opium is grown are Pratapgarh in Rajasthan; Mandsaur, Ratlam, Neemuch in Madhya Pradesh; and Barabanki, Bareilly, Lucknow & Faizabad in Uttar Pradesh. For the crop year 2008-09, total number of licences issued was 44821, while MQY was fixed at 56 kg/ha for Rajasthan, Madhya Pradesh and 49 kg/ha for Uttar Pradesh. [10] Officers of Central Bureau of Narcotics measure each field and exercise controls to ensure that no excess cultivation takes place.
The crop year starts from November and ends on March every year. The extraction of opium takes place during the months of February and March. Farmers still use the traditional method where they lance each poppy capsule manually with a special blade like tool, a process known as lancing. The lancing is done in late afternoon or evenings. The opium latex which oozes out and congeals in the night is scraped and collected manually the next morning. Each poppy capsule is given three to four lancings.
All such opium collected is required to be necessarily tendered to the government, at specially set up opium collection centres, in early April. Opium is checked for quality and consistency and weighed at the centres. Prices are paid which are fixed by the Government in slab rates, depending on the quality and quantity of opium tendered. 90% of payment is made to the cultivators, directly in their bank account through e-payment method. Final payment is made after laboratory testing at opium factory after confirming that no adulterants have been found. [11] All the opium procured is sent to Government Opium and Alkaloid Factories situated at Neemuch and Ghazipur. Opium is dried and processed at these factories for export and is also used for extraction of various alkaloid products like Codeine phosphate, Thebaine, Morphine sulphate, Noscapine that are sold for pharmaceutical operations. But manufacturing of drugs such as Crude cocaine, ecgonine and diacetylmorphine (commonly known as heroin) and their salts are illegal and completely prohibited. [12] [13]
The state of West Bengal was trying to obtain permission to cultivate poppy since poppy seeds (khus khus) is an integral part of Bengali cuisine and hence has a huge domestic demand. [14]
There are rampant diversion and illegal production of opium found in India and India is regarded as third largest illicit opium producer in the world. [15] The diverted opium finds its way into North West Indian states like Punjab, where it forms an integral component in illegal drug trafficking. [16] There are ban on sale and trade of poppy husk (doda chura) a leftover from fields that was widely used in informal drug market in states like Rajasthan from 2015. [17] The wide difference between the prices in the illegal market (Rs. 60,000 - 120,000/- per kg) and government rates (Rs. 1800/- per kg) is one factor that prompts diversion and rampant corruption in enforcement. [18] There are strict laws against diversion in India. If caught then a farmer will lose their license to cultivate poppy and will be booked under Narcotic Drugs and Psychotropic Substances Act.
Opium addicts registered with the State Governments are supplied prescription opium by the Governments as part of deaddiction. The Government Opium and Alkaloid Works at Ghazipur and Neemuch sell opium to the State Governments who, in turn, supply it to the addicts. [19]
There are also instances of reduction in crop due to theft, attacks from animals, weather events like hailstorms, drought and attack of Parrots which are accused as diversion often. [20]
Morphine, formerly also called morphia, is an opiate that is found naturally in opium, a dark brown resin produced by drying the latex of opium poppies. It is mainly used as an analgesic. There are numerous methods used to administer morphine: oral; sublingual; via inhalation; injection into a muscle, injection under the skin, or injection into the spinal cord area; transdermal; or via rectal suppository. It acts directly on the central nervous system (CNS) to induce analgesia and alter perception and emotional response to pain. Physical and psychological dependence and tolerance may develop with repeated administration. It can be taken for both acute pain and chronic pain and is frequently used for pain from myocardial infarction, kidney stones, and during labor. Its maximum effect is reached after about 20 minutes when administered intravenously and 60 minutes when administered by mouth, while the duration of its effect is 3–7 hours. Long-acting formulations of morphine are available as MS-Contin, Kadian, and other brand names as well as generically.
Opium is dried latex obtained from the seed capsules of the opium poppy Papaver somniferum. Approximately 12 percent of opium is made up of the analgesic alkaloid morphine, which is processed chemically to produce heroin and other synthetic opioids for medicinal use and for the illegal drug trade. The latex also contains the closely related opiates codeine and thebaine, and non-analgesic alkaloids such as papaverine and noscapine. The traditional, labor-intensive method of obtaining the latex is to scratch ("score") the immature seed pods (fruits) by hand; the latex leaks out and dries to a sticky yellowish residue that is later scraped off and dehydrated.
Thebaine (paramorphine), also known as codeine methyl enol ether, is an opiate alkaloid, its name coming from the Greek Θῆβαι, Thēbai (Thebes), an ancient city in Upper Egypt. A minor constituent of opium, thebaine is chemically similar to both morphine and codeine, but has stimulatory rather than depressant effects. At high doses, it causes convulsions similar to strychnine poisoning. The synthetic enantiomer (+)-thebaine does show analgesic effects apparently mediated through opioid receptors, unlike the inactive natural enantiomer (−)-thebaine. While thebaine is not used therapeutically, it is the main alkaloid extracted from Papaver bracteatum and can be converted industrially into a variety of compounds, including hydrocodone, hydromorphone, oxycodone, oxymorphone, nalbuphine, naloxone, naltrexone, buprenorphine, butorphanol and etorphine.
The term narcotic originally referred medically to any psychoactive compound with numbing or paralyzing properties. In the United States, it has since become associated with opiates and opioids, commonly morphine and heroin, as well as derivatives of many of the compounds found within raw opium latex. The primary three are morphine, codeine, and thebaine.
A poppy is a flowering plant in the subfamily Papaveroideae of the family Papaveraceae. Poppies are herbaceous plants, often grown for their colourful flowers. One species of poppy, Papaver somniferum, is the source of the narcotic drug mixture opium, which contains powerful medicinal alkaloids such as morphine and has been used since ancient times as an analgesic and narcotic medicinal and recreational drug. It also produces edible seeds. Following the trench warfare in the poppy fields of Flanders, Belgium, during World War I, poppies have become a symbol of remembrance of soldiers who have died during wartime, especially in the UK, Canada, Australia, New Zealand and other Commonwealth realms.
Papaver somniferum, commonly known as the opium poppy or breadseed poppy, is a species of flowering plant in the family Papaveraceae. It is the species of plant from which both opium and poppy seeds are derived and is also a valuable ornamental plant grown in gardens. Its native range was east of the Mediterranean Sea, but has since been obscured and vastly expanded by introduction and cultivation from ancient times to the present day, being naturalized across much of Europe and Asia.
Neemuch or Nimach is a city in the Malwa region. Neemuch crowns the north western part of Madhya Pradesh. It has been also referred to city of Nature and Peace. The town shares its northwestern border with the state of Rajasthan and is the administrative headquarters of Neemuch District. Formerly a large British cantonment of Gwalior princely state, in 1822 the town became the headquarters of the combined Rajputana–Malwa political agency and of the Malwa Agency in 1895. The British Cantonment was disbanded in 1932 after which it was maintained by a British Municipal Board.
Poppy tea is a herbal tea infusion brewed from poppy straw or seeds of several species of poppy. The species most commonly used for this purpose is Papaver somniferum, which produces opium as a natural defense against predators. In the live flower, opium is released when the surface of the bulb, called the seed pod, is pierced or scraped. For the purpose of the tea, dried pods are more commonly used than the pods of the live flower. The walls of the dried pods contain opiate alkaloids, primarily consisting of morphine.
Afghanistan has long had a history of opium poppy cultivation and harvest. As of 2021, Afghanistan's harvest produces more than 90% of illicit heroin globally, and more than 95% of the European supply. More land is used for opium in Afghanistan than is used for coca cultivation in Latin America. The country has been the world's leading illicit drug producer since 2001. In 2007, 93% of the non-pharmaceutical-grade opiates on the world market originated in Afghanistan. By 2019 Afghanistan still produced about 84% of the world market. This amounts to an export value of about US $4 billion, with a quarter being earned by opium farmers and the rest going to district officials, insurgents, warlords, and drug traffickers. In the seven years (1994–2000) prior to a Taliban opium ban, the Afghan farmers' share of gross income from opium was divided among 200,000 families.
Pantopon, also known as Opium Alkaloids Hydrochlorides, is a preparation of opiates made up of all of the alkaloids present in opium in their natural proportions as hydrochlorides salts. It can sometimes be tolerated by people who are allergic to morphine.
Codeine is an opiate and prodrug of morphine mainly used to treat pain, coughing, and diarrhea. It is also commonly used as a recreational drug. It is found naturally in the sap of the opium poppy, Papaver somniferum. It is typically used to treat mild to moderate degrees of pain. Greater benefit may occur when combined with paracetamol (acetaminophen) or a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin or ibuprofen. Evidence does not support its use for acute cough suppression in children. In Europe, it is not recommended as a cough medicine in those under 12 years of age. It is generally taken by mouth. It typically starts working after half an hour, with maximum effect at two hours. Its effects last for about four to six hours. Codeine exhibits abuse potential similar to other opioid medications, including a risk of habituation and overdose.
Opium licensing is a policy instrument used to counter illegal drug cultivation and production. It has been used in countries such as Turkey and India to curb illegal opium production. The main mechanism used under opium licensing is a shift from cultivation and/or production for the illegal market towards legal uses such as the production of essential medicines such as morphine and codeine.
Afghan morphine or "Poppy for Medicine" is an alternative development solution put forward to combat the poverty and public disenchantment caused by international counter-narcotics eradication policies in Afghanistan. Licensing opium poppy cultivation in order to locally manufacture and market Afghan morphine, according to this proposal, would create the economic conditions to empower poverty stricken rural Afghans and cut their ties with the illicit poppy trade.
The Government Opium and Alkaloid Factories (GOAF) is an Indian government-owned organisation. Its headquarter is located in New Delhi. The overall supervision of the organisation comes under the purview of Department of Revenue, Ministry of Finance. There are two factories under this organisation - Government Opium and Alkaloid Works, Ghazipur (U.P.) and Government Opium and Alkaloid Works, Neemuch (M.P.).
Poppy straw is derived from opium poppies that are harvested when fully mature and dried by mechanical means. Opium poppy straw is what remains after the seed pods have been harvested - that is, the dried stalks, stem and leaves of poppies grown for their seeds. The field-dried leaves, stalk, and seed pod are then used in commercial manufacture of morphine or other poppy-alkaloid derived drugs, by first processing the material, separating the seeds, and then making concentrate of poppy straw where no extraction using the traditional methods of latex extraction has been made. The straw was originally considered an agricultural by-product of the mechanised poppy seed harvest, which was primarily grown for its edible and oil-producing seed. This changed in 1927 when János Kabay developed a chemical process to extract morphine from the crushed capsule. Concentrated poppy straw, consisting mainly of the crushed capsule without the seeds, soon became a valuable source of morphine. Today, concentrate of poppy straw is a major source of many opiates and other alkaloids. It is the source of 90% of the world supply of legal morphine and in some countries it also is a source of illegal morphine, which could be processed into illegal heroin.
Calcium morphenate is a calcium salt of morphine which is produced by using calcium bases to raise the pH of an aqueous solution of opium alkaloids to around 9.0. This was a method used in pharmaceutical manufacturing to separate morphine from other alkaloids and inert materials from the opium solution. Variations on this route are still used in Afghanistan. When poppy straw concentrate or opium latex is dissolved in hot water and the calcium base is added, calcium morphenate is formed. Treatment with a weak acid such as ammonium chloride then causes morphine freebase to precipitate, leaving codeine and other alkaloids of the plant in solution.
Extractas Bioscience (before called Tasmanian Alkaloids) is the largest opium poppy processing company in the Australian state of Tasmania. Approximately forty percent of the world's legal opiate crop is grown in Tasmania. Tasmanian Alkaloids was a subsidiary of the United States pharmaceutical company Johnson & Johnson, but was formerly—as of 1980—a subsidiary of Abbott Laboratories.
The major drug laws of India are the Narcotic Drugs and Psychotropic Substances Act (1985) and the Prevention of Illicit Trafficking in Narcotic Drugs and Psychotropic Substances Act (1988).
MacFarlan Smith is a pharmaceutical manufacturing company based in Edinburgh, Scotland, founded in 1815. After its sale from Johnson Matthey in June 2022 to Altaris Capital Partners, Macfarlan Smith rebranded as Veranova. Veranova is a CDMO specialising in the development and manufacturing of specialist and complex active pharmaceutical ingredients, or APIs. It has facilities across Europe and North America.
Central Bureau of Narcotics is affiliated with India's Department of Revenue (IRS) and regulated by the country's Central Board of Indirect Taxes and Customs. The main function of CBN is to stop opium production and trade, and to issue licenses for production of legal synthetic drugs. The Central Bureau of Narcotics headquarters is located at Gwalior.