| Ligneous conjunctivitis | |
|---|---|
| Other names | Conjunctivitis lignosa [1] |
| Specialty | Ophthalmology |
Ligneous conjunctivitis is a rare form of chronic conjunctivitis characterized by recurrent, fibrin-rich pseudomembranous lesions of wood-like consistency that develop mainly on the underside of the eyelid (tarsal conjunctiva). [2] It is generally a systemic disease which may involve the periodontal tissue, the upper and lower respiratory tract, kidneys, middle ear, and female genitalia. [3] It can be sight-threatening, [3] and death can occasionally occur from pulmonary involvement.[ citation needed ]
It has been speculated hola ligneous conjunctivitis may be a manifestation of IgG4-related disease (IgG4-RD) involving the conjunctiva. [4]
Histopathological findings from affected humans indicate that wound healing is impaired due to a deficiency in plasmin-mediated extracellular fibrinolysis. [2] Episodes may be triggered by minor trauma, eye surgery, or by systemic events such as infections or antifibrinolytic therapy. [3] Histology shows amorphous subepithelial deposits of eosinophilic material consisting predominantly of fibrin.[ clarification needed ]
Ligneous conjunctivitis may be managed by topical treatments of plasminogen, [2] topical and subconjunctival fresh frozen plasma, [2] and fibrinolytic therapy. [5]
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