Licoflavone C

Last updated

Licoflavone C
Licoflavone-C structure.png
Identifiers
  • 5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)chromen-4-one
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C20H18O5
Molar mass 338.359 g·mol−1
3D model (JSmol)
  • CC(=CCC1=C2C(=C(C=C1O)O)C(=O)C=C(O2)C3=CC=C(C=C3)O)C
  • InChI=1S/C20H18O5/c1-11(2)3-8-14-15(22)9-16(23)19-17(24)10-18(25-20(14)19)12-4-6-13(21)7-5-12/h3-7,9-10,21-23H,8H2,1-2H3
  • Key:MEHHCBRCXIDGKZ-UHFFFAOYSA-N

Licoflavone C is a natural product isolated from numerous plant species including Glycyrrhiza inflata , Morus alba , and Artocarpus communis . It has antiiflammatory, antiviral and anti-cancer properties in vitro and is of interest in herbal medicine. [1] [2] [3] [4] [5] [6] [7] [8] [9]

See also

References

  1. ↑ Pistelli L, Bertoli A, Giachi I, Manunta A (November 1998). "Flavonoids from genista ephedroides". Journal of Natural Products. 61 (11): 1404–1406. Bibcode:1998JNAtP..61.1404P. doi:10.1021/np980112s. PMID   9834164.
  2. ↑ Han AR, Kang YJ, Windono T, Lee SK, Seo EK (April 2006). "Prenylated flavonoids from the heartwood of Artocarpus communis with inhibitory activity on lipopolysaccharide-induced nitric oxide production". Journal of Natural Products. 69 (4): 719–721. Bibcode:2006JNAtP..69..719H. doi:10.1021/np0600346. PMID   16643064.
  3. ↑ Wätjen W, Weber N, Lou YJ, Wang ZQ, Chovolou Y, Kampkötter A, et al. (January 2007). "Prenylation enhances cytotoxicity of apigenin and liquiritigenin in rat H4IIE hepatoma and C6 glioma cells". Food and Chemical Toxicology. 45 (1): 119–124. doi:10.1016/j.fct.2006.08.008. PMID   17045382.
  4. ↑ Pinto B, Bertoli A, Noccioli C, Garritano S, Reali D, Pistelli L (March 2008). "Estradiol-antagonistic activity of phenolic compounds from leguminous plants". Phytotherapy Research. 22 (3): 362–366. doi:10.1002/ptr.2327. PMID   18167044.
  5. ↑ Scarpato R, Paganucci L, Bertoli A, Fiore L, Pistelli L, Federico G (December 2008). "Licoflavone C attenuates the genotoxicity of cancer drugs in human peripheral lymphocytes". Phytotherapy Research. 22 (12): 1650–1654. doi:10.1002/ptr.2546. PMID   18979523.
  6. ↑ Li M, Wu X, Wang X, Shen T, Ren D (January 2018). "Two novel compounds from the root bark of Morus alba L". Natural Product Research. 32 (1): 36–42. doi:10.1080/14786419.2017.1327862. PMID   28521570.
  7. ↑ Zejli H, Metouekel A, Zouirech O, Maliki I, El Moussaoui A, Lfitat A, et al. (January 2024). "Phytochemical Analysis, Antioxidant, Analgesic, Anti-Inflammatory, Hemagglutinin and Hemolytic Activities of Chemically Characterized Extracts from Origanum grosii (L.) and Thymus pallidus (L.)". Plants. 13 (3): 385. Bibcode:2024Plnts..13..385Z. doi: 10.3390/plants13030385 . PMC   10857174 . PMID   38337918.
  8. ↑ Gao X, He XX, Zhu XR, Wu Y, Lu J, Chen XL, et al. (September 2025). "Identification of Licoflavone C as a cap-dependent endonuclease inhibitor against severe fever with thrombocytopenia syndrome virus". Acta Pharmacologica Sinica. 46 (9): 2482–2495. doi:10.1038/s41401-025-01533-7. PMC  12373745. PMID   40169781.
  9. ↑ do Nascimento JB, da Costa JG (2025). "Flavonoids: A Review of Antibacterial Activity Against Gram-Negative Bacteria". International Journal of Microbiology. 2025 9961121. doi: 10.1155/ijm/9961121 . PMC   12453933 . PMID   40988989.
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